Results 91 to 100 of about 13,262,735 (197)

Ataxin-3 Is a Multivalent Ligand for the Parkin Ubl Domain

Biochemistry, 2013
The ubiquitin signaling pathway consists of hundreds of enzymes that are tightly regulated for the maintenance of cell homeostasis. Parkin is an E3 ubiquitin ligase responsible for conjugating ubiquitin onto a substrate protein, which itself can be ubiquitinated.
Bai, Jane J., Safadi, Susan S., Mercier, Pascal, Barber, Kathryn R., Shaw, Gary S.   +4 more
openaire   +2 more sources

Caspase‐mediated proteolysis of the polyglutamine disease protein ataxin‐3 [PDF]

Journal of Neurochemistry, 2004
AbstractSpinocerebellar ataxia type‐3, also known as Machado‐Joseph Disease, is one of many inherited neurodegenerative disorders caused by polyglutamine‐encoding CAG repeat expansions in otherwise unrelated disease genes. Polyglutamine disorders are characterized by disease protein misfolding and aggregation; often within the nuclei of affected ...
Berke, S.J.S., Schmied, F.A.F., Brunt, E.R., Ellerby, L.M., Paulson, H.L.   +4 more
openaire   +2 more sources

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin‐1 in B Cells

Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.
Ataxin‐1 has been recently implicated in B cell regulation in the context of multiple sclerosis pathology. In this study, we used a multiomics pipeline to profile the B cell transcriptome, epigenome, and proteome in response to encephalitogenic challenges.
Jonathan J. Carver, Rachael R. Denbrock, Kristy M. Lau, Tonya N. Zeczycki, Changhong Yin, Weihua Huang, Alessandro Didonna   +6 more
wiley   +1 more source

Chemical Chaperones Reduce Aggregate Formation and Cell Death Caused by the Truncated Machado–Joseph Disease Gene Product with an Expanded Polyglutamine Stretch

Neurobiology of Disease, 2002
Machado–Joseph disease/spinocerebellar ataxia-3 (MJD/SCA-3) is an inherited neurodegenerative disorder caused by expansion of the polyglutamine stretch in the MJD gene-encoded protein ataxin-3.
Hideaki Yoshida, Toshihiro Yoshizawa, Futoshi Shibasaki, Shin'ichi Shoji, Ichiro Kanazawa   +4 more
doaj   +1 more source

Quinazolinone and Phthalazinone Inhibitors of the HDAC6/Ubiquitin Protein–Protein Interaction

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Here, we report the validation and expansion of small‐molecule inhibitors targeting the HDAC6 ZnF‐UBD pocket. Following molecular modeling, hits were synthesized, and candidate compounds were tested in fluorescence polarization of ubiquitin C‐terminal peptide displacement.
Sydney Gordon, Jordi C. J. Hintzen, Sebastian Dilones, Brockton Keen, Callie E. W. Crawford, George M. Burslem   +5 more
wiley   +1 more source

Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.

PLoS ONE, 2010
Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type 3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome pathway.
Giuseppe Nicastro, Sokol V Todi, Ezgi Karaca, Alexandre M J J Bonvin, Henry L Paulson, Annalisa Pastore   +5 more
doaj   +1 more source

The Effect of Protein Tagging on Aggregation and Phase Separation

Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.
ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
wiley   +1 more source

Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels. [PDF]

PLoS ONE, 2010
During myogenesis several transcription factors and regulators of protein synthesis and assembly are rapidly degraded by the ubiquitin-proteasome system (UPS).
Maria do Carmo Costa, Fernanda Bajanca, Ana-João Rodrigues, Ricardo J Tomé, Garry Corthals, Sandra Macedo-Ribeiro, Henry L Paulson, Elsa Logarinho, Patrícia Maciel   +8 more
doaj   +1 more source

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, Volume 41, Issue 6, Page 1516-1527, June 2026.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes, Adriana Marcelo, Ana Teresa Rajado, Rafael G. Costa, Ricardo Afonso‐Reis, Cristiana R. Madeira, Inês T. Afonso, David V.C. Brito, Adriana A. Vaz, Clévio Nóbrega   +9 more
wiley   +1 more source

Ataxin-1 and translationally-controlled tumor protein might be intermediate proteins between Na, K-ATPase and proteasome.

, 2016
(A) Protein-protein interaction network constructed to connect α1, α2 or α3 subunits of Na,K-ATPase and proteasomal-related proteins found in the proteomic study.
Xi Zheng (562208), Qingxi Yue (3152022), Wanying Wu (207392), Baohong Jiang (207398), Lixing Feng (3152019), Min Yang (146229), Xuan Liu (49954), Ming Huang (301457), Dean Guo (207402), Hong Zhen (613026)   +9 more
core   +1 more source