Results 21 to 30 of about 85,493 (199)
Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy [PDF]
Experimental Neurology, 2020 Cheryl Clarkson +2 more
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Neuron-astrocyte omnidirectional signaling in neurological health and disease
Frontiers in Molecular Neuroscience, 2023 Astrocytes are an abundantly distributed population of glial cells in the central nervous system (CNS) that perform myriad functions in the normal and injured/diseased brain.
Dhruba Pathak, Krishnan Sriram
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The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
Frontiers in Cellular Neuroscience, 2022 Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people worldwide. One pathological feature of progressing AD is the loss of synapses. This is the strongest correlate of cognitive decline.
Lianne A. Hulshof +4 more
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Frontiers in Cellular Neuroscience, 2023 IntroductionAstrocyte-synapse bi-directional communication is required for neuronal development and synaptic plasticity. Astrocytes structurally interact with synapses using their distal processes also known as leaflets or perisynaptic astrocytic ...
Mandy S. J. Kater +4 more
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Purinergic Tuning of the Tripartite Neuromuscular Synapse
Molecular Neurobiology, 2023 AbstractThe vertebrate neuromuscular junction (NMJ) is a specialised chemical synapse involved in the transmission of bioelectric signals between a motor neuron and a skeletal muscle fiber, leading to muscle contraction. Typically, the NMJ is a tripartite synapse comprising (a) a presynaptic region represented by the motor nerve ending, (b) a ...
Carlos Sousa-Soares +2 more
openaire +2 more sources
Hippocampal astrocytes modulate anxiety-like behavior
Nature Communications, 2022 Astrocytes affect animal behaviors by regulating the tripartite synapse. Here, the authors show that hippocampal astrocytes modulate mouse anxiety-like behavior by regulating synaptic homeostasis of dentate gyrus granule cells via ATP release.
Woo-Hyun Cho +6 more
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From Synapses to Circuits, Astrocytes Regulate Behavior
Frontiers in Neural Circuits, 2022 Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior. Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes influence synapse formation, function, and plasticity.
Krissy A. Lyon, Nicola J. Allen
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Urokinase-type plasminogen activator (uPA) protects the tripartite synapse in the ischemic brain via ezrin-mediated formation of peripheral astrocytic processes. [PDF]
J Cereb Blood Flow Metab, 2019 Cerebral ischemia has a harmful effect on the synapse associated with neurological impairment. The “tripartite synapse” is assembled by the pre- and postsynaptic terminals, embraced by astrocytic elongations known as peripheral astrocytic processes ...
Diaz A +4 more
europepmc +2 more sources
Calcium signaling in astrocytes and gliotransmitter release
Frontiers in Synaptic Neuroscience, 2023 Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support.
Julianna Goenaga +3 more
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Frontiers in Synaptic Neuroscience, 2023 Astrocytes are known to actively participate in synaptic communication by forming structures called tripartite synapses. These synapses consist of presynaptic axon terminals, postsynaptic dendritic spines, and astrocytic processes where astrocytes ...
Jooyoung Kim, Bong-Kiun Kaang
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