Gliotransmission Modulates Baseline Mechanical Nociception [PDF]
Molecular Pain, 2011 Pain is a physiological and adaptive process which occurs to protect organisms from tissue damage and extended injury. Pain sensation beyond injury, however, is a pathological process which is poorly understood.
Philip Haydon
exaly +10 more sources
Astrocyte Gliotransmission in the Regulation of Systemic Metabolism [PDF]
Metabolites, 2021 Normal brain function highly relies on the appropriate functioning of astrocytes. These glial cells are strategically situated between blood vessels and neurons, provide significant substrate support to neuronal demand, and are sensitive to neuronal ...
Cristina Garcia-Caceres, Cahuê Murat
exaly +6 more sources
Gliotransmission by Prostaglandin E2: A Prerequisite for GnRH Neuronal Function? [PDF]
Frontiers in Endocrinology, 2011 Over the past four decades it has become clear that prostaglandin E2 (PGE2), a phospholipid-derived signaling molecule, plays a fundamental role in modulating the GnRH neuroendocrine system and in shaping the hypothalamus.
Vincent Prevot +2 more
exaly +5 more sources
Deletion of Astrocytic TNFR1 Attenuates Hyperexcitability and Initiation of Epileptogenesis. [PDF]
GliaInducible, astrocyte‐specific deletion of TNFR1 reduces basal EEG spectral power. Loss of astrocytic TNFR1 attenuates acute seizure activity in two distinct experimental models of epilepsy. Deletion of TNFR1 in astrocytes limits epilepsy development and hippocampal pathology in a mouse model of temporal lobe epilepsy with hippocampal sclerosis ...
Henning L +6 more
europepmc +2 more sources
Journal of Nanobiotechnology, 2022 Background Astrocyte is a key regulator of neuronal activity and excitatory/inhibitory balance via gliotransmission. Recently, gliotransmission has been identified as a novel target for neurological diseases.
Hae-Won Kim +2 more
exaly +2 more sources
Female Mice Show Stronger Time-of-Day Modulation of Astrocytic Ca<sup>2+</sup> Activity in the Sleep-Regulatory Ventrolateral Preoptic Nucleus. [PDF]
GliaVLPO astrocytes exhibit sex‐specific Ca2+ dynamics across the nycthemeral cycle. Males show faster Ca2+ kinetics, while females display increased amplitude, frequency, and network coupling at Zeitgeber Time (ZT)‐14. Sex is a key variable in astrocyte‐based sleep regulation mechanisms.
Bellier FC +5 more
europepmc +2 more sources
Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine [PDF]
Frontiers in Cellular Neuroscience, 2023 Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through the release of gliotransmitters, a process mediated by intracellular Ca2+ level changes and SNARE-dependent mechanisms.
Daniela Sofia Abreu +11 more
doaj +2 more sources
Astrocyte alterations in α-synucleinopathies [PDF]
Frontiers in Cellular NeuroscienceDespite long being considered to be passive and supportive cells, in the last decades astrocytes have arisen as key regulators of neuronal excitability, synaptic transmission and plasticity.
Manuela Rodríguez-Castañeda +9 more
doaj +2 more sources
Constellations of Thought: Astrocytic Contributions to Cognition Across Rodent Models of Brain Dysfunction [PDF]
BiomoleculesAstrocytes are now recognized as active and essential participants in neural circuit function, extending far beyond their traditional roles as passive support cells.
Konstantin Andrianov +1 more
doaj +2 more sources
ASTROGLIA: Molecular Mechanisms, Functional Roles, and Neurophysiological Implications in the Central Nervous System [PDF]
LifeAstrocytes, the principal components of astroglia, play essential roles in maintaining neuronal and synaptic homeostasis in the central nervous system.
Andrea Ortega +5 more
doaj +2 more sources