Results 31 to 40 of about 1,835 (174)
Revealing the contribution of astrocytes to glutamatergic neuronal transmission
Frontiers in Cellular Neuroscience, 2023 Research on glutamatergic neurotransmission has focused mainly on the function of presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to ensure successful neurotransmission.
Ares Orlando Cuellar-Santoyo +8 more
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Gliotransmission: Exocytotic release from astrocytes [PDF]
Brain Research Reviews, 2010 Gliotransmitters are chemicals released from glial cells fulfilling a following set of criteria: (i) they are synthesized by and/or stored in glia; (ii) their regulated release is triggered by physiological and/or pathological stimuli; (iii) they activate rapid (milliseconds to seconds) responses in neighboring cells; and (iv) they play a role in ...
Vladimir, Parpura, Robert, Zorec
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Biomolecules, 2021 Until recently, astrocytes were thought to be a part of a simple “brain glue” providing only a supporting role for neurons. However, the discoveries of the last two decades have proven astrocytes to be dynamic partners participating in brain metabolism ...
Aleksandra Mielnicka, Piotr Michaluk
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Gliotransmission and Brain Glucose Sensing [PDF]
Diabetes, 2013 Hypothalamic glucose sensing is involved in the control of feeding behavior and peripheral glucose homeostasis, and glial cells are suggested to play an important role in this process. Diazepam-binding inhibitor (DBI) and its processing product the octadecaneuropeptide (ODN), collectively named endozepines, are secreted by astroglia, and ODN is a ...
Lanfray, Damien +15 more
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Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
Nature, 2023 AbstractMultimodal astrocyte–neuron communications govern brain circuitry assembly and function1. For example, through rapid glutamate release, astrocytes can control excitability, plasticity and synchronous activity2,3 of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions4–7.
Roberta de Ceglia +18 more
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The Paradox of Astroglial Ca2 + Signals at the Interface of Excitation and Inhibition
Frontiers in Cellular Neuroscience, 2020 Astroglial networks constitute a non-neuronal communication system in the brain and are acknowledged modulators of synaptic plasticity. A sophisticated set of transmitter receptors in combination with distinct secretion mechanisms enables astrocytes to ...
Laura C. Caudal +3 more
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Astrocytes as a target for therapeutic strategies in epilepsy: current insights
Frontiers in Molecular Neuroscience, 2023 Astrocytes are specialized non-neuronal glial cells of the central nervous system, contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes play a key roles in epileptogenesis and seizure generation.
Nihan Çarçak +4 more
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Connexin-Mediated Functional and Metabolic Coupling Between Astrocytes and Neurons
Frontiers in Molecular Neuroscience, 2018 The central nervous system (CNS) requires sophisticated regulation of neuronal activity. This modulation is partly accomplished by non-neuronal cells, characterized by the presence of transmembrane gap junctions (GJs) and hemichannels (HCs).
Lady C. Mayorquin +3 more
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Gliotransmission and adenosinergic modulation : insights from mammalian spinal motor networks [PDF]
, 2017 D Acton was supported by funds from a Wellcome Trust Institutional Strategic Support Fund grant. GBM received support from Biotechnology and Biological Science Research Grant BB/M021793/1.Astrocytes are proposed to converse with neurons at tripartite ...
David Acton +3 more
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Astrocytes Modulate Somatostatin Interneuron Signaling in the Visual Cortex
Cells, 2022 At glutamatergic synapses, astrocytes respond to the neurotransmitter glutamate with intracellular Ca2+ elevations and the release of gliotransmitters that modulate synaptic transmission.
Vanessa Jorge Henriques +3 more
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