Results 151 to 160 of about 21,147 (240)

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

, 2002
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecular chaperones. Upon ER stress, ATF6 translocates from the ER to the Golgi where it is processed to its active form. We
Prywes, Ron, Chen, Xi, Shen, Jingshi, Hendershot, Linda   +3 more
core   +1 more source

Imperatorin ameliorates myocardial ischemia‐reperfusion injury by inhibiting endoplasmic reticulum stress‐mediated apoptosis via the PI3K/AKT/Nrf2 pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
By activating the PI3K/AKT/Nrf2 pathway, imperatorin can reduce endoplasmic reticulum stress and its mediated apoptosis in cardiomyocytes, improve the pathological changes of myocardial tissue, and thus improve myocardial ischemia/reperfusion injury.
Mingjun Han, Fan Yu, Huanhuan Li
wiley   +1 more source

The effect of ATF6 deletion on ALS pathology

, 2017
筋萎縮性側索硬化症(ALS)における小胞体ストレス応答(UPR)の重要性を明らかにする為、UPRのセンサーATF6αを欠損したATF6(-/-)マウスとALSマウスを交配し、表現型の変化を観察した。その結果、ATF6(-/-)×ALSマウスではALSマウスに比べてALS発症時期が有意に早まったが、生存期間については両者で差は認められなかった。更に、前者では後者に比べてより早期から運動神経線維に変異蛋白質の集積を認める一方、ATF6欠損によりミクログリアを介した脳内炎症は減弱することが明らかになった ...
233, 堀, 修, 60303947
core   +1 more source

STING Modulating ER‐Phagy in the Prelimbic Cortex Neurons Contributed to Neuropathic Pain and Emotional Comorbidity

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SNL induced ER‐phagy impairment and ER stress increase in the PrL neuron via STING and the STING pathway. Our data indicated that enhancing ER‐phagy in PrL neurons might provide analgesic and antidepressant effects through STING and its pathways in SNL mice. ABSTRACT Background Our previous data suggested that autophagy is crucial for neuropathic pain.
Yongda Liu, Xu Yang, Shihui Kuai, Xi Chen, Zhibin Wang, Zhongsheng Yang, Xiaochuan Guo, Xin He, Ping Zhao   +8 more
wiley   +1 more source

Edible Fungus Compound Cordycepin Protects Against Acetaminophen‐Induced Liver Injury

Journal of Clinical Laboratory Analysis, Volume 40, Issue 11, June 2026.
This study demonstrates that pretreatment with cordycepin (COR) effectively protects against acetaminophen (APAP)‐induced acute liver injury in mice. COR mitigates liver damage by exerting strong antioxidant, anti‐inflammatory, and anti‐apoptotic effects through the modulation of ER proteostasis, HIF‐1, and PPAR signaling networks.
Chunjin Fu, Shuyu Li, Shengnan Shen, Chengchao Xu, Jingjing Liao, Na Lin   +5 more
wiley   +1 more source

Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed, Yilin Wang, Yangping Li, Guoku Hu, Jingjing Yang, Bing Yao, Andrew Escayg   +6 more
wiley   +1 more source

ATF6 wt Allele [PDF]

, 2020
openaire   +1 more source

The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma

MedComm, Volume 7, Issue 6, June 2026.
To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr, Carolin Schneider, Ningjun Duan, Hazal Köse, Anantharamanan Rajamani, Xueyang He, Jonas Buchloh, Christian Hintze, Atharva Naik, Daniel Goeke, Nicole Rjasanow, Lukas Krauß, Alexandra Nguyen, Sebastian A. Widholz, Christian Schneeweis, Riccardo Trozzo, Felix Orben, Sebastian Mueller, Rupert Öllinger, Juan J Montero, Michael Dudek, Percy Knolle, Bo Kong, Volker Ellenrieder, Constanza Tapia Contreras, Elisabeth Hessmann, Marian Grade, Michael Ghadimi, Christian J. Braun, Roland Rad, Maximillian Reichert, Ulrich Keller, Roland M. Schmid, Paul L. Boutz, Dieter Saur, Matthias Wirth, Oliver H. Krämer, Günter Schneider   +37 more
wiley   +1 more source

Biophysical assessment of the molecular mechanisms of Tau aggregation and its role in Alzheimer's disease

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is characterized by the intracellular aggregation of the microtubule‐associated protein Tau. While the presence of large, insoluble neurofibrillary tangles has long been the primary focus of this research, a paradigm shift in the field now highlights smaller, soluble oligomers as the more neurotoxic Tau species leading
Joshua T. Skrehot, Dmitry Kurouski
wiley   +1 more source

Activation of TRIM37 by ATF6 and degradation of ACSL4: inhibiting ferroptosis and propelling cervical cancer progression

Hereditas
Background Cervical cancer (CC), a prevalent gynecological malignancy, shows high global incidence and mortality. Tripartite motif-containing 37 (TRIM37), a significant ubiquitinating enzyme, is overexpressed in CC, fueling its progression, but its role ...
Yang Wang, Li Xie, Shiying Jin, YouXiang Hou, Yina Wang   +4 more
doaj   +1 more source