Results 1 to 10 of about 653,040 (342)

GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

Nature Communications, 2023
Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei, Beidi Lan, Tao Zheng, Lin Yang, Xiaoxia Zhang, Lele Cheng, Gulinigaer Tuerhongjiang, Zuyi Yuan, Yue Wu   +8 more
semanticscholar   +1 more source

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Signal Transduction and Targeted Therapy, 2022
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses
Peng Kong, Ziwei Cui, Xiao-Fu Huang, Dandan Zhang, Rui-Juan Guo, Mei Han   +5 more
semanticscholar   +1 more source

Partial duplication of the EGF precursor homology domain of the LDL-receptor protein causing familial hypercholesterolemia (FH-Salerno).

Journal of Lipid Research, 1994
A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients.
S Bertolini, D D Patel, D A Coviello, N Lelli, M Ghisellini, R Tiozzo, P Masturzo, N Elicio, B L Knight, S Calandra   +9 more
doaj   +1 more source

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, 2023
Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to ...
Evgenii Gusev, Alexey Sarapultsev
semanticscholar   +1 more source

Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype.

Journal of Lipid Research, 1993
The apolipoprotein (apo) E isoform is an important determinant of the plasma lipoprotein distribution of apoE and of the metabolism of apoE-containing lipoproteins.
LJ Martin, PW Connelly, D Nancoo, N Wood, ZJ Zhang, G Maguire, E Quinet, AR Tall, YL Marcel, R McPherson   +9 more
doaj   +1 more source

Pathophysiology of Atherosclerosis

International Journal of Molecular Sciences, 2022
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous ...
S. Jebari-Benslaiman, U. Galicia-Garcia, A. Larrea-Sebal, J. R. Olaetxea, I. Alloza, K. Vandenbroeck, A. Benito-Vicente, César Martín   +7 more
semanticscholar   +1 more source

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

Nature Medicine, 2013
Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).
Robert A. Koeth, Zeneng Wang, B. Levison, J. Buffa, Elin Org, Brendan T Sheehy, Earl B. Britt, Xiaoming Fu, Yuping Wu, Lin Li, Jonathan D. Smith, J. DiDonato, Jun Chen, Hongzhe Li, Gary D. Wu, James D. Lewis, M. Warrier, J. M. Brown, Ronald M Krauss, W. H. W. Tang, Frederic D. Bushman, A. Lusis, S. L. Hazen   +22 more
semanticscholar   +1 more source

Apolipoproteins C-III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: the ECTIM study. Etude Cas Témoins sur 'Infarctus du Myocarde

Journal of Lipid Research, 1996
Apolipoprotein (apo) C-III and apoE are components of two major classes of plasma lipoproteins, i.e., apoB- and non-apoB-containing lipoproteins. To analyze the relationship between the distribution of apoC-III and apoE among lipoproteins and coronary ...
G Luc, C Fievet, D Arveiler, A E Evans, J M Bard, F Cambien, J C Fruchart, P Ducimetiere   +7 more
doaj   +1 more source

The Role of Oxidative Stress in Atherosclerosis

Cells, 2022
Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen species (ROS) leads to a state of oxidative stress which is a major risk ...
M. Batty, M. Bennett, E. Yu
semanticscholar   +1 more source

2016 ESC/EAS GUIDELINES FOR THE MANAGEMENT OF DYSLIPIDAEMIAS

Российский кардиологический журнал, 2017
The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)Developed with the special contribution of the European Assocciation for Cardiovascular Prevention & ...
Alberico L. Catapano, Ian Graham, Guy De Backer, Olov Wiklund, John M. Chapman, Heinz Drexel, Arno V. Hoes, Catriona S. Jennings, Ulf Landmesser, Terje R. Pedersen, Željko Reiner, Gabriele Riccardi, Marja-Riitta Taskinen, Lale Tokgozoglu, W. M. Monique Verschuren, Charalambos Vlachopoulos, David A. Wood, Jose Luis Zamorano, Marie-Therese Cooney   +18 more
doaj   +1 more source