Results 11 to 20 of about 75,763 (246)
A Case of IDH-Mutant Astrocytoma Harboring an IDH2 R172_H173delinsSN Variant. [PDF]
NeuropathologyABSTRACT IDH‐mutant gliomas most commonly harbor the canonical IDH1 p.R132H mutation, followed by less common mutations involving IDH1 p.R132 or IDH2 p.R172 codons. We present a case of a 32‐year‐old male found to have a left temporal brain tumor with regional enhancement on brain MRI, for which he underwent resection.
Auen T, Chen J, Shonka N, Cathcart S.
europepmc +2 more sources
Infratentorial IDH-mutant astrocytoma is a distinct subtype
Acta Neuropathologica, 2020 Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In this multi-institutional study, we characterized a series of primary infratentorial IDH-mutant astrocytic tumors with respect to clinical and molecular ...
Rouzbeh Banan +26 more
semanticscholar +1 more source
Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence
npj Precision Oncology, 2023 Astrocytoma and glioblastoma (GB) are reclassified subtypes of adult diffuse gliomas based on distinct isocitrate dehydrogenase (IDH) mutation in the fifth edition of the WHO Classification of Tumors of the Central Nervous System.
Jinsen Zhang +16 more
doaj +1 more source
Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma [PDF]
Neurospine, 2023 Objective Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported.
Lei Cheng +9 more
doaj +1 more source
Acta Neuropathologica Communications, 2023 In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive.
Kensuke Tateishi +15 more
doaj +1 more source
Expression of delta-catenin is associated with progression of human astrocytoma
BMC Cancer, 2011 Background δ-Catenin (CTNND2), which encodes a scaffold protein in humans, has been found in a few malignancies. However, the expression pattern and contribution of δ-catenin to astrocytoma progression are unclear.
MingHao Wang +3 more
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SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis
BMC Cancer, 2020 Background Astrocytoma is a common tumor type in primary central nervous system and has a high death rate around the world. Aberrant expression of long non-coding RNAs (lncRNAs) has been introduced by emerging studies to result in the development of ...
Fengping Du, Qian Hou
doaj +1 more source
Indian Journal of Pathology and Microbiology, 2010 Pilomyxoid astrocytoma (PMA) is a recently described brain tumor. PMA shares similar features with pilocytic astrocytoma (PA), the most common central nervous system (CNS) tumor in the pediatric population, yet displays subtle histologic differences.
Azad Sheenam +6 more
openaire +3 more sources
Cancer Reports, 2023 Background A form of cancer called astrocytoma can develop in the brain or spinal cord and sometimes causes death. A detailed overview of the precise signaling cascade underlying astrocytoma formation has not yet been revealed, although various factors ...
Chowdhury Lutfun Nahar Metu +8 more
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Importance of GFAP isoform‐specific analyses in astrocytoma
Glia, 2019 Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have
E. V. van Bodegraven +3 more
semanticscholar +1 more source