Results 31 to 40 of about 75,763 (246)

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Clinical Cancer Research, 2018
Purpose: Pilocytic astrocytoma is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced senescence (OIS), which may cause unpredictable growth behavior of pilocytic astrocytomas. The
J. Buhl, J. Buhl, F. Selt, F. Selt, T. Hielscher, Romain Guiho, J. Ecker, J. Ecker, F. Sahm, F. Sahm, J. Ridinger, J. Ridinger, D. Riehl, D. Usta, B. Ismer, B. Ismer, A. Sommerkamp, A. Sommerkamp, J. Martínez-Barbera, A. Wefers, A. Wefers, M. Remke, M. Remke, D. Picard, D. Picard, Stefan Pusch, Stefan Pusch, J. Gronych, I. Oehme, C. M. Tilburg, C. M. Tilburg, M. Kool, Daniel Kuhn, David Capper, David Capper, David Capper, A. Deimling, A. Deimling, M. Schuhmann, C. Herold‐Mende, A. Korshunov, A. Korshunov, T. Brummer, Stefan M. Pfister, Stefan M. Pfister, David T. W. Jones, Olaf Witt, Olaf Witt, T. Milde, T. Milde   +49 more
semanticscholar   +1 more source

Human epidermal growth factor receptor 2 neu and E-cadherin expression in primary astrocytic brain tumors as prognostic biomarkers

Al-Azhar Assiut Medical Journal, 2021
Background The primary brain tumors including astrocytic tumors, ranging from circumscribed into diffuse and glioblastoma (GBM), which is considered as a highly malignant neoplasm of the central nervous system.
Mohamed Y Ali, Marwa A El Kholy
doaj   +1 more source

The Diagnostic Significance of CXCL13 in M2 Tumor Immune Microenvironment of Human Astrocytoma

Pathology and Oncology Research, 2022
Background: CXCL13 may act as a mediator of tumor-associated macrophage immunity during malignant progression.Objective: The present study clarifies the clinicopathological significances of CXCL13 and its corresponding trend with M2 macrophage in human ...
Shu-Jyuan Chang, Shu-Jyuan Chang, Chia-Te Chao, Aij-Lie Kwan, Aij-Lie Kwan, Chee-Yin Chai, Chee-Yin Chai, Chee-Yin Chai   +7 more
doaj   +1 more source

Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma. [PDF]

PLoS ONE, 2017
Astrocytoma is the most common type of primary malignant brain tumor, with pretty lowly 5-year survival rate in patients. Although extended surgical removal of the tumor and postoperative chemotherapy/radiotherapy executed, still there is large ...
Weibing Fan, Shuang-Shi Fan, Juan Feng, Desheng Xiao, Songqing Fan, Jiadi Luo   +5 more
doaj   +1 more source

SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B

Journal of Hematology & Oncology, 2017
BackgroundSIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our previous study showed that the SIX3 gene is hypermethylated, and its expression is decreased
Zhibin Yu, Yingnan Sun, X. She, Zeyou Wang, Shuai Chen, Zhiyong Deng, Yan Zhang, Qiang Liu, Qing Liu, Chunhua Zhao, Peiyao Li, Changhong Liu, Jianbo Feng, Haijuan Fu, Guiyuan Li, Minghua Wu   +15 more
semanticscholar   +1 more source

Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma

Scientific Reports, 2021
Astrocytoma is the most common glial tumour of the CNS. The most malignant form is grade IV Astrocytoma, also called Glioblastoma. Due to its heterogeneity, aggressiveness and lethal nature scientists are trying to find less invasive methods for early ...
Rūta Urbanavičiūtė, Rūta Zabitaitė, Algimantas Kriščiukaitis, Vytenis-Pranas Deltuva, Daina Skiriutė   +4 more
doaj   +1 more source

In silico analysis identifies a putative cell-of-origin for BRAF fusion-positive cerebellar pilocytic astrocytoma.

PLoS ONE, 2020
Childhood cancers are increasingly recognized as disorders of cellular development. This study sought to identify the cellular and developmental origins of cerebellar pilocytic astrocytoma, the most common brain tumor of childhood.
Subhi Talal Younes, Betty Herrington
doaj   +2 more sources

Pilocytic astrocytoma: pathology, molecular mechanisms and markers

Acta Neuropathologica, 2015
Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over 90 %.
V. Collins, David T. W. Jones, C. Giannini   +2 more
semanticscholar   +1 more source

Expression of Ki 67 and P53 immunohistochemical markers in central nervous system astrocytoma

مجلة كلية الطب, 2015
Background: Astrocytic tumors are the most common primary tumors of the central nervous system. Several grading systems are used to grade astrocytomas.
Mahmood Sh. Mahmood, Khitam R. Kadhim Al – Khafaji   +1 more
doaj   +1 more source

MicroRNA‐124‐3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma

Cancer Science, 2016
The PIM1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and metabolism in various human cancers. MicroRNAs (miRNAs) are powerful post‐transcriptional gene regulators that function through translational repression or ...
Danni Deng, Lei Wang, Yao Chen, Bowen Li, Lian Xue, N. Shao, Qiang Wang, X. Xia, Yilin Yang, F. Zhi   +9 more
semanticscholar   +1 more source