Results 71 to 80 of about 303,608 (351)

Hydrogen Peroxide-Induced Thymidine Incorporation Into Cultured Rat Astrocytes

Journal of Pharmacological Sciences, 2006
We characterized [methyl-3H]thymidine ([3H]thymidine) and [5-3H]uridine ([3H]uridine) incorporation into cultured astrocytes and neurons in the presence and absence of hydrogen peroxide (H2O2) in order to define the response to oxidative stress in the ...
Koh-ichi Tanaka, Tomoaki Sato, Yoshiko Ohnishi, Takashige Nishikawa   +3 more
doaj   +1 more source

Astrocytes: GABAceptive and GABAergic Cells in the Brain

Frontiers in Cellular Neuroscience, 2022
Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of neurological disorders.
Jianhui Liu, Xuanran Feng, Yi Wang, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng   +11 more
doaj   +1 more source

Transfer of mitochondria from astrocytes to neurons after stroke

Nature, 2016
Neurons can release damaged mitochondria and transfer them to astrocytes for disposal and recycling. This ability to exchange mitochondria may represent a potential mode of cell-to-cell signalling in the central nervous system.
K. Hayakawa, E. Esposito, Xiaohua Wang, Y. Terasaki, Yi Liu, Changhong Xing, X. Ji, E. Lo   +7 more
semanticscholar   +1 more source

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
wiley   +1 more source

Astrocytic control in in vitro and simulated neuron-astrocyte networks

Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication, 2021
Astrocytes are involved in the information propagation in the brain by interacting with neurons. Computational modeling helps to study the underlying mechanisms for this communication deeply. In this work, we aimed to analyze how the number of astrocytes and the resulting astrocytic network structure affects neuronal activity.
Genocchi, Barbara, Ahtiainen, Annika, Barros, Michael Taynnan, Tanskanen, Jarno, Hyttinen, Jari, Lenk, Kerstin   +5 more
openaire   +3 more sources

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons

Journal of Neuroinflammation, 2018
Background Most neurodegenerative diseases associated with protein aggregation are hallmarked by activation of astrocytes. However, how astrocytes are activated or which signaling pathways in astrocytes contribute to pathogenesis is not clear.
Y. X. Li, O. C. M. Sibon, P. F. Dijkers
doaj   +1 more source

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons

Frontiers in Cell and Developmental Biology, 2023
Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD ...
Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Martin Montecino, Brigitte van Zundert, Brigitte van Zundert   +19 more
doaj   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Mitochondrial dynamics in astrocytes [PDF]

Biochemical Society Transactions, 2014
Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca2+) levels in response to synaptic activity. Astrocyte Ca2+ elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons.
Stephen, TL, Gupta-Agarwal, S, Kittler, JT   +2 more
openaire   +4 more sources