Results 1 to 10 of about 641,945 (161)
Targeting Inflammation in Atherosclerosis — From Experimental Insights to the Clinic
Nature Reviews Drug Discovery, 2021 Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves inflammation from its inception to the emergence of complications.
Peter Libby, Oliver Soehnlein
exaly +2 more sources
T Cell Subsets and Functions in Atherosclerosis
Nature Reviews Cardiology, 2020 Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing and knockout studies in mice, as well as clinical interventional studies ...
Klaus F. Ley +2 more
exaly +2 more sources
Macrophages in Atherosclerosis: A Dynamic Balance
Nature Reviews Immunology, 2013 Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall.
Edward A Fisher +2 more
exaly +2 more sources
Atherosclerosis: Recent Developments
Cell, 2022 Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here we review the current understanding of the molecular, cellular, genetic and environmental contributions to ...
J. Björkegren, A. Lusis
semanticscholar +1 more source
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Signal Transduction and Targeted Therapy, 2022 Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses
Peng Kong +5 more
semanticscholar +1 more source
Wall shear stress and its role in atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of morbidity and mortality in countries around the world. Atherosclerosis combines the interactions of systemic risk factors, haemodynamic factors, and biological ...
Manli Zhou +8 more
semanticscholar +1 more source
Journal of Lipid Research, 1994 A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients.
S Bertolini +9 more
doaj +1 more source
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes
International Journal of Molecular Sciences, 2023 Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to ...
Evgenii Gusev, Alexey Sarapultsev
semanticscholar +1 more source
History of Discovery: Inflammation in Atherosclerosis
Arteriosclerosis, Thrombosis and Vascular Biology, 2012 Experimental work has elucidated molecular and cellular pathways of inflammation that promote atherosclerosis. Unraveling the roles of cytokines as inflammatory messengers provided a mechanism whereby risk factors for atherosclerosis can alter arterial ...
P. Libby
semanticscholar +1 more source
Macrophage polarization and metabolism in atherosclerosis
Cell Death and Disease, 2023 Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke.
Pengbo Hou +15 more
semanticscholar +1 more source