Results 241 to 250 of about 1,396,802 (284)

Brassinin Inhibits Cell Survival and Autophagy via Modulation of ROS Production and the AMPKα‐beclin1 Signaling Pathway in Gliomas

Phytotherapy Research, EarlyView.
Brassinin, a phytoalexin derived primarily from Chinese cabbage, exhibits potent anticancer activity against glioblastoma (GBM). Mechanistically, brassinin treatment elevates intracellular ROS levels in GBM cells, triggering two parallel outcomes: (i) direct induction of apoptosis, and (ii) suppression of cytoprotective autophagy through downregulation
Sunil Rauniyar, Yuhui Wang, Qiaoshan Zhang, Shicheng Zhang, Jiale Yin, Tong Zhang, Shangfeng Gao, Rutong Yu   +7 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Astrocyte-derived HMGB1 compromises the integrity of the blood-brain barrier through the CaM/CaMKII/AQP4 pathway and the protective function of trifluoperazine. [PDF]

Front Immunol
Zou SS, Chen LL, Cui M.
europepmc   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Astrocyte-Neuron Crosstalk in Hypertension: Mechanisms and Therapeutic Significance. [PDF]

Rev Cardiovasc Med
Zhao M, Jia H, Li N.
europepmc   +1 more source

Conservation of Neuron-Astrocyte Correlated Activity in Developing Sensory Pathways. [PDF]

Glia
Kellner V, Parker P, Heo D, Mi X, Coen M, Yu G, Saher G, Goff LA, Bergles DE.   +8 more
europepmc   +1 more source

Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis. [PDF]

J Cell Biol
Yang L, Björklund M, Yi C, Chen S, Hong Z.   +4 more
europepmc   +1 more source

Spinal Cord Stimulation Alleviates Neuropathic Pain Involves Regulation of the Ca²⁺/CaN/NFAT4 Pathway in Spinal Dorsal Horn Astrocytes. [PDF]

Cell Mol Neurobiol
Li X, Wu Z, Wang R, Bai J.
europepmc   +1 more source

Molecular and Cellular Mechanisms Linking Mood Disorders, HPA Axis Dysregulation, and Neurocognitive Inflammation to Perioperative Neurocognitive Disorders. [PDF]

Biomolecules
Sato A, Chang N, Knezevic NN, Paisansathan C.   +3 more
europepmc   +1 more source