Results 231 to 240 of about 462,755 (380)

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability. [PDF]

Glia
Popek M, Goryca K, Adamska D, Urban-Ciećko J, Hryniewiecka K, Lipiec M, Krawczyk TG, Rafalko K, Ławicka A, Liddelow SA, Szewczyk LM.   +10 more
europepmc   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes. [PDF]

Glia
Basak S, Colafrancesco AM, Hernandez RD, Wei X, McMeekin LJ, Dang D, Simmons M, Browning JL, Noel K, Zhou F, Lund FE, Saad JS, Watsen SG, Pickrell AM, Cowell RM, Olsen ML.   +15 more
europepmc   +1 more source

Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice

Yonggang Fan, Ri‐Le Ge, Hang Ren, Rong‐Jun Jia, Ting-Yao Wu, Xian-Fang Lei, Zheng Wu, Xiao-Bei Zhou, Zhan‐You Wang   +8 more
openalex   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

MAFG Induces the Methylation of CRYAB to Promote the Activation of A1 Astrocyte After Spinal Cord Injury. [PDF]

Immun Inflamm Dis
Li X, Zhu Z, Wang Y, Wan H, Wang Z, Qiao W.   +5 more
europepmc   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Astrocyte epigenetics as a priority area in neuroscience research. [PDF]

Front Mol Neurosci
Morales Pantoja IE, Mintz CD.
europepmc   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Interleukin-9 Regulates NF-kB-Mediated Activation of Astrocytes in Multiple Sclerosis Brain. [PDF]

Neurol Neuroimmunol Neuroinflamm
Cinotti M, Amadio S, Tidei D, Donninelli G, Stacchiotti C, De Paolis V, Colombo E, De Angelis A, Ruffini F, Martino G, Farina C, Parisi C, Volonté C, Volpe E.   +13 more
europepmc   +1 more source