Ataxia Telangiectasia Mutated Protein Kinase: A Potential Master Puppeteer of Oxidative Stress‐Induced Metabolic Recycling [PDF]
Oxidative Medicine and Cellular Longevity, 2021 Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis. Best known for its role as a transducer of DNA damage repair, the activity of ATM in the cytosol is enjoying increasing attention, where it plays a central role in general ...
Marguerite Blignaut +3 more
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Huntingtin (HTT); ataxia telangiectasia mutated (ATM); protein kinase Cδ (PRKCD); p53 [PDF]
Science-Business eXchange, 2011 openalex +3 more sources
Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer [PDF]
Clinical Colorectal Cancer, 2018 Loss of ataxia telangiectasia mutated (ATM), a key protein regulating DNA repair signaling, has been suggested to increase sensitivity to DNA damaging agents. We conducted a study analyzing the loss of ATM protein expression in colorectal cancer and correlated this with clinical outcomes.The clinical outcomes data and tumor samples from metastatic ...
Raghav Sundar +20 more
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Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein [PDF]
Proceedings of the National Academy of Sciences, 2011 Stability and repair of DNA is of principal importance in cell survival. Heme oxygenase-1 (HO-1; Hmox1) is critical in maintaining cellular homeostasis, in large part through its ability to generate CO, but neither molecule has been studied in the setting of DNA damage. Naïve Hmox1 − /
Leo E. Otterbein +5 more
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Sensors and Inhibitors for the Detection of Ataxia Telangiectasia Mutated (ATM) Protein Kinase [PDF]
Molecular Pharmaceutics, 2021 Recruitment and activation of the ataxia telangiectasia mutated (ATM) kinase regulate multiple cell-cycle checkpoints relevant to complex biological events like DNA damage repair and apoptosis. Molecularly specific readouts of ATM using protein assays, fluorescence, or radiolabeling have advanced significantly over the past few years.
Cien Huang +3 more
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Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions [PDF]
Proceedings of the National Academy of Sciences, 2011 Antigen receptor variable region exons are assembled during lymphocyte development from variable (V), diversity (D), and joining (J) gene segments. Each germ-line gene segment is flanked by recombination signal sequences (RSs). Recombination-activating gene endonuclease initiates V(D)J recombination by cleaving a pair of gene segments at their junction
Shan Zha +7 more
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The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration [PDF]
Journal of Virology, 2005 ABSTRACT Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the host DNA and insertion of the viral DNA, forming an integration intermediate that contains two gaps, each with a viral 5 ...
Jason L. DeHart +7 more
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Immunoassay to Measure Ataxia-Telangiectasia Mutated Protein in Cellular Lysates [PDF]
Clinical Chemistry, 2004 AbstractBackground: Ataxia-telangiectasia (A-T) is a neurologic disorder caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A clinical diagnosis of A-T is confirmed by radiosensitivity testing and immunoblotting for ATM protein. Because both of these tests have long turnaround times (≥3 months), we developed a rapid immunoassay to ...
Anthony W. Butch +3 more
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Ataxia telangiectasia mutated (ATM); DNA-dependent protein kinase (DNA-PK) [PDF]
Science-Business eXchange, 2013 openalex +3 more sources
514 ATAXIA TELANGIECTASIA MUTATED PROTEIN MODULATES GLUCOSE AND LIPID METABOLISM IN THE HEART [PDF]
European Heart Journal Supplements, 2022 Abstract Background Ataxia Telangiectasia Mutated (ATM) protein kinase is the major sensor of DNA damage response (DDR) and oxidative stress, variously implicated in cellular metabolism. Previous studies on ATM functions in the heart have produced conflicting results.
Roberta Paolillo +10 more
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