Results 141 to 150 of about 29,072 (277)

IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy [PDF]

, 2018
Sensors of endoplasmic reticulum (ER) stress function in a co-ordinated manner. In the present study we investigated the relationship between IRE1α and PERK pathways and survival of ER stressed U937 cells and BC3 cells. To this end, we investigated the
Alfano, Vincenzo, Carbotta, Sabino, Di Renzo, Livia, Ferretti, Elisabetta, Storniolo, Antonello   +4 more
core   +2 more sources

MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway

Molecular Medicine
Rheumatoid arthritis (RA) is a common autoimmune disease that can lead to irreversible joint damage when it occurs, but its pathogenesis has not yet been elucidated.
Guozhi Yan, Rongrong Song, Jieyu Zhang, Zhihao Li, Zhantao Lu, Zijian Liu, Xiaokang Zeng, Jie Yao   +7 more
doaj   +1 more source

Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract Diabetic retinopathy (DR) and Alzheimer's disease (AD) are progressive neurodegenerative disorders affecting the eye and the brain, respectively. Despite targeting different organs, they share common molecular mechanisms. A central process connecting these conditions is the unfolded protein response (UPR), which maintains protein homeostasis ...
Adrián G. Palacios, Sarah X. Zhang, Mónica L. Acosta   +2 more
wiley   +1 more source

Liver X Receptor Activation Alleviates Hepatic Ischemia‐Reperfusion Injury in Diabetes by Inhibiting NF‐κB–NLRP3 Activation

Immunity, Inflammation and Disease, Volume 13, Issue 8, August 2025.
ABSTRACT Introduction Hyperglycemia has been reported to be a crucial factor that aggravates liver ischemia‐reperfusion injury (IRI). Macrophage–mediated inflammatory injury is vital to liver IRI. A positive effect of Liver X receptor (LXR) on diabetes has been proven; however, the function and mechanism of LXR in diabetic liver IRI remain unclear ...
Chuanwei Jiang, Wenzhou Ding, Yuanchang Hu, Chao Yang   +3 more
wiley   +1 more source

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Nature Communications, 2019
Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases. However, this approach has not been employed in vivo. Here we show, using a mouse
Erik A. Blackwood, Khalid M. Azizi, D. Thuerauf, Ryan J. Paxman, L. Plate, J. Kelly, R. Wiseman, C. Glembotski   +7 more
semanticscholar   +1 more source

The Effects of IRE1, ATF6, and PERK Signaling on adRP-Linked Rhodopsins [PDF]

, 2014
Many mutations in rhodopsin gene linked to retinitis pigmentosa (RP) cause rhodopsin misfolding. Rod photoreceptor cells expressing misfolded rhodopsin eventually die. Identifying mechanisms to prevent rhodopsin misfolding or to remove irreparably misfolded rhodopsin could provide new therapeutic strategies.
Jerry Chiang, Wei-Chieh, Lin, Jonathan H
openaire   +5 more sources

Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study

International Journal of Gynecology &Obstetrics, Volume 170, Issue 2, Page 774-782, August 2025.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya, Eissa Almaghrebi, Fatma Akat, Eda Nur Hepbildi, Esra Kosucu, Muslu Kazım Körez, Husamettin Vatansev   +6 more
wiley   +1 more source

E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. [PDF]

, 2019
Objective: Since the introduction in 2004, global usage of e-cigarettes (ECs) has risen exponentially. However, the risks of ECs on oral health are uncertain.
Chen, Wei, Cui, Li, Elzakra, Naseim, Hu, Shen, Ji, Eoon Hye, Lee, Eon S, Messadi, Diana, Sun, Bingbing, Xia, Tian, Zhu, Yifang   +9 more
core  

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors [PDF]

, 2016
The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds and
Callegari, Eduardo A., Chien, Jeremy, Drappeau, Donis D., Eyster, Kathleen M., Gamarra Luques, Carlos Diego, Goyeneche, Alicia A., Hapon, María Belén, Knapp, Jennifer R., Pan, Bo, Srinivasan, Rekha, Telleria, Carlos Marcelo, Terpstra, Erin J., Wang, Xuejun, Zhang, Lei   +13 more
core   +1 more source

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

Cell Reports, 2016
Defective insulin signaling in hepatocytes is a key factor in type 2 diabetes. In obesity, activation of calcium/calmodulin-dependent protein kinase II (CaMKII) in hepatocytes suppresses ATF6, which triggers a PERK-ATF4-TRB3 pathway that disrupts insulin
Lale Ozcan, Devram S. Ghorpade, Ze Zheng, Jane Cristina de Souza, Ke Chen, Marc Bessler, Melissa Bagloo, Beth Schrope, Richard Pestell, Ira Tabas   +9 more
doaj   +1 more source