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Components of Astrocytic Intercellular Calcium Signaling
Molecular Neurobiology, 2000It has become evident that astrocytes play major roles in central nervous system (CNS) function. Because they are endowed with ion channels, transport pathways, and enzymatic intermediates optimized for ionic uptake, degradation of metabolic products, and inactivation of numerous substances, they are able to sense and correct for changes in neural ...
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Calcium ion signaling in astrocytes
2008Ca 2+ signaling has been recognized as one of the major second messenger steps in most cell types, including astrocytes, the major macroglial cell type in vertebrate nervous systems. Astrocytes are by no means a homogeneous group of glial cells, but comprise a number of different cell types (see Chap. 1).
Joachim W. Deitmer +2 more
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Meningeal cells can communicate with astrocytes by calcium signaling
Annals of Neurology, 2000Mechanical stimulation of adult human and rat pia-arachnoid cell cultures (loaded with calcium indicator dye) produced an increase in calcium in the stimulated cell. This change then propagated rapidly among neighboring cells, producing a calcium wave with a maximum distance of propagation and velocity resembling calcium waves in astrocytes.
B, Grafstein +4 more
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Calcium Channel Signaling in Astrocytes
1993It has been known for more than a century that the brain contains not only neurons but also non-neuronal cells. Most of the non-neuronal cells belong to the two glial cell types, oligodendrocytes and astrocytes. In many species, including man, they vastly outnumber neurons (1).
Leif Hertz, William E. Code
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Characteristics of thrombin-induced calcium signals in rat astrocytes
Glia, 1997The protease thrombin seems to play a central role in events following neural injury, whereby the enzyme can act, in concert with other molecules as a hormone or as a growth factor. In cells derived from the nervous system, thrombin induces changes in morphology and proliferation. The signalling mechanisms involved in these thrombin-activated processes
J J, Ubl, G, Reiser
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Astrocyte-endothelial cell calcium signals conveyed by two signalling pathways
European Journal of Neuroscience, 2001Astrocytes and endothelial cells are in close contact with each other at the blood-brain barrier, where important molecular transports take place. Despite these key morphological and functional properties, little is known regarding the dynamic signalling processes that occur between these two cell types.
Braet, K. +4 more
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Aspects of Astrocytic Calcium Signaling
2006Astrocytes constitute the largest glial cell population within the mammalian brain. A major part of astrocytic intra- and intercellular signaling occurs through dynamic changes in the cytosolic Ca2+ concentration. For a better insight into astrocytic reactions to changes in their environment, the specifics of this cellular Ca2+ code need to be ...
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The Effect of Midazolam on Calcium Signaling in Astrocytes
Annals of the New York Academy of Sciences, 1991W E, Code, H S, White, L, Hertz
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