Results 231 to 240 of about 31,889 (263)

Advances in the roles of ATF4 in osteoporosis

Biomedicine and Pharmacotherapy, 2023
Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and enhanced bone fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in cell differentiation, proliferation, apoptosis, redox balance, amino acid uptake, and glycolipid metabolism.
Jianguo Zhou
exaly   +3 more sources

ATF4 regulates lipid metabolism and thermogenesis [PDF]

Cell Research, 2010
Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism.
Feifan Guo, Shanghai Chen, Chunxia Wang   +2 more
exaly   +3 more sources

Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4 [PDF]

IUBMB Life, 2009
AbstractNuclear protein 1 (NUPR1) was originally identified as p8, a member of the family of HMG‐I/Y transcription factors induced in response to various cellular stressors. However, the signaling pathway underlying NUPR1 induction by cellular stresses remains to be established.
In-Chul Park
exaly   +3 more sources

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TCA cycle off, ATF4 on for metabolic homeostasis

Trends in Biochemical Sciences, 2022
Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox ...
Durga Mahor, Rishikesh Pandey, Vinay Bulusu   +2 more
openaire   +2 more sources

Role of ATF4 in skeletal muscle atrophy

Current Opinion in Clinical Nutrition & Metabolic Care, 2017
Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams, Scott M, Ebert, Michael C, Dyle   +2 more
openaire   +2 more sources

TGFBR3 supports anoikis through suppressing ATF4 signaling

Journal of Cell Science, 2022
ABSTRACT Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor β receptor 3 (TGFBR3) acts as an anoikis mediator through the coordination of activating transcription factor 4 (ATF4).
Yu-Jhen Hsu, Yih-Jia Yin, Kai-Feng Tsai, Cian-Chun Jian, Zi-Wen Liang, Chien-Yu Hsu, Chun-Chao Wang   +6 more
openaire   +2 more sources

Probabilistic models of uORF-mediated ATF4 translation control

Mathematical Biosciences, 2022
ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation of ATF4 increases under conditions of cellular stress while the global translation rate decreases.
Olivia N.J.M. Marasco, Marc R. Roussel, Nehal Thakor   +2 more
openaire   +2 more sources

Phosphorylation-dependent structure of ATF4 peptides derived from a human ATF4 protein, a member of the family of transcription factors

Peptides, 2007
ATF4 plays a crucial role in the cellular response to stress and the F-box protein beta-TrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for ATF4 degradation by the proteasome, binds to ATF4, and controls its stability. Association between the two proteins depends on ATF4 phosphorylation of serine residues 219 and 224 present in ...
Julien, Pons, Nathalie, Evrard-Todeschi, Gildas, Bertho, Josyane, Gharbi-Benarous, Richard, Benarous, Jean-Pierre, Girault   +5 more
openaire   +2 more sources

ATF4 in cellular stress, ferroptosis, and cancer

Archives of Toxicology
Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It orchestrates cellular responses, particularly in the management of endoplasmic reticulum stress, amino acid deprivation, and oxidative challenges.
Hu Tang, Rui Kang, Jiao Liu, Daolin Tang
openaire   +2 more sources

miR-214 targets ATF4 to inhibit bone formation

Nature Medicine, 2012
Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating osteogenic differentiation and bone formation. Thus far, no study has established the pathophysiological role for miRNAs identified in human osteoporotic bone specimens.
Xiaogang, Wang, Baosheng, Guo, Qi, Li, Jiang, Peng, Zhijun, Yang, Aiyuan, Wang, Dong, Li, Zhibo, Hou, Ke, Lv, Guanghan, Kan, Hongqing, Cao, Heng, Wu, Jinping, Song, Xiaohua, Pan, Qiao, Sun, Shukuan, Ling, Yuheng, Li, Mu, Zhu, Pengfei, Zhang, Songlin, Peng, Xiaoqing, Xie, Tao, Tang, An, Hong, Zhaoxiang, Bian, Yanqiang, Bai, Aiping, Lu, Yinghui, Li, Fuchu, He, Ge, Zhang, Yingxian, Li   +29 more
openaire   +2 more sources