Results 121 to 130 of about 123,114 (319)
Advanced Materials Interfaces, EarlyView.Brain movement significantly impacts the biocompatibility of neural probes due to continuous strain on neural tissue. This study examines strain profiles across various brain models and movement types, challenging the 5% damage threshold at the electrode–tissue interface.
Ali Sharbatian +3 more
wiley +1 more source
Computational models of astrocyte function at glutamatergic synapses [PDF]
New Technologies for Glutamate Interactions: Neurons and Glia,
edited by Maria Kukley, 2024, Springer ProtocolsAt tripartite synapses, astrocytes are in close contact with neurons and contribute to various functions, from synaptic transmission, maintenance of ion homeostasis and glutamate uptake to metabolism. However, disentangling the precise contribution of astrocytes to those phenomena and the underlying biochemical mechanisms is remarkably challenging ...
arxiv +1 more source
Memory in astrocytes: a hypothesis [PDF]
Theoretical Biology and Medical Modelling, 2006 AbstractBackgroundRecent work has indicated an increasingly complex role for astrocytes in the central nervous system. Astrocytes are now known to exchange information with neurons at synaptic junctions and to alter the information processing capabilities of the neurons.
openaire +3 more sources
The Role of Silicon Technology in Organ‐On‐Chip: Current Status and Future Perspective
Advanced Materials Technologies, EarlyView.This review explores the potential of silicon micro‐nanofabrication technologies in advancing organ‐on‐chip systems. The integration of actuation and sensing modalities, highlight emerging technologies is discussed for combining silicon‐based and polymer‐based components, and emphasize the need for robust, high‐throughput, and customizable organ‐on ...
Frøydis Sved Skottvoll +2 more
wiley +1 more source
The Multi-Scale Impact of the Alzheimer's Disease in the Topology Diversity of Astrocytes Molecular Communications Nanonetworks [PDF]
arXiv, 2018 The Internet of Bio-Nano-Things is a new paradigm that can bring novel remotely controlled actuation and sensing techniques inside the human body. Towards precise bionano sensing techniques in the brain, we investigate the challenges of modelling spatial distribution of astrocyte networks in developing a mathematical framework that lay the groundwork ...
arxiv
Biological and Mechanical Limitations for Chronic Fast‐Scan Cyclic Voltammetry Sensor Design
Advanced Materials Technologies, EarlyView.Real‐time detection of neurochemicals has demonstrated value in the field of neuroscience. However, current methods have limitations for use in the chronic setting, which is often the ideal environment for research. This article discusses these limitations, as well as technologies that have been developed to overcome them, and provides recommendations ...
Mason L. Perillo +6 more
wiley +1 more source
Questions and (some) answers on reactive astrocytes
Glia, 2019 Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes react to virtually all types of pathological alterations in brain homeostasis by significant morphological and molecular changes.
C. Escartin +2 more
semanticscholar +1 more source
Pathological phenotypes of astrocytes in Alzheimer’s disease
Experimental and Molecular MedicineAstrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta ...
Junhyung Kim +3 more
doaj +1 more source
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Advances in the pathogenesis of Rett syndrome using cell models
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022 Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley +1 more source