Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives
Advanced Photonics Research, EarlyView.Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka +5 more
wiley +1 more source
Advanced Sensor Research, EarlyView.Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol +3 more
wiley +1 more source
Pathological phenotypes of astrocytes in Alzheimer’s disease
Experimental and Molecular MedicineAstrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta ...
Junhyung Kim +3 more
doaj +1 more source
A Systematic Approach to Analyze T Cell Migration: Application to Mouse Melanoma Tumors
Advanced Therapeutics, EarlyView.The results show that a minimum of two migration speeds can be rigorously identified from the data with cells switching between a fast, persistent migratory state, and a slow, random migration state. These results will help in identifying genetic factors that influence rapid migration, among other applications, such as quality control for CAR‐T cell ...
Nikolaos Memmos +4 more
wiley +1 more source
Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice
Acta Pharmaceutica Sinica BSpinal microglia and astrocytes are both involved in neuropathic and inflammatory pain, which may display sexual dimorphism. Here, we demonstrate that the sustained activation of spinal astrocytes and astrocyte-derived interleukin (IL)-17A promotes the ...
Huizhu Liu +6 more
doaj +1 more source
Use of an in vitro system to study the effects of lead on astrocyte-endothelial cell interactions: A model for studying toxic injury to the blood-brain barrier [PDF]
, 1988 Ann Marie Gebhart, Gary W. Goldstein
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LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
Acetoacetate and glucose as substrates for lipid synthesis by rat brain oligodendrocytes and astrocytes in serum-free culture [PDF]
, 1984 Jan W. Koper +3 more
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Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity
Advanced Science, EarlyView.This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong +16 more
wiley +1 more source
Heparin inhibits the growth of astrocytes in vitro [PDF]
, 1988 Patricia L. Robertson, Gary W. Goldstein
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