Results 241 to 250 of about 31,889 (263)
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ATF4, Hypoxia and Treatment Resistance in Cancer
2019Oxygen deprivation (hypoxia) is a common feature of tumors that is associated with treatment resistance and poor patient survival. Hypoxia perturbs the oxidative environment within the endoplasmic reticulum (EnR), limiting protein folding capacity.
Dean C. Singleton, Adrian L. Harris
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ATF4: a novel regulator of cell growth
Blood, 2002Activating transcription factor-4 (ATF4) is a member of the ATF/CREB subfamily of basic region-leucine zipper proteins. ATF4 forms homodimers or heterodimers by interacting with itself or other proteins through its leucine zipper motif. Potential partners of ATF4 include members of the AP-1 and C/
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ATF4: a Novel Potential Therapeutic Target for Alzheimer’s Disease
Molecular Neurobiology, 2014Activating transcription factor 4 (ATF4) belongs to the activating transcription factor family and its expression is increased upon the stimulation of a diverse array of microenvironmental stresses. ATF4 plays a major role in the development, metabolism, and memory formation.
Na, Wei, Ling-Qiang, Zhu, Dan, Liu
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Cellular Signalling
To investigate the role and mechanism of miR-383-3p in sepsis-induced myocardial dysfunction (SIMD), with a focus on ferroptosis.Plasma miR-383-3p levels were measured in sepsis patients with/without SIMD and healthy controls. In vitro, LPS-treated rat cardiomyocytes (H9C2) were transfected with miR-383-3p mimics or inhibitors.
Yazhou, Li +3 more
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To investigate the role and mechanism of miR-383-3p in sepsis-induced myocardial dysfunction (SIMD), with a focus on ferroptosis.Plasma miR-383-3p levels were measured in sepsis patients with/without SIMD and healthy controls. In vitro, LPS-treated rat cardiomyocytes (H9C2) were transfected with miR-383-3p mimics or inhibitors.
Yazhou, Li +3 more
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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
Journal of Nutrition, 2022Adrian Vella +2 more
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ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis
Journal of Hepatology, 2023Michael Karin +2 more
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YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis
EMBO Molecular Medicine, 2021Michael T Dill +2 more
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Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells
Trends in Endocrinology and Metabolism, 2017Frank N van Leeuwen +2 more
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