Results 231 to 240 of about 30,346 (252)

Gut microbiota-derived indole-3-propionic acid alleviates endoplasmic reticulum stress by regulating FMO2 in MASLD. [PDF]

Hepatol Commun
Luo Y, Zhang Y, Zhang Q, Li X, Cai K, Xu Y, Zhao R, Zhang S, Bai X, Chen H, Li H, Hong Y, Liao Q, Xie Z.   +13 more
europepmc   +1 more source

SIRT2 mediates integrated stress response by deacetylating and stabilizing 4E-BP1 to suppress translation. [PDF]

EMBO Rep
Zi Y, Zhao J, Wang M, Hou D, Cerione RA, Lin H.   +5 more
europepmc   +1 more source

Correction: Optimization extraction of Allium mongolicum Regel polysaccharide and alleviation of intestinal injury via inhibition of the PERK/ATF4/CHOP signaling pathway. [PDF]

Front Vet Sci
Niu X, Nan G, Zheng Y, Chen Y, Jiang H, Zhang J, Chen L, Xing Y, Li D.   +8 more
europepmc   +1 more source

Targeting the ATF4 pathway in cancer therapy

Expert Opinion on Therapeutic Targets, 2012
Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family. ATF4 expression is increased in response to a diverse array of microenvironmental stresses including amino acid depletion, oxidative stress and endoplasmic reticulum (ER) stress that are sensed by upstream eukaryotic translation initiation factor 2α ...
Dean C Singleton, Adrian L Harris
exaly   +4 more sources

Advances in the roles of ATF4 in osteoporosis

Biomedicine and Pharmacotherapy, 2023
Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and enhanced bone fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in cell differentiation, proliferation, apoptosis, redox balance, amino acid uptake, and glycolipid metabolism.
Zhixi Chen, Jianguo Zhou
exaly   +3 more sources

ATF4 regulates lipid metabolism and thermogenesis [PDF]

Cell Research, 2010
Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism.
Chunxia Wang, Shanghai Chen, Feifan Guo   +2 more
exaly   +3 more sources

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TCA cycle off, ATF4 on for metabolic homeostasis

Trends in Biochemical Sciences, 2022
Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox ...
Durga Mahor, Rishikesh Pandey, Vinay Bulusu   +2 more
openaire   +2 more sources

TGFBR3 supports anoikis through suppressing ATF4 signaling

Journal of Cell Science, 2022
ABSTRACT Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor β receptor 3 (TGFBR3) acts as an anoikis mediator through the coordination of activating transcription factor 4 (ATF4).
Yu-Jhen Hsu, Yih-Jia Yin, Kai-Feng Tsai, Cian-Chun Jian, Zi-Wen Liang, Chien-Yu Hsu, Chun-Chao Wang   +6 more
openaire   +2 more sources

Role of ATF4 in skeletal muscle atrophy

Current Opinion in Clinical Nutrition & Metabolic Care, 2017
Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams, Scott M, Ebert, Michael C, Dyle   +2 more
openaire   +2 more sources

Probabilistic models of uORF-mediated ATF4 translation control

Mathematical Biosciences, 2022
ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation of ATF4 increases under conditions of cellular stress while the global translation rate decreases.
Olivia N.J.M. Marasco, Marc R. Roussel, Nehal Thakor   +2 more
openaire   +2 more sources