Results 71 to 80 of about 461,223 (386)

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

Journal of Neuroinflammation, 2020
Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear.
He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu, Xiao-Xia Jiang   +10 more
doaj   +1 more source

Astrocytes: GABAceptive and GABAergic Cells in the Brain

Frontiers in Cellular Neuroscience, 2022
Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of neurological disorders.
Jianhui Liu, Xuanran Feng, Yi Wang, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng   +11 more
doaj   +1 more source

Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]

, 2013
NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H, Deng, W, Guo, F, Jiang, P, Pleasure, DE   +4 more
core   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Brain pericytes upregulate glutamate uptake by astrocytes in vitro through sodium-dependent transporter

IBRO Neuroscience Reports
Astrocytes maintain glutamate homeostasis in the central nervous system (CNS) via glutamate uptake through Na+-dependent excitatory amino acid transporters (EAAT1 and EAAT2), and this process is regulated by several CNS cell types. However, it is unclear
Kenta Sakai, Fuyuko Takata, Takuro Iwao, Miho Yasunaga, Gaku Yamanaka, Yasufumi Kataoka, Shinya Dohgu   +6 more
doaj   +1 more source

Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. [PDF]

, 2018
Reactive astrocytes influence post-injury recovery, repair, and pathogenesis of the mammalian CNS. Much of the regulation of astrocyte reactivity, however, remains to be understood.
Carolino, Krislyn I, Chen, Meifan, Elzière, Lucie, Geoffroy, Cédric G, Goldberg, Mark P, Jin, Yishi, Khai, Vung S, Kong, Xiangmei, Li, Yunbo, Meves, Jessica M, Narang, Aarti, Nguyen, Mallorie T, Steinke, Christopher L, Zheng, Binhai   +13 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

New Insights into GFAP Negative Astrocytes in Calbindin D28k Immunoreactive Astrocytes

Brain Sciences, 2018
Glial fibrillary acidic protein (GFAP) is commonly used as a specific marker for the identification of astrocytes. Nevertheless, it is known from the literature that astrocytes in situ in contrast to cultured astrocytes may feature lower levels of GFAP ...
Jie Xu
doaj   +1 more source

Direct vascular contact is a hallmark of cerebral astrocytes

Cell Reports, 2022
Summary: Astrocytes establish extensive networks via gap junctions that allow each astrocyte to connect indirectly to the vasculature. However, the proportion of astrocytes directly associated with blood vessels is unknown.
Ladina Hösli, Marc Zuend, Gustav Bredell, Henri S. Zanker, Carlos Eduardo Porto de Oliveira, Aiman S. Saab, Bruno Weber   +6 more
doaj   +1 more source

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

Cells, 2021
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others.
Pranav Preman, Maria Alfonso-Triguero, E. Alberdi, A. Verkhratsky, Amaia M. Arranz   +4 more
semanticscholar   +1 more source