Results 111 to 120 of about 28,738 (248)

ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer

Molecular Oncology, 2018
Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to ...
Chun‐Yu Liu, Chia‐Chi Hsu, Tzu‐Ting Huang, Chia‐Han Lee, Ji‐Lin Chen, Shung‐Haur Yang, Jeng‐Kai Jiang, Wei‐Shone Chen, Kuan‐Der Lee, Hao‐Wei Teng   +9 more
doaj   +1 more source

Endothelial cells, endoplasmic reticulum stress and oxysterols [PDF]

, 2017
Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis.
Canonico, B., Cesarini, E., Crinelli, R., Di Sario, G., Guidi, L., Iuliano, Luigi, Luchetti, F, Magnani, M., Papa, S., Zamai, L., Zerbinati, C.   +10 more
core   +3 more sources

Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression

Oral Diseases, EarlyView.
ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du, Zi Yang, Yang Yang, Chunmei Zhang, Hideaki Kagami, Xianqi Li, Liang Hu, Junji Xu, Jian Zhou   +8 more
wiley   +1 more source

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

iScience, 2020
Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches.
Huan Yang, Marije Niemeijer, Bob van de Water, Joost B. Beltman   +3 more
doaj   +1 more source

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response [PDF]

, 2012
Poly(ADP-ribose) polymerases (PARPs; also known as ADP-ribosyl transferase D proteins) modify acceptor proteins with ADP-ribose modifications of varying length (reviewed in refs 1, 2, 3). PARPs regulate key stress response pathways, including DNA damage
A Bertolotti, AK Leung, BD Hamman, C Sidrauski, D Ron, E Pedrazzini, H Harding, H Kleine, H Lorenz, HP Harding, I Kim, J Ménissier-de Murcia, JD Malhotra, L Zheng, M Calfon, M Malanga, M Schuldiner, Miri Jwa, MO Hottiger, N Borgese, P Chang, P Walter, P Whitley, Paul Chang, PO Hassa, R Sriburi, S Di Paola, SB Stephens, V Schreiber, Y Kimata   +29 more
core   +1 more source

MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway

Molecular Medicine
Rheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated.
Guozhi Yan, Rongrong Song, Jieyu Zhang, Zhihao Li, Zhantao Lu, Zijian Liu, Xiaokang Zeng, Jie Yao   +7 more
doaj   +1 more source

A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability

Journal of Biomedical Science, 2018
Background Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) is proteolytically cleaved to ...
Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan, Jim-Tong Horng   +3 more
doaj   +1 more source

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. [PDF]

, 2013
Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan.
Andreyev, Alexander Y, Chen, Yi-Fan, Divakaruni, Ajit S, Dixon, Jack E, Karisch, Robert, Murphy, Anne N, Neel, Benjamin G, Perkins, Guy, Simon, Melvin I, Tsai, Ting-Fen, van der Geer, Peter, Wall, Estelle A, Wiley, Sandra E   +12 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

A pilot study on gene expression of endoplasmic reticulum unfolded protein response in chronic kidney disease

Biochemistry and Biophysics Reports, 2020
Background: Chronic kidney disease (CKD) is a worldwide public health problem due to its increasing prevalence worldwide. Endoplasmic reticulum (ER) stress has been shown to play a role in the pathogenesis of various renal diseases in humans. It leads to
Rasha G. Mostafa, Abd El-Aleem Hassan Abd El-Aleem, Eman Abdella Mahmoud Fouda, Fardous Rabea Ahmed Taha, Khaled Mohamed Amin Elzorkany   +4 more
doaj   +1 more source