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ATF6 polymorphisms and protective effect in diabetic retinopathy
Meta Gene, 2018Abstract Activating transcription factor 6 (ATF6) has been observed to be a strong contributor in pathology of diabetes via its angiogenesis and apoptosis role, therefore in the present study we investigated the role of ATF6 polymorphisms (rs1058405; rs11579627; rs13401) in diabetic retinopathy (DR) susceptibility in Pakistani type 2 diabetes ...
Mina Tayyab +11 more
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“ATF6 Promotes Early Stem Cell Development”
The FASEB Journal, 2016Stem cells have scant and simplified organelles. The endoplasmic reticulum (ER) is the organelle of protein assembly, protein folding and protein maturation. The Unfolded Protein Response (UPR) is the regulatory mechanism that supports ER function and homeostasis.
Heike Kroeger +3 more
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Transcriptomic Profiling of Small Molecule Atf6 Modulators in the Retina
The FASEB JournalABSTRACT The Unfolded Protein Response (UPR) maintains endoplasmic reticulum (ER) homeostasis and is essential for retinal health. Activating Transcription Factor 6 (ATF6) controls a key UPR branch and upregulates genes that mitigate ER stress.
Monica Sophia Diaz‐Aguilar +7 more
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Myogenesis in C2C12 Cells Requires Phosphorylation of ATF6α by p38 MAPK
Biomedicines, 2023Valentina Pagliara +2 more
exaly
Proceedings of the National Academy of Sciences of the United States of America, 2022
Ojore Oka +2 more
exaly
Ojore Oka +2 more
exaly
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb
Circulation Research, 2019Erik A Blackwood +2 more
exaly