Results 211 to 220 of about 21,147 (240)

Transcriptional activation of ATF6 by endoplasmic reticulum stressors

Biochemical and Biophysical Research Communications, 2007
Previous studies have shown that modification of activating transcription factor 6 (ATF6) protein is important for the endoplasmic reticulum (ER) stress response; ER stressors stimulate the degradation of ATF6 by Site-1 protease (S1P) and Site-2 protease (S2P) into p50-ATF6, which acts as a transcription factor.
Takushi Namba, Tomoaki Ishihara, Ken-Ichiro Tanaka   +2 more
exaly   +3 more sources

ER stress signaling by regulated proteolysis of ATF6

Methods, 2005
ATF6 is an endoplasmic reticulum (ER) membrane-anchored transcription factor activated by intramembrane proteolysis in the ER stress response. Upon ER stress, ATF6 is transported from the ER to the Golgi to be processed by site-1 and site-2 proteases. The trafficking is controlled by the ER chaperone BiP/GRP78.
Jingshi Shen, Ron Prywes
exaly   +3 more sources

ATF6 is important under both pathological and physiological states in the heart

Journal of Molecular and Cellular Cardiology, 2010
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) evokes the ER stress response, including activating transcription factor 6 (ATF6), a key transcriptional activator to maintain cellular homeostasis. The ER stress has recently been reported to cause various diseases, but the role of ATF6 in the heart remains unknown.
Hidehisa Takahashi, Yosuke Kayama, Sho Okada   +2 more
exaly   +3 more sources

ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice

Andrologia, 2021
Activating transcription factor 6 (ATF6), also known as ACHM7, ATF6A, encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. It functions as nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is presented in the promoters of genes ...
Ru Yu, Xihua Chen, Xilin Zhu, Bin He, Cong Lu, Ying Liu, Xiangbo Xu, Xiaopan Wu   +7 more
openaire   +2 more sources

ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes

Toxicological Sciences, 2023
Abstract In this study, we examined the mechanisms of cadmium exposure-induced endoplasmic reticulum (ER) stress response and apoptosis in spermatocytes. Responses to cadmium toxicity were investigated using spermatocytes overexpressing p50ATF6, ATF4, and spliced XBP1s, belonging to the 3 unfolded protein response pathways. The ER stress
Sung Woo Lee, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong-Seok Lee   +5 more
openaire   +2 more sources

Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response

Journal of Molecular and Cellular Cardiology, 2012
A nodal regulator of endoplasmic reticulum stress is the transcription factor, ATF6, which is activated by ischemia and protects the heart from ischemic damage, in vivo.
Donna J Thuerauf, Christopher C Glembotski   +1 more
exaly   +1 more source

A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level

International Journal of Cancer, 2013
Accumulated evidences indicate that single nucleotide polymorphisms (SNP) are associated with risk of hepatocellular carcinoma (HCC). Activating transcription factor 6 (ATF6) is an important modulator of the unfolded protein response (UPR), which is regarded to be involved in carcinogenesis.
Xiaopan, Wu, Zhenhui, Xin, Wei, Zhang, Sujun, Zheng, Jia, Wu, Kangmei, Chen, Huifen, Wang, Xilin, Zhu, Zhuo, Li, Zhongping, Duan, Hui, Li, Ying, Liu   +11 more
openaire   +2 more sources

A primitive role for ATF6

Science, 2018
Development The unfolded protein response (UPR) preserves endoplasmic reticulum (ER) homeostasis in mature cells. However, inactivating mutations in the UPR-associated transcription factor ATF6 cause congenital vision defects, suggesting a developmental role for ATF6 as well.
openaire   +1 more source