Results 241 to 250 of about 30,346 (252)

Phosphorylation-dependent structure of ATF4 peptides derived from a human ATF4 protein, a member of the family of transcription factors

Peptides, 2007
ATF4 plays a crucial role in the cellular response to stress and the F-box protein beta-TrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for ATF4 degradation by the proteasome, binds to ATF4, and controls its stability. Association between the two proteins depends on ATF4 phosphorylation of serine residues 219 and 224 present in ...
Julien, Pons, Nathalie, Evrard-Todeschi, Gildas, Bertho, Josyane, Gharbi-Benarous, Richard, Benarous, Jean-Pierre, Girault   +5 more
openaire   +2 more sources

miR-214 targets ATF4 to inhibit bone formation

Nature Medicine, 2012
Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating osteogenic differentiation and bone formation. Thus far, no study has established the pathophysiological role for miRNAs identified in human osteoporotic bone specimens.
Xiaogang, Wang, Baosheng, Guo, Qi, Li, Jiang, Peng, Zhijun, Yang, Aiyuan, Wang, Dong, Li, Zhibo, Hou, Ke, Lv, Guanghan, Kan, Hongqing, Cao, Heng, Wu, Jinping, Song, Xiaohua, Pan, Qiao, Sun, Shukuan, Ling, Yuheng, Li, Mu, Zhu, Pengfei, Zhang, Songlin, Peng, Xiaoqing, Xie, Tao, Tang, An, Hong, Zhaoxiang, Bian, Yanqiang, Bai, Aiping, Lu, Yinghui, Li, Fuchu, He, Ge, Zhang, Yingxian, Li   +29 more
openaire   +2 more sources

ATF4, Hypoxia and Treatment Resistance in Cancer

2019
Oxygen deprivation (hypoxia) is a common feature of tumors that is associated with treatment resistance and poor patient survival. Hypoxia perturbs the oxidative environment within the endoplasmic reticulum (EnR), limiting protein folding capacity.
Dean C. Singleton, Adrian L. Harris
openaire   +1 more source

ATF4: a Novel Potential Therapeutic Target for Alzheimer’s Disease

Molecular Neurobiology, 2014
Activating transcription factor 4 (ATF4) belongs to the activating transcription factor family and its expression is increased upon the stimulation of a diverse array of microenvironmental stresses. ATF4 plays a major role in the development, metabolism, and memory formation.
Na, Wei, Ling-Qiang, Zhu, Dan, Liu
openaire   +2 more sources

ATF4: a novel regulator of cell growth

Blood, 2002
Activating transcription factor-4 (ATF4) is a member of the ATF/CREB subfamily of basic region-leucine zipper proteins. ATF4 forms homodimers or heterodimers by interacting with itself or other proteins through its leucine zipper motif. Potential partners of ATF4 include members of the AP-1 and C/
openaire   +1 more source

Atf4

AfCS-Nature Molecule Pages, 2011
Kurosh Ameri, Adrian Harris, Dean Singleton   +2 more
openaire   +1 more source

MiR-383-3p attenuates sepsis-induced myocardial ferroptosis by targeting ATF4 and inhibiting the ATF4-CHOP-CHAC1 signaling axis

Cellular Signalling
To investigate the role and mechanism of miR-383-3p in sepsis-induced myocardial dysfunction (SIMD), with a focus on ferroptosis.Plasma miR-383-3p levels were measured in sepsis patients with/without SIMD and healthy controls. In vitro, LPS-treated rat cardiomyocytes (H9C2) were transfected with miR-383-3p mimics or inhibitors.
Yazhou, Li, Yan, Shao, Jie, Su, Shimin, Dong   +3 more
openaire   +2 more sources

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

Journal of Nutrition, 2022
Scott M Ebert, Blake B Rasmussen, Lars Larsson   +2 more
exaly  

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

Cancer Cell, 2018
Crystal S Conn, Anna I Scott, Anthony Le   +2 more
exaly  

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

Trends in Endocrinology and Metabolism, 2017
Inge M N Wortel, Laurens T Van Der Meer, Michael S Kilberg   +2 more
exaly