Structural Heterogeneity of the GABAergic Tripartite Synapse [PDF]
Cells, 2022 The concept of the tripartite synapse describes the close interaction of pre- and postsynaptic elements and the surrounding astrocyte processes. For glutamatergic synapses, it is established that the presence of astrocytic processes and their structural ...
Cindy Brunskine +2 more
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A tripartite synapse model in Drosophila. [PDF]
PLoS ONE, 2011 Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only ...
Rie Danjo +2 more
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Impact of a pyridazine derivative on tripartite synapse ultrastructure in hippocampus: a three-dimensional analysis [PDF]
Frontiers in Cellular Neuroscience, 2023 IntroductionWe previously discovered a pyridazine derivative compound series that can improve cognitive functions in mouse models of Alzheimer’s disease.
Chien-Liang Glenn Lin, Joshua B Foster
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Ion dynamics at the energy-deprived tripartite synapse. [PDF]
PLoS Computational Biology, 2021 The anatomical and functional organization of neurons and astrocytes at 'tripartite synapses' is essential for reliable neurotransmission, which critically depends on ATP.
Manu Kalia +4 more
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Microglia at the Tripartite Synapse during Postnatal Development: Implications for Autism Spectrum Disorders and Schizophrenia [PDF]
Cells, 2023 Synapses are the fundamental structures of neural circuits that control brain functions and behavioral and cognitive processes. Synapses undergo formation, maturation, and elimination mainly during postnatal development via a complex interplay with ...
Davide Ragozzino +2 more
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The Nanoworld of the Tripartite Synapse: Insights from Super-Resolution Microscopy [PDF]
Frontiers in Cellular Neuroscience, 2017 Synaptic connections between individual nerve cells are fundamental to the process of information transfer and storage in the brain. Over the past decades a third key partner of the synaptic machinery has been unveiled: ultrathin processes of ...
Dmitri A Rusakov, Janosch Heller
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Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS [PDF]
Mathematics, 2021 Astrocyte cells form the largest cell population in the brain and can influence neuron behavior. These cells provide appropriate feedback control in regulating neuronal activities in the Central Nervous System (CNS).
E Nazemi - Nazemi E +2 more
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Three's Company: Neuroimmune activation, sex, and memory at the tripartite synapse [PDF]
Brain, Behavior, & Immunity - Health, 2021 The neuroimmune system is required for normal cognitive functions such as learning and memory in addition to its critical role in detecting and responding to invading pathogens and injury.
Caitlin K. Posillico
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Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease [PDF]
Frontiers in Cellular Neuroscience, 2018 Astrocytes, which are five-fold more numerous than neurons in the central nervous system (CNS), are traditionally viewed to provide simple structural and nutritional supports for neurons and to participate in the composition of the blood brain barrier ...
Cai-Yun Liu +5 more
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Astrocyte-mediated higher-order control of synaptic plasticity [PDF]
Communications BiologyThe dynamics of higher-order topological signals are increasingly recognized as a key aspect of the activity of complex systems. A paradigmatic example are synaptic dynamics: synaptic efficacy changes over time driven by different mechanisms.
Gustavo Menesse +2 more
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