Results 21 to 30 of about 1,835 (174)

Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue [PDF]

open access: yesCerebral Cortex, 2012
Brain function is recognized to rely on neuronal activity and signaling processes between neurons, whereas astrocytes are generally considered to play supportive roles for proper neuronal function. However, accumulating evidence indicates that astrocytes
Perea, Gertrudis   +8 more
core   +4 more sources

Plasmalemmal Na/Ca Exchanger Modulates Ca-Dependent Exocytotic Release of Glutamate from Rat Cortical Astrocytes

open access: yesASN Neuro, 2012
Astroglial excitability operates through increases in Ca 2+ cyt (cytosolic Ca 2+ ), which can lead to glutamatergic gliotransmission. In parallel fluctuations in astrocytic Na + cyt (cytosolic Na + ) control metabolic neuronal-glial signalling, most ...
Reno C Reyes   +2 more
doaj   +2 more sources

Calcium signaling and gliotransmission in normal versus reactive astrocytes [PDF]

open access: yesFrontiers in Pharmacology, 2012
A prominent area of neuroscience research over the past 20 years has been the acute modulation of neuronal synaptic activity by Ca2+-dependent release of the transmitters ATP, D-serine, and glutamate (called gliotransmitters) by astrocytes.
Cendra eAgulhon   +5 more
doaj   +3 more sources

Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission

open access: yes, 2015
Astrocytes can be defined as glia inhabiting the nervous system with the main function in the maintenance of nervous tissue homeostasis. Classified into several types according to their morphological appearance, many of astrocytes form a reticular ...
Parpura, V   +1 more
core   +10 more sources

Astrocyte ryanodine receptors facilitate gliotransmission and astroglial modulation of synaptic plasticity

open access: yesFrontiers in Cellular Neuroscience
Intracellular Ca2+-signaling in astrocytes is instrumental for their brain “housekeeping” role and astroglial control of synaptic plasticity. An important source for elevating the cytosolic Ca2+ level in astrocytes is a release from endoplasmic reticulum
Yuriy Pankratov, Ulyana Lalo
exaly   +3 more sources

Calcium signaling in astrocytes and gliotransmitter release

open access: yesFrontiers in Synaptic Neuroscience, 2023
Glia are as numerous in the brain as neurons and widely known to serve supportive roles such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and metabolic support.
Julianna Goenaga   +3 more
doaj   +1 more source

Swelling Gliotransmission by SWELL1 Channels [PDF]

open access: yesNeuron, 2019
Astrocytes release glutamate, which can modulate nearby synapses, but how this release is accomplished remains debated. In this issue of Neuron, Yang et al. (2019) show that the volume-regulated anion channel Swell1 in astrocytes mediates the release of glutamate and impacts synaptic transmission, learning and memory, and neurotoxicity.
Paulo, Kofuji, Alfonso, Araque
openaire   +2 more sources

Calcium Signals in Astrocyte Microdomains, a Decade of Great Advances

open access: yesFrontiers in Cellular Neuroscience, 2021
The glial cells astrocytes have long been recognized as important neuron-supporting elements in brain development, homeostasis, and metabolism. After the discovery that the reciprocal communication between astrocytes and neurons is a fundamental ...
Annamaria Lia   +12 more
doaj   +1 more source

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