Results 231 to 240 of about 461,223 (386)
Parabiosis, Assembloids, Organoids (PAO)
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source
Correction: Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cells. [PDF]
Hu X, Han S, Li Z, Li Y, Gao J.
europepmc +1 more source
Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex [PDF]
Benjamin K. Lau +6 more
openalex +1 more source
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang +16 more
wiley +1 more source
<i>In vitro</i> 3D models of neuron-astrocyte interactions. [PDF]
Su T, Li Z, Yang Y, Dai Y, Li Y, Zhao H.
europepmc +1 more source
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source

