Results 231 to 240 of about 28,738 (248)

ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice

Andrologia, 2021
Activating transcription factor 6 (ATF6), also known as ACHM7, ATF6A, encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. It functions as nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is presented in the promoters of genes ...
Ru Yu, Xihua Chen, Xilin Zhu, Bin He, Cong Lu, Ying Liu, Xiangbo Xu, Xiaopan Wu   +7 more
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Transcriptional activation of ATF6 by endoplasmic reticulum stressors

Biochemical and Biophysical Research Communications, 2007
Previous studies have shown that modification of activating transcription factor 6 (ATF6) protein is important for the endoplasmic reticulum (ER) stress response; ER stressors stimulate the degradation of ATF6 by Site-1 protease (S1P) and Site-2 protease (S2P) into p50-ATF6, which acts as a transcription factor.
Takushi, Namba, Tomoaki, Ishihara, Ken-ichiro, Tanaka, Tatsuya, Hoshino, Tohru, Mizushima   +4 more
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A primitive role for ATF6

Science, 2018
Development The unfolded protein response (UPR) preserves endoplasmic reticulum (ER) homeostasis in mature cells. However, inactivating mutations in the UPR-associated transcription factor ATF6 cause congenital vision defects, suggesting a developmental role for ATF6 as well.
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ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes

Toxicological Sciences, 2023
Abstract In this study, we examined the mechanisms of cadmium exposure-induced endoplasmic reticulum (ER) stress response and apoptosis in spermatocytes. Responses to cadmium toxicity were investigated using spermatocytes overexpressing p50ATF6, ATF4, and spliced XBP1s, belonging to the 3 unfolded protein response pathways. The ER stress
Sung Woo Lee, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong-Seok Lee   +5 more
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ER stress signaling by regulated proteolysis of ATF6

Methods, 2005
ATF6 is an endoplasmic reticulum (ER) membrane-anchored transcription factor activated by intramembrane proteolysis in the ER stress response. Upon ER stress, ATF6 is transported from the ER to the Golgi to be processed by site-1 and site-2 proteases. The trafficking is controlled by the ER chaperone BiP/GRP78.
Jingshi, Shen, Ron, Prywes
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“ATF6 Promotes Early Stem Cell Development”

The FASEB Journal, 2016
Stem cells have scant and simplified organelles. The endoplasmic reticulum (ER) is the organelle of protein assembly, protein folding and protein maturation. The Unfolded Protein Response (UPR) is the regulatory mechanism that supports ER function and homeostasis.
Heike Kroeger, Wei‐Chieh Chiang, R Luke Wiseman, Jonathan H. Lin   +3 more
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A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level

International Journal of Cancer, 2013
Accumulated evidences indicate that single nucleotide polymorphisms (SNP) are associated with risk of hepatocellular carcinoma (HCC). Activating transcription factor 6 (ATF6) is an important modulator of the unfolded protein response (UPR), which is regarded to be involved in carcinogenesis.
Xiaopan, Wu, Zhenhui, Xin, Wei, Zhang, Sujun, Zheng, Jia, Wu, Kangmei, Chen, Huifen, Wang, Xilin, Zhu, Zhuo, Li, Zhongping, Duan, Hui, Li, Ying, Liu   +11 more
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ATF6-Mediated Signaling Contributes to PARP Inhibitor Resistance in Ovarian Cancer

Molecular Cancer Research, 2022
Abstract High-grade serous ovarian cancer (HGSOC) is the deadliest ovarian cancer histotype due in-part to the lack of therapeutic options for chemotherapy-resistant disease. PARP inhibitors (PARPi) represent a targeted treatment.
Alexandra McMellen, Tomomi M. Yamamoto, Lubna Qamar, Brooke E. Sanders, Lily L. Nguyen, Daniela Ortiz Chavez, Jaidev Bapat, Amber Berning, Miriam D. Post, Joshua Johnson, Kian Behbakht, Elmar Nurmemmedov, Edward B. Chuong, Benjamin G. Bitler   +13 more
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ATF6 polymorphisms and protective effect in diabetic retinopathy

Meta Gene, 2018
Abstract Activating transcription factor 6 (ATF6) has been observed to be a strong contributor in pathology of diabetes via its angiogenesis and apoptosis role, therefore in the present study we investigated the role of ATF6 polymorphisms (rs1058405; rs11579627; rs13401) in diabetic retinopathy (DR) susceptibility in Pakistani type 2 diabetes ...
Mina Tayyab, Sundus Ijaz Maqsood, Aisha Azam, Irfan Muslim, Zehra Agha, Sobia Shafique, Waqas Ahmed, Muhammad Khizar Niazi, Mazhar Ishaq, Nadia Khalida Waheed, Maleeha Azam, Raheel Qamar   +11 more
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