Results 61 to 70 of about 303,608 (351)

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Cell Proliferation, 2020
Central nervous system (CNS) maintains a high level of metabolism, which leads to the generation of large amounts of free radicals, and it is also one of the most vulnerable organs to oxidative stress.
Yaxing Chen, C. Qin, Jianhan Huang, Xin Tang, Chang Liu, Keru Huang, Jianguo Xu, G. Guo, A. Tong, Liangxue Zhou   +9 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

Journal of Neuroinflammation, 2020
Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear.
He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu, Xiao-Xia Jiang   +10 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

New Insights into GFAP Negative Astrocytes in Calbindin D28k Immunoreactive Astrocytes

Brain Sciences, 2018
Glial fibrillary acidic protein (GFAP) is commonly used as a specific marker for the identification of astrocytes. Nevertheless, it is known from the literature that astrocytes in situ in contrast to cultured astrocytes may feature lower levels of GFAP ...
Jie Xu
doaj   +1 more source

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

Journal of Pharmacological Sciences, 2020
The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD).
Moonseok Choi, Hyunju Kim, Eun-Jeong Yang, Hye-Sun Kim   +3 more
doaj   +1 more source

Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides

Frontiers in Psychiatry, 2021
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide.
Liam Anuj O'Leary, Liam Anuj O'Leary, Claudia Belliveau, Claudia Belliveau, Maria Antonietta Davoli, Jie Christopher Ma, Arnaud Tanti, Gustavo Turecki, Gustavo Turecki, Gustavo Turecki, Naguib Mechawar, Naguib Mechawar, Naguib Mechawar   +12 more
doaj   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

Astrocyte morphology

Trends in Cell Biology
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse ...
Baldwin, Katherine T, Murai, Keith K, Khakh, Baljit S   +2 more
openaire   +4 more sources

Ultrastructural view of astrocyte-astrocyte and astrocyte-synapse contacts within the hippocampus [PDF]

, 2020
SummaryAstrocytes branch out and make contact at their interfaces. However, the ultrastructural interactions of astrocytes and astrocytes with their surroundings, including the spatial-location selectivity of astrocyte-synapse contacts, remain unknown. Here, the branching architecture of three neighboring astrocytes, their contact interfaces, and their
Emily P. Arzola, Min Zhou, Anne T. Taylor, Emily Benson, Elizabeth Gerviacio Camacho, Devin Mediratta, Yixing Du, Sydney Aten, Jeremy Patterson, Grahame J. Kidd, Kelsey A Collins, Conrad M. Kiyoshi, Ally M. Guiher, Merna Philip, David Terman   +14 more
openaire   +2 more sources