Results 231 to 240 of about 303,608 (351)

Protective mechanisms against Alzheimer's disease in APOE3-Christchurch homozygous astrocytes. [PDF]

Alzheimers Dement
Tian X, Rivera EK, Hwang I, Nikitina AA, Smith JA, Cho YJ, Sala-Jarque J, DuBose A, Andriola C, Gollan-Myers T, Kosik KS.   +10 more
europepmc   +1 more source

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

, 1994
Andrea Volterra, Davide Trotti, Cinzia Tromba, STEFANO FLORIDI, Giorgio Racagni   +4 more
openalex   +1 more source

Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain. [PDF]

, 1991
Colin Sumners, Wei Tang, Blanka Železná, Mohan K. Raizada   +3 more
openalex   +1 more source

Astrocytes as Metabolic Sensors Orchestrating Energy-Driven Brain Vulnerability in Alzheimer's Disease. [PDF]

J Neurochem
Sánchez de Muniain L, Escalada P, Ramírez MJ, Solas M.   +3 more
europepmc   +1 more source

Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury

Advanced Science, EarlyView.
This study demonstrates that combining Ce0.7Zr0.3O2 nanozymes with nimodipine enhances neuroprotection after traumatic brain injury. The therapy reduces oxidative stress, neuronal apoptosis, and improves blood–brain barrier integrity, with nanozymes effective at low doses.
Xinjie Hong, Liang Zhao, Xianzheng Sang, Chao Ma, Meiqi Chang, Xinran Song, Wei Feng, Tao Xu, Li Ding, Yu Chen, Lijun Hou   +10 more
wiley   +1 more source

Inhibition of astrocyte proliferation and binding to brain tissue of anticardiolipin antibodies purified from lupus serum. [PDF]

, 1992
Kuang‐Hui Sun, W T Liu, Chang‐Youh Tsai, Tang-Shueen Liao, Whu-Mei Lin, Chia‐Li Yu   +5 more
openalex   +1 more source

Modeling neuron-astrocyte interactions in neural networks using distributed simulation. [PDF]

PLoS Comput Biol
Jiang HJ, Aćimović J, Manninen T, Ahokainen I, Stapmanns J, Lehtimäki M, Diesmann M, van Albada SJ, Plesser HE, Linne ML.   +9 more
europepmc   +1 more source

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Advanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan, Enikő Zakar‐Polyák, Anita Adami, Anna A. Abbas, Yogita Sharma, Raquel Garza, Jenny G. Johansson, Diahann A. M. Atacho, Éva Renner, Miklós Palkovits, Csaba Kerepesi, Johan Jakobsson, Karolina Pircs   +12 more
wiley   +1 more source

Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Neurodegeneration in Alzheimer's Disease Mice Model 5xFAD. [PDF]

Neural Plast
Gerasimov E, Berg M, Bolshakova A, Bezprozvanny I, Vlasova O.   +4 more
europepmc   +1 more source