Results 101 to 110 of about 13,262,735 (197)
, 2004 Ataxin-1 is the protein affected in Spinocerebellar Ataxia Type 1 (SCA1) polyglutamine neurodegenerative disease. The biological function of ataxin-1 is unknown. By using live cell fluorescence microscopy and cultured human HeLa cells, we have shown that
Irwin, Stuart
core
The FEBS Journal, Volume 293, Issue 11, Page 3376-3398, June 2026.Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak +10 more
wiley +1 more source
, 2013 (A) Representative cycloheximide “pulse-chase” in Cos7 cells transiently transfected with Flag-tagged ataxin-3(Q22) constructs; ataxin-3 levels are visualized by anti-Flag Western blotting and total protein levels are visualized by Coomassie Brilliant ...
Katerina Dodelzon (360474) +4 more
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Neurobiology of Disease, 2011 In spinocerebellar ataxia-7 (SCA7), a polyglutamine (polyQ) expansion in the ataxin-7 protein leads to the formation of neuronal intranuclear inclusions (NIIs) and neurodegeneration.
Junko Takahashi-Fujigasaki +6 more
doaj +1 more source
Acta Neuropathologica Communications, 2020 Blood-brain barrier (BBB) disruption is a common feature in neurodegenerative diseases. However, BBB integrity has not been assessed in spinocerebellar ataxias (SCAs) such as Machado-Joseph disease/SCA type 3 (MJD/SCA3), a genetic disorder, triggered by ...
Diana Duarte Lobo +8 more
doaj +1 more source
Decoding the Oncogenic Role of USP22 Through Pan‐Cancer Genomic and Epigenetic Analysis
Cancer Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background Ubiquitin‐specific protease 22, an important catalytic component of the human SAGA (Spt‐Ada‐GcN5 Acetyltransferase) complex, regulates the deubiquitination and methylation of histones, which in turn influences gene expression. Its overexpression alters gene regulation, transcription, cancer progression, and therapy resistance.
Uma Devi A., Prakash Kumar Shukla
wiley +1 more source
, 2012 Includes abstract.Includes bibliographical references.Spinocerebellar ataxia type 7 (SCA7) is a dominantly-inherited neurodegenerative disease, resulting from a CAG trinucleotide repeat expansion in the ataxin-7 gene.
Watson, Lauren
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SUMO-1 modification partially increased ataxin-3-68Q stability.
, 2013 HEK293 cells were transfected with GFP-ataxin-3 or GFP-ataxin-3K166R. Immunoblotting analysis showed difference between the soluble (S) and insoluble (I) ataxin-3 in 20Q and 68Q with or without K166 (A).
Kun Xia (9853) +11 more
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Midpoints of ataxin-3(Q64) aggregation.
, 2013 Midpoints of ataxin-3(Q64) aggregation.
Helen M. Saunders (435583) +3 more
core +1 more source
SUMO-1 modification did not affect the subcellular localization of ataxin-3.
, 2013 HEK293 cells were transfected with plasmids expressing GFP-tagged ataxin-3 or mutant ataxin-3K166R in the presence of endogenous SUMO-1. Both ataxin-3-20Q and ataxin-3-20QK166R were localized in the nucleus and cytoplasm uniformly, and the aggregates ...
Kun Xia (9853) +11 more
core +1 more source