Results 81 to 90 of about 2,602 (175)

Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, and associated metabolic comorbidities: A systematic review

Liver International, Volume 44, Issue 5, Page 1075-1092, May 2024.
Abstract Background and Aims The beneficial effect of Hepatitis C virus (HCV) eradication by direct antiviral agents (DAAs) on liver fibrosis is well defined. Despite this, the impact of viral eradication in both hepatic and extra‐hepatic metabolic features is underreached.
Annalisa Cespiati, Inês Coelho Rodrigues, Inês Santos, Sara Policarpo, Sofia Carvalhana, Anna Ludovica Fracanzani, Helena Cortez‐Pinto   +6 more
wiley   +1 more source

Rapid, direct, and sensitive determination of aziridine and 2-chloroethylamine by hydrophilic interaction liquid chromatography-mass spectrometry

MethodsX, 2019
A rapid HILIC-MS method was developed for measuring the genotoxic impurities aziridine and 2-chloroethylamine. Sample preparation was simple and direct without requiring derivatization.
Jonathan G. Shackman
doaj   +1 more source

Small‐Molecule Regulators for Gene Switches to Program Mammalian Cell Behaviour

ChemBioChem, Volume 25, Issue 6, March 15, 2024.
Small molecules have been widely utilized within the synthetic biology community as trigger input for regulating implemented genetic circuit in engineered mammalian cells. Here, we described the most commonly used small molecules and their associated genetic switches, employed to program cell behaviors, particularly within a cell and gene therapy ...
Maysam Mansouri, Martin Fussenegger
wiley   +1 more source

NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2015
The aim of review. To analyze antiviral activity of a new NS5A replication complex inhibitor daclatasvir in patients with chronic HCV-infection in relation to different genotypes, including patients with failure of previous antiviral therapy, with liver ...
M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin   +2 more
doaj  

A Hepatitis C Virus-Associated Chronic Hepatitis Patient Developing Various Adverse Events Including Severe Gingivitis, Gingival Bleeding, and Inflammation of Genital Vulva during the Course of Antiviral Therapy with Elbasvir/Grazoprevir

Case Reports in Gastroenterology, 2017
Oral direct-acting antivirals comprise the main therapy for hepatitis C virus (HCV)-associated liver disease in Japan. Daclatasvir/asunaprevir is the primary agent and sofosbuvir/ledipasvir is the secondary agent for HCV genotype 1b.
Kazuo Tarao, Akira Sato
doaj   +1 more source

APASL consensus statements and recommendations for hepatitis C prevention, epidemiology, and laboratory testing [PDF]

, 2016
The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on “APASL consensus statements and recommendations for management of hepatitis C” in March 2015 to revise the “APASL consensus statements and ...
A. Kadir Dokmeci, Alaaeldin Ibrahim, Ankur Jindal, Barjesh Chander Sharma, Cosmas Rinaldi Adithya Lesmana, Darrell H. G. Crawford, Geofferey W. McCaughan, George K. K. Lau, Jafri Wasim, Jia-Horng Kao, Jose Sollano, Lai Wei, Mamun Al-Mahtab, Manoj Kumar, Masao Omata, Ming-Lung Yu, Osamu Yokosuka, Saeed S. Hamid, Shiv Kumar Sarin, Tatsuo Kanda, Wang-Long Chuang   +20 more
core   +1 more source

Reaction Space Charting as a Tool in Organic Chemistry Research and Development

Advanced Synthesis &Catalysis, Volume 366, Issue 4, Page 551-573, February 20, 2024.
Abstract The chemical and reaction spaces are incredibly vast and special procedures are required to study them. Their complex and multiparametric nature encompass myriads of compounds and interactions and endless modifications involving the distinct impact of relevant variables (temperature, solvent, stoichiometry, etc.).
Eloy Lozano Baró, Pau Nadal Rodríguez, Jordi Juárez‐Jiménez, Ouldouz Ghashghaei, Rodolfo Lavilla   +4 more
wiley   +1 more source

Successful Pre- and Posttransplant Sofosbuvir-Based Anti-Hepatitis C Virus Treatment in Persons Living With Human Immunodeficiency Virus Infection [PDF]

, 2017
This retrospective study reports the data of sofosbuvir-based anti-hepatitis C virus treatment in 24 candidates and 24 recipients of liver transplantation coinfected with human immunodeficiency virus. Sustained virologic response was cumulatively 85% (90%
Badia, Lorenzo, Beghetto, Barbara, Dolci, Giovanni, Guaraldi, Giovanni, Magliano, Anna, Moioli, Maria Cristina, Nardini, Giulia, Pasulo, Luisa, Puoti, Massimo, Rossotti, Roberto, Tavio, Marcello, Verucchi, Gabriella   +11 more
core   +1 more source

Characterization of circulating miRNAs in the treatment of primary liver tumors

Cancer Reports, Volume 7, Issue 2, February 2024.
Abstract Background and Aim Circulating micro RNAs (miRNAs) indicate clinical pathologies such as inflammation and carcinogenesis. In this study, we aimed to investigate whether miRNA expression level patterns in could be used to diagnose hepatocellular carcinoma (HCC) and biliary tract cancer (BTC), and the relationship miRNA expression patterns and ...
Tomohiro Umezu, Shogo Tanaka, Shoji Kubo, Masaru Enomoto, Akihiro Tamori, Takahiro Ochiya, Y.‐H. Taguchi, Masahiko Kuroda, Yoshiki Murakami   +8 more
wiley   +1 more source

HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy

Viruses, 2015
Sustained virological response (SVR) rates have increased dramatically following the approval of direct acting antiviral (DAA) therapies. While individual DAAs have a low barrier to resistance, most patients can be successfully treated using DAA ...
Kazuaki Chayama, C. Nelson Hayes
doaj   +1 more source