Results 261 to 270 of about 1,396,802 (284)

IP3R1-dependent astrocyte calcium signaling in chronic itch

Neuroscience Research, 2023
Astrocytes, the most abundant type of glial cell, are electrically non-excitable cells that use intracellular calcium (Ca2+) for functional regulation. Changes in intracellular Ca2+ concentration play important roles in the central nervous system (CNS), as they are involved in the release of gliotransmitters and the control of extracellular ion ...
Miho, Shiratori-Hayashi, Makoto, Tsuda
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Glucocorticoids?potent modulators of astrocytic calcium signaling

Glia, 1999
Glucocorticoids are the first line of choice in the treatment of cerebral edema associated with brain tumors. High-dose glucocorticoids reduce the extent of edema within hours, often relieving critical increases in intracranial pressure, but the mechanisms by which glucocorticoids modulate brain water content are not well-understood.
M, Simard, W T, Couldwell, W, Zhang, H, Song, S, Liu, M L, Cotrina, S, Goldman, M, Nedergaard   +7 more
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Components of Astrocytic Intercellular Calcium Signaling

Molecular Neurobiology, 2000
It has become evident that astrocytes play major roles in central nervous system (CNS) function. Because they are endowed with ion channels, transport pathways, and enzymatic intermediates optimized for ionic uptake, degradation of metabolic products, and inactivation of numerous substances, they are able to sense and correct for changes in neural ...
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Calcium ion signaling in astrocytes

2008
Ca 2+ signaling has been recognized as one of the major second messenger steps in most cell types, including astrocytes, the major macroglial cell type in vertebrate nervous systems. Astrocytes are by no means a homogeneous group of glial cells, but comprise a number of different cell types (see Chap. 1).
Joachim W. Deitmer, Karthika Singaravelu, Christian Lohr   +2 more
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Meningeal cells can communicate with astrocytes by calcium signaling

Annals of Neurology, 2000
Mechanical stimulation of adult human and rat pia-arachnoid cell cultures (loaded with calcium indicator dye) produced an increase in calcium in the stimulated cell. This change then propagated rapidly among neighboring cells, producing a calcium wave with a maximum distance of propagation and velocity resembling calcium waves in astrocytes.
B, Grafstein, S, Liu, M L, Cotrina, S A, Goldman, M, Nedergaard   +4 more
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Calcium Channel Signaling in Astrocytes

1993
It has been known for more than a century that the brain contains not only neurons but also non-neuronal cells. Most of the non-neuronal cells belong to the two glial cell types, oligodendrocytes and astrocytes. In many species, including man, they vastly outnumber neurons (1).
Leif Hertz, William E. Code
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Calcium signals in astrocytes of the fly brain promote sleep

Cell Calcium, 2021
Astrocytes are morphologically and functionally linked to neuronal synapses, and can regulate the activity of neural circuits, brain function, and behavior. However, the molecular mechanisms by which astrocytes regulate fundamental biological processes such as sleep are not completely understood.
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Intercellular calcium signaling and gap junctional communication in astrocytes

Glia, 1998
Two main characteristics of astrocytes are their elaborated intracellular calcium signaling and their high degree of intercellular communication mediated by gap junctional channels. In these cells a number of studies have contributed to demonstrate that the combination of these two properties provides a basis for a long-range signaling system within ...
Giaume, C., Venance, L.
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Characteristics of thrombin-induced calcium signals in rat astrocytes

Glia, 1997
The protease thrombin seems to play a central role in events following neural injury, whereby the enzyme can act, in concert with other molecules as a hormone or as a growth factor. In cells derived from the nervous system, thrombin induces changes in morphology and proliferation. The signalling mechanisms involved in these thrombin-activated processes
J J, Ubl, G, Reiser
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Astrocyte-endothelial cell calcium signals conveyed by two signalling pathways

European Journal of Neuroscience, 2001
Astrocytes and endothelial cells are in close contact with each other at the blood-brain barrier, where important molecular transports take place. Despite these key morphological and functional properties, little is known regarding the dynamic signalling processes that occur between these two cell types.
Braet, K., Paemeleire, K., D'Herde, K., Sanderson, M. J., Leybaert, L.   +4 more
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