Results 61 to 70 of about 123,114 (319)
Astrocyte-induced positive integrated information in neuroglial ensembles [PDF]
Phys. Rev. E 99, 012418 (2019), 2018 The Integrated Information is a quantitative measure from information theory how tightly all parts of a system are interconnected in terms of information exchange. In this study we show that astrocyte, playing an important role in regulation of information transmission between neurons, may contribute to a generation of positive Integrated Information ...
arxiv +1 more source
Mitochondrial dynamics in astrocytes [PDF]
Biochemical Society Transactions, 2014 Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca2+) levels in response to synaptic activity. Astrocyte Ca2+ elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons.
Stephen, TL +2 more
openaire +4 more sources
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Transfer of mitochondria from astrocytes to neurons after stroke
Nature, 2016 Neurons can release damaged mitochondria and transfer them to astrocytes for disposal and recycling. This ability to exchange mitochondria may represent a potential mode of cell-to-cell signalling in the central nervous system.
K. Hayakawa +7 more
semanticscholar +1 more source
Astrocyte-Enabled Advancements in Spiking Neural Networks for Large Language Modeling [PDF]
arXiv, 2023 Within the complex neuroarchitecture of the brain, astrocytes play crucial roles in development, structure, and metabolism. These cells regulate neural activity through tripartite synapses, directly impacting cognitive processes such as learning and memory. Despite the growing recognition of astrocytes' significance, traditional Spiking Neural Network (
arxiv
Graphene oxide upregulates the homeostatic functions of primary astrocytes and modulates astrocyte-to-neuron communication [PDF]
Nano Lett. 2018, 18, 9, 5827-5838, 2018 Graphene-based materials are the focus of intense research efforts to devise novel theranostic strategies for targeting the central nervous system. In this work, we have investigated the consequences of long-term exposure of primary rat astrocytes to pristine graphene (GR) and graphene oxide (GO) flakes.
arxiv +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Introducing Astrocytes on a Neuromorphic Processor: Synchronization, Local Plasticity and Edge of Chaos [PDF]
ACM Proceeding NICE '19 Proceedings of the 7th Annual
Neuro-inspired Computational Elements Workshop, 2019, 2019 While there is still a lot to learn about astrocytes and their neuromodulatory role in the spatial and temporal integration of neuronal activity, their introduction to neuromorphic hardware is timely, facilitating their computational exploration in basic science questions as well as their exploitation in real-world applications.
arxiv +1 more source
Ultrastructural view of astrocyte-astrocyte and astrocyte-synapse contacts within the hippocampus [PDF]
, 2020 SummaryAstrocytes branch out and make contact at their interfaces. However, the ultrastructural interactions of astrocytes and astrocytes with their surroundings, including the spatial-location selectivity of astrocyte-synapse contacts, remain unknown. Here, the branching architecture of three neighboring astrocytes, their contact interfaces, and their
Emily P. Arzola +14 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source