Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]
, 2010 Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad +6 more
core +5 more sources
Expression of delta-catenin is associated with progression of human astrocytoma
BMC Cancer, 2011 Background δ-Catenin (CTNND2), which encodes a scaffold protein in humans, has been found in a few malignancies. However, the expression pattern and contribution of δ-catenin to astrocytoma progression are unclear.
MingHao Wang +3 more
doaj +1 more source
Cancer Reports, 2023 Background A form of cancer called astrocytoma can develop in the brain or spinal cord and sometimes causes death. A detailed overview of the precise signaling cascade underlying astrocytoma formation has not yet been revealed, although various factors ...
Chowdhury Lutfun Nahar Metu +8 more
doaj +1 more source
Bilateral thalamic astrocytoma [PDF]
Journal of Neuro-Oncology, 2007 We present a 68-year-old woman who presented with symptoms of frontotemporal dementia. Brain MRI revealed tumor mass in both thalami and according to WHO classification, the tumor corresponded to diffuse fibrillary astrocytoma grade II. This case points to the role of neuroimaging in patients presenting with classical symptoms of dementia.
Habek, Mario +4 more
openaire +6 more sources
Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas [PDF]
, 2018 Pilocytic astrocytomas represent the most common glioma subtype in young patients and account for 5.4% of all gliomas. They are characterized by alterations in the RAS–MAP kinase pathway, the most frequent being a tandem duplication on chromosome 7q34 ...
Appay, Romain +13 more
core +2 more sources
Importance of GFAP isoform‐specific analyses in astrocytoma
Glia, 2019 Gliomas are a heterogenous group of malignant primary brain tumors that arise from glia cells or their progenitors and rely on accurate diagnosis for prognosis and treatment strategies. Although recent developments in the molecular biology of glioma have
E. V. van Bodegraven +3 more
semanticscholar +1 more source
Crossed Aphasia in a Patient with Anaplastic Astrocytoma of the Non-Dominant Hemisphere [PDF]
, 2017 Aphasia describes a spectrum of speech impairments due to damage in the language centers of the brain. Insult to the inferior frontal gyrus of the dominant cerebral hemisphere results in Broca\u27s aphasia - the inability to produce fluent speech.
Anand, Neil +3 more
core +2 more sources
Journal of Biomedical Science, 2012 Background Astrocytomas are cancers of the brain in which high levels of extracellular glutamate plays a critical role in tumor growth and resistance to conventional treatments.
Varini Karine +6 more
doaj +1 more source
Recurrent Optic Nerve Pilocytic Astrocytoma: A Rare Case [PDF]
Journal of Clinical and Diagnostic Research, 2017 Pilocytic astrocytoma is a low grade glioma that affects mostly children and young adults and can occur anywhere in the central nervous system. Pilocytic astrocytoma of the optic nerve is an equally indolent subtype that is often associated with ...
SUDHA GIRISH MENON +3 more
doaj +1 more source
Transcriptome analysis reveals distinct gene expression profiles in astrocytoma grades II-IV
Biomedical Papers, 2017 Background: Astrocytoma is the most prevalent form of primary brain cancer categorized into four histological grades by the World Health Organization. Investigation into individual grades of astrocytoma by previous studies has provided some insight into ...
Nato Narsia +3 more
doaj +1 more source