Results 71 to 80 of about 194,703 (370)
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
eLife, 2016 Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown.
Gertrudis Perea +18 more
doaj +1 more source
Astrocyte-Enabled Advancements in Spiking Neural Networks for Large Language Modeling [PDF]
arXiv, 2023 Within the complex neuroarchitecture of the brain, astrocytes play crucial roles in development, structure, and metabolism. These cells regulate neural activity through tripartite synapses, directly impacting cognitive processes such as learning and memory. Despite the growing recognition of astrocytes' significance, traditional Spiking Neural Network (
arxiv
Graphene oxide upregulates the homeostatic functions of primary astrocytes and modulates astrocyte-to-neuron communication [PDF]
Nano Lett. 2018, 18, 9, 5827-5838, 2018 Graphene-based materials are the focus of intense research efforts to devise novel theranostic strategies for targeting the central nervous system. In this work, we have investigated the consequences of long-term exposure of primary rat astrocytes to pristine graphene (GR) and graphene oxide (GO) flakes.
arxiv +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Introducing Astrocytes on a Neuromorphic Processor: Synchronization, Local Plasticity and Edge of Chaos [PDF]
ACM Proceeding NICE '19 Proceedings of the 7th Annual
Neuro-inspired Computational Elements Workshop, 2019, 2019 While there is still a lot to learn about astrocytes and their neuromodulatory role in the spatial and temporal integration of neuronal activity, their introduction to neuromorphic hardware is timely, facilitating their computational exploration in basic science questions as well as their exploitation in real-world applications.
arxiv +1 more source
Astrocyte morphology: Diversity, plasticity, and role in neurological diseases
CNS Neuroscience & Therapeutics, 2019 Astrocytes are the most abundant glial cells in the central nervous system (CNS) and participate in synaptic, circuit, and behavioral functions.
Bin Zhou, Y. Zuo, Ruotian Jiang
semanticscholar +1 more source
Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System
Cells, 2020 Over the last decade knowledge of the role of astrocytes in central nervous system (CNS) neuroinflammatory diseases has changed dramatically. Rather than playing a merely passive role in response to damage it is clear that astrocytes actively maintain ...
E. Nutma +3 more
semanticscholar +1 more source
Ultrastructural view of astrocyte-astrocyte and astrocyte-synapse contacts within the hippocampus [PDF]
, 2020 SummaryAstrocytes branch out and make contact at their interfaces. However, the ultrastructural interactions of astrocytes and astrocytes with their surroundings, including the spatial-location selectivity of astrocyte-synapse contacts, remain unknown. Here, the branching architecture of three neighboring astrocytes, their contact interfaces, and their
Emily P. Arzola +14 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source