Results 211 to 220 of about 28,246 (239)
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Science, 2018
Development The unfolded protein response (UPR) preserves endoplasmic reticulum (ER) homeostasis in mature cells. However, inactivating mutations in the UPR-associated transcription factor ATF6 cause congenital vision defects, suggesting a developmental role for ATF6 as well.
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Development The unfolded protein response (UPR) preserves endoplasmic reticulum (ER) homeostasis in mature cells. However, inactivating mutations in the UPR-associated transcription factor ATF6 cause congenital vision defects, suggesting a developmental role for ATF6 as well.
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ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes
Toxicological Sciences, 2023Abstract In this study, we examined the mechanisms of cadmium exposure-induced endoplasmic reticulum (ER) stress response and apoptosis in spermatocytes. Responses to cadmium toxicity were investigated using spermatocytes overexpressing p50ATF6, ATF4, and spliced XBP1s, belonging to the 3 unfolded protein response pathways. The ER stress
Sung Woo Lee +5 more
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“ATF6 Promotes Early Stem Cell Development”
The FASEB Journal, 2016Stem cells have scant and simplified organelles. The endoplasmic reticulum (ER) is the organelle of protein assembly, protein folding and protein maturation. The Unfolded Protein Response (UPR) is the regulatory mechanism that supports ER function and homeostasis.
Heike Kroeger +3 more
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International Journal of Cancer, 2013
Accumulated evidences indicate that single nucleotide polymorphisms (SNP) are associated with risk of hepatocellular carcinoma (HCC). Activating transcription factor 6 (ATF6) is an important modulator of the unfolded protein response (UPR), which is regarded to be involved in carcinogenesis.
Xiaopan, Wu +11 more
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Accumulated evidences indicate that single nucleotide polymorphisms (SNP) are associated with risk of hepatocellular carcinoma (HCC). Activating transcription factor 6 (ATF6) is an important modulator of the unfolded protein response (UPR), which is regarded to be involved in carcinogenesis.
Xiaopan, Wu +11 more
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ATF6-Mediated Signaling Contributes to PARP Inhibitor Resistance in Ovarian Cancer
Molecular Cancer Research, 2022Abstract High-grade serous ovarian cancer (HGSOC) is the deadliest ovarian cancer histotype due in-part to the lack of therapeutic options for chemotherapy-resistant disease. PARP inhibitors (PARPi) represent a targeted treatment.
Alexandra McMellen +13 more
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ATF6 polymorphisms and protective effect in diabetic retinopathy
Meta Gene, 2018Abstract Activating transcription factor 6 (ATF6) has been observed to be a strong contributor in pathology of diabetes via its angiogenesis and apoptosis role, therefore in the present study we investigated the role of ATF6 polymorphisms (rs1058405; rs11579627; rs13401) in diabetic retinopathy (DR) susceptibility in Pakistani type 2 diabetes ...
Mina Tayyab +11 more
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ATF6 protects against protein misfolding during cardiac hypertrophy
Journal of Molecular and Cellular CardiologyCardiomyocytes activate the unfolded protein response (UPR) transcription factor ATF6 during pressure overload-induced hypertrophic growth. The UPR is thought to increase ER protein folding capacity and maintain proteostasis. ATF6 deficiency during pressure overload leads to heart failure, suggesting that ATF6 protects against myocardial dysfunction by
Christoph, Hofmann +14 more
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ATF6 activation in breast cancer.
We studied mobilization of nuclear factors in human breast cancer.openaire +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022
Ojore Oka +2 more
exaly
Ojore Oka +2 more
exaly