Results 271 to 280 of about 440,890 (382)

Effect of Dibutyryl Cyclic AMP-Treatment on Prostaglandin F2-Stimulated Phosphoinositide Hydrolysis in Cultural Rat Astrocytes

, 1992
Junichi Kitanaka, Akemichi Baba
openalex   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

Comment on "Changes in iPSC-Astrocyte Morphology Reflect Alzheimer's Disease Patient Clinical Markers". [PDF]

Stem Cells
Paudel L.
europepmc   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Astrocytes at the heart of sleep: from genes to network dynamics. [PDF]

Cell Mol Life Sci
Bellier F, Walter A, Lecoin L, Chauveau F, Rouach N, Rancillac A.   +5 more
europepmc   +1 more source

Activation of Ca2+/calmodulin-dependent protein kinase II and phosphorylation of intermediate filament proteins by stimulation of glutamate receptors in cultured rat cortical astrocytes.

, 1994
S. Yano, Kohji Fukunaga, Y Ushio, E. Miyamoto   +3 more
openalex   +1 more source

Effects of General Anesthetics on Intercellular Communications Mediated by Gap Junctions between Astrocytes in Primary Culture [PDF]

, 1993
Jean Mantz, Jocelyne Cordier, Christian Giaume   +2 more
openalex   +1 more source

Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?

Advanced Science, EarlyView.
Despite advancements in implantable electrode technology, challenges persist in scaling up these devices to record most of the neuronal activity across the cortex. This review explores the limitations of both rigid and flexible probes, including tissue damage and foreign body response, while also discussing emerging biohybrid strategies.
Attila Kaszás, Domokos Meszéna, Richárd Fiáth, Andrea Slézia, István Ulbert, Gergely Katona   +5 more
wiley   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Astrocyte-driven vasoconstriction impairs glymphatic clearance in a human tauopathy-on-chip model. [PDF]

APL Bioeng
Park R, Peng Y, Yslas AR, Lee E.
europepmc   +1 more source