Results 81 to 90 of about 123,114 (319)

The Matrix Receptor CD44 Is Present in Astrocytes throughout the Human Central Nervous System and Accumulates in Hypoxia and Seizures

Cells
In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter but not in protoplasmic astrocytes.
Osama Al-Dalahmah, Alexander A. Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E. Sander Connolly, Carol M. Troy, Guy M. McKhann, James E. Goldman   +8 more
doaj   +1 more source

TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer’s diseases

Redox Biology, 2023
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of Alzheimer’s disease (AD). Neuroinflammation and oxidative stress are associated with neuronal death in AD. Astrocytes are linked to neuroinflammation during AD. Astrocytes
Junhyung Kim, Jaejoon Lim, Ik Dong Yoo, Samel Park, Jong-Seok Moon   +4 more
doaj  

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons

Frontiers in Cell and Developmental Biology, 2023
Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD ...
Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Martin Montecino, Brigitte van Zundert, Brigitte van Zundert   +19 more
doaj   +1 more source

Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual‐phase 11C‐PiB PET detects amyloid deposition and cerebral perfusion changes and may have diagnostic value for identifying tau in CAA ...
Meng‐Ting Chiang, Chia‐Ju Liu, Bo‐Ching Lee, Ruoh‐Fang Yen, Hsin‐Hsi Tsai   +4 more
wiley   +1 more source

Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer

Acta Neuropathologica Communications, 2020
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in vitro ...
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen   +5 more
doaj   +1 more source

Hemisynapse Formation Between Target Astrocytes and Cortical Neuron Axons in vitro

Frontiers in Molecular Neuroscience, 2022
One of the most fundamental organizing principles in the mammalian brain is that neurons do not establish synapses with the other major cell type, the astrocytes.
Zenghui Teng, Kurt Gottmann
doaj   +1 more source

Astrocyte-Integrated Dynamic Function Exchange in Spiking Neural Networks [PDF]

arXiv, 2023
This paper presents an innovative methodology for improving the robustness and computational efficiency of Spiking Neural Networks (SNNs), a critical component in neuromorphic computing. The proposed approach integrates astrocytes, a type of glial cell prevalent in the human brain, into SNNs, creating astrocyte-augmented networks.
arxiv  

Pathology and Astrocytes in Autism

Neuropsychiatric Disease and Treatment, 2023
A distinct pathology for autism spectrum disorder (ASD) remains elusive. Human and animal studies have focused on investigating the role of neurons in ASD. However, recent studies have hinted that glial cell pathology could be a characteristic of ASD.
Vakilzadeh,Gelareh, Martinez-Cerdeño,Veronica   +1 more
openaire   +4 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment

Journal of Neuroinflammation, 2020
Background Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear.
He-Yang Zhang, Yan Wang, Youdi He, Ting Wang, Xiao-Hui Huang, Chang-Ming Zhao, Lei Zhang, Si-Wei Li, Changyong Wang, Yan-Nv Qu, Xiao-Xia Jiang   +10 more
doaj   +1 more source