Results 231 to 240 of about 32,812 (263)
Targeting the ATF4 pathway in cancer therapy
Expert Opinion on Therapeutic Targets, 2012 Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family. ATF4 expression is increased in response to a diverse array of microenvironmental stresses including amino acid depletion, oxidative stress and endoplasmic reticulum (ER) stress that are sensed by upstream eukaryotic translation initiation factor 2α ...
Dean C Singleton, Adrian Harris
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Advances in the roles of ATF4 in osteoporosis
Biomedicine and Pharmacotherapy, 2023 Osteoporosis (OP) is characterized by reduced bone mass, decreased strength, and enhanced bone fragility fracture risk. Activating transcription factor 4 (ATF4) plays a role in cell differentiation, proliferation, apoptosis, redox balance, amino acid uptake, and glycolipid metabolism.
Zhixi Chen, Jianguo Zhou, Xunlu Xie
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ATF4 regulates lipid metabolism and thermogenesis [PDF]
Cell Research, 2010 Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism.
Feifan Guo, Shanghai Chen, Chunxia Wang
exaly +3 more sources
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TCA cycle off, ATF4 on for metabolic homeostasis
Trends in Biochemical Sciences, 2022Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox ...
Durga Mahor +2 more
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Role of ATF4 in skeletal muscle atrophy
Current Opinion in Clinical Nutrition & Metabolic Care, 2017Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams +2 more
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ATF4 in cellular stress, ferroptosis, and cancer
Archives of ToxicologyActivating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced transcription factor. It orchestrates cellular responses, particularly in the management of endoplasmic reticulum stress, amino acid deprivation, and oxidative challenges.
Daolin Tang, Jiao Liu, Hu Tang
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TGFBR3 supports anoikis through suppressing ATF4 signaling
Journal of Cell Science, 2022ABSTRACT Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor β receptor 3 (TGFBR3) acts as an anoikis mediator through the coordination of activating transcription factor 4 (ATF4).
Yu-Jhen Hsu +6 more
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Probabilistic models of uORF-mediated ATF4 translation control
Mathematical Biosciences, 2022ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation of ATF4 increases under conditions of cellular stress while the global translation rate decreases.
Olivia N.J.M. Marasco +2 more
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Peptides, 2007
ATF4 plays a crucial role in the cellular response to stress and the F-box protein beta-TrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for ATF4 degradation by the proteasome, binds to ATF4, and controls its stability. Association between the two proteins depends on ATF4 phosphorylation of serine residues 219 and 224 present in ...
Julien, Pons +5 more
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ATF4 plays a crucial role in the cellular response to stress and the F-box protein beta-TrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for ATF4 degradation by the proteasome, binds to ATF4, and controls its stability. Association between the two proteins depends on ATF4 phosphorylation of serine residues 219 and 224 present in ...
Julien, Pons +5 more
openaire +2 more sources