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Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome. [PDF]
J Ovarian ResZhang Y, Xie X, Han L.
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Somatostatin analogs in endothelial dysfunction. [PDF]
Am J Physiol Endocrinol MetabBarabutis N.
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ATF6 modulates SREBP2-mediated lipogenesis [PDF]
EMBO Journal, 2004 Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are activated by proteolytic cleavage. The ensuing nuclear translocation of their N-termini (i.e., ATF6(N) and SREBP(N)) activates the respective target genes involved in unfolded protein response and lipogenesis.
Lingfang Zeng, Amy S Lee, Yi Zhu
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ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice
Andrologia, 2021Activating transcription factor 6 (ATF6), also known as ACHM7, ATF6A, encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. It functions as nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is presented in the promoters of genes ...
Ru Yu +7 more
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Proteostasis and Beyond: ATF6 in Ischemic Disease [PDF]
Trends in Molecular Medicine, 2019 Endoplasmic reticulum (ER) stress is a pathological hallmark of numerous ischemic diseases, including stroke and myocardial infarction (MI). In these diseases, ER stress leads to activation of the unfolded protein response (UPR) and subsequent adaptation of cellular physiology in ways that dictate cellular fate following ischemia.
Jessica D Rosarda +2 more
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ATF6 is essential for human cone photoreceptor development
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Inactivating genetic variants in the Unfolded Protein Response (UPR) regulator Activating Transcription Factor 6 (ATF6) result in loss of color vision, which is linked to dysfunctional cone photoreceptors and the development of achromatopsia. The pathomechanims involving the lack of functional
Heike Kroeger +2 more
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ER stress signaling by regulated proteolysis of ATF6
Methods, 2005ATF6 is an endoplasmic reticulum (ER) membrane-anchored transcription factor activated by intramembrane proteolysis in the ER stress response. Upon ER stress, ATF6 is transported from the ER to the Golgi to be processed by site-1 and site-2 proteases. The trafficking is controlled by the ER chaperone BiP/GRP78.
Jingshi Shen
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Transcriptional activation of ATF6 by endoplasmic reticulum stressors
Biochemical and Biophysical Research Communications, 2007Previous studies have shown that modification of activating transcription factor 6 (ATF6) protein is important for the endoplasmic reticulum (ER) stress response; ER stressors stimulate the degradation of ATF6 by Site-1 protease (S1P) and Site-2 protease (S2P) into p50-ATF6, which acts as a transcription factor.
Takushi, Namba +4 more
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