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Pathophysiology of Atherosclerosis
International Journal of Molecular Sciences, 2022 Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous ...
S. Jebari-Benslaiman +7 more
semanticscholar +5 more sources
Nature Reviews Disease Primers, 2019 Atherosclerosis, the formation of fibrofatty lesions in the artery wall, causes much morbidity and mortality worldwide, including most myocardial infarctions and many strokes, as well as disabling peripheral artery disease. Development of atherosclerotic lesions probably requires low-density lipoprotein, a particle that carries cholesterol through the ...
P. Libby +7 more
semanticscholar +5 more sources
Lipoproteins and Atherosclerosis [PDF]
Journal of Gerontology, 1951 Author(s): Gofman, John W.; Lindgren, Frank T.; Jones, Hardin B.; Lyon, Thomas P.; Strisower, Beverly.
John W. Gofman +4 more
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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Nature Communications, 2023 Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei +8 more
semanticscholar +1 more source
Analysis of the Effect of Atherosclerosis with the Changes of Hematocrit: A Computational Study on the Hemodynamics of Carotid Artery [PDF]
2020 2nd International Conference on Advanced Information and
Communication Technology (ICAICT) (pp. 336-341). IEEE, 2021 Atherosclerosis is a state wherein plaque (fat, cholesterol, and different substances) develops inside the veins that in the end prompts carotid artery stenosis which is a phase of narrowing in the huge courses situated on either side of the neck that convey blood to the brain, face, and head.
arxiv +1 more source
Atherosclerosis in frailty: Not frailty in atherosclerosis [PDF]
Atherosclerosis, 2017 na
GUARALDI, Giovanni, Raggi, Paolo
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Atherosclerosis and Autoimmunity [PDF]
Mediators of Inflammation, 2018 Abstract Despite a decline in mortality rates in several countries, cardiovascular disease remains the leading cause of death responsible for approximately half of all deaths on the continent. Coronary artery disease and stroke are often the result of acute complications of atherosclerosis (AS) and atherothrombosis.
Francesca Romana Spinelli +4 more
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Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Signal Transduction and Targeted Therapy, 2022 Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses
Peng Kong +5 more
semanticscholar +1 more source
Hemodynamic Bigger Hydrostatic Pressure Instead of Lower Shear Stress Aggravates Atherosclerosis [PDF]
Cardiovascular Research (2021), 2020 The traditional view is that low shear stress of blood flow accelerates atherosclerosis. How does a low shear stress damage the vessel or aggravate atherosclerosis? It is a puzzling question. Furthermore, shear stress of veins is similar to that of Relatively Vulnerable Zones (RVZ) of arteries, while intimal thickening of veins is not obvious as the ...
arxiv +1 more source