Results 121 to 130 of about 29,072 (277)

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review

Phytotherapy Research, EarlyView.
Phytoestrogen signal pathways targeted in ovarian cancer. ABSTRACT Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer‐related deaths in Western societies.
Ozgur Kutuk, Ayse Kaplan
wiley   +1 more source

Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in dutch Caucasians [PDF]

, 2007
Context: Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians ...
Ayoubi, Torik A., Boer, Jolanda M. A., de Bruin, Tjerk W. A., Feskens, Edith J. M., Hofker, Martin H., Meex, Steven J. R., Schalkwijk, Casper G., Stehouwer, Coen D. A., van der Kallen, Carla J. H., van Greevenbroek, Marleen M. J., van Vliet-Ostaptchouk, Jana V., Vermeulen, Vicky M. M. -J., Vlietinck, Robert   +12 more
core   +2 more sources

Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation

Theranostics, 2020
Rationale: Myocardial vulnerability to ischemia/reperfusion (I/R) injury is strictly regulated by energy substrate metabolism. Branched chain amino acids (BCAA), consisting of valine, leucine and isoleucine, are a group of essential amino acids that are ...
Yueyang Li, Zhenyu Xiong, Wenjun Yan, E. Gao, He-xiang Cheng, Guiling Wu, Yi Liu, Ling Zhang, Congye Li, Shan Wang, M. Fan, Huishou Zhao, Fuyang Zhang, L. Tao   +13 more
semanticscholar   +1 more source

Impact of ATF6 deletion on the embryonic brain development

iScience
Although the unfolded protein response (UPR) is activated during brain development, its roles remain unclear. Here, we report that deletion of activating transcription factor 6 (ATF6), consisting of ATF6α and ATF6β, in the developing brain caused microcephaly and neonatal death in mice.
Loc Dinh Nguyen, Ly Huong Nguyen, Dat Xuan Dao, Tsuyoshi Hattori, Mika Takarada-Iemata, Hiroshi Ishii, Takashi Tamatani, Hiroshi Kawasaki, Yohei Shinmyo, Kenta Onoue, Shigenobu Yonemura, Jun Zhang, Masato Miyake, Seiichi Oyadomari, Kazutoshi Mori, Osamu Hori   +15 more
openaire   +2 more sources

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]

, 2020
IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear, Adrienne W. Paton, Amin-Wetzel, Bertolotti, Bertolotti, Calfon, Chang, Delphine De Sutter, Eva Cloots, Feldman, Haber, Heidi De Luca, Hetz, Hollien, Hollien, Imagawa, Iwawaki, Iwawaki, James C. Paton, Jay R. Thiagarajah, Karagöz, Lee, Li, Lisbona, Lu, Mariska S. Simpson, Markus A. Seeliger, Martino, Mi, Michael J. Grey, Miyoshi, Nicole LeDuc, Paton, Paton, Phi Luong, Prischi, Sepulveda, Shemorry, Singh, Sophie Janssens, Sundaram, Sven Eyckerman, Tam, Tirasophon, Tirasophon, Tschurtschenthaler, Tsuru, Tsuru, Walter, Wang, Wang, Wayne I. Lencer, Wiseman, Yevgeniy V. Serebrenik, Yoshida   +54 more
core   +1 more source

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1 [PDF]

Blood, 2019
AbstractTissue-type plasminogen activator (tPA) is a major mediator of fibrinolysis and, thereby, prevents excessive coagulation without compromising hemostasis. Studies on tPA regulation have focused on its acute local release by vascular cells in response to injury or other stimuli.
Ze Zheng, Lalitha Nayak, Wei Wang, Arif Yurdagul, Xiaobo Wang, Bishuang Cai, Stephanie Lapping, Lale Ozcan, Rajasekhar Ramakrishnan, Richard G. Pestell, Mukesh K. Jain, Ira Tabas   +11 more
openaire   +4 more sources

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability

Journal of Biomedical Science, 2018
Background Due to limited coding capacity of viral genome, enterovirus A71 (EV-A71) co-opts host nuclear proteins for its replication. Upon ER stress, the ER-localized 90 kDa activating transcription factor 6 (p90ATF6) is proteolytically cleaved to ...
Jia-Rong Jheng, Kean-Seng Lau, Yueh-Wen Lan, Jim-Tong Horng   +3 more
doaj   +1 more source