Results 1 to 10 of about 1,003,170 (340)

GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

Nature Communications, 2023
Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei, Beidi Lan, Tao Zheng, Lin Yang, Xiaoxia Zhang, Lele Cheng, Gulinigaer Tuerhongjiang, Zuyi Yuan, Yue Wu   +8 more
semanticscholar   +1 more source

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, 2023
Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to ...
Evgenii Gusev, Alexey Sarapultsev
semanticscholar   +1 more source

Wall shear stress and its role in atherosclerosis

Frontiers in Cardiovascular Medicine, 2023
Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of morbidity and mortality in countries around the world. Atherosclerosis combines the interactions of systemic risk factors, haemodynamic factors, and biological ...
Manli Zhou, Yunfeng Yu, Ruiyi Chen, Xingci Liu, Yilei Hu, Zhiyan Ma, Lingwei Gao, W. Jian, Liping Wang   +8 more
semanticscholar   +1 more source

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Signal Transduction and Targeted Therapy, 2022
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses
Peng Kong, Ziwei Cui, Xiao-Fu Huang, Dandan Zhang, Rui-Juan Guo, Mei Han   +5 more
semanticscholar   +1 more source

Pathophysiology of Atherosclerosis

International Journal of Molecular Sciences, 2022
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous ...
S. Jebari-Benslaiman, U. Galicia-Garcia, A. Larrea-Sebal, J. R. Olaetxea, I. Alloza, K. Vandenbroeck, A. Benito-Vicente, César Martín   +7 more
semanticscholar   +1 more source

Partial duplication of the EGF precursor homology domain of the LDL-receptor protein causing familial hypercholesterolemia (FH-Salerno).

Journal of Lipid Research, 1994
A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients.
S Bertolini, D D Patel, D A Coviello, N Lelli, M Ghisellini, R Tiozzo, P Masturzo, N Elicio, B L Knight, S Calandra   +9 more
doaj   +1 more source

MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity [PDF]

, 2014
Background—Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and are important regulators of immuno-inflammatory diseases. However, their role in atherosclerosis remains elusive.
Ait-Oufella, Hafid, Baker, Lauren L., Cambrook, Helen, Finigan, Alison J., Grassia, Gianluca, Hansson, Göran K., Harrison, James E., Hugues, Stéphanie, Ludewig, Burkhard, Maffia, Pasquale, Mallat, Ziad, Masters, Leanne M., Murphy, Deirdre, Reith, Walter, Reizis, Boris, Sabir, Suleman, Sage, Andrew P.   +16 more
core   +2 more sources

Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in men: relationship to apolipoprotein E genotype.

Journal of Lipid Research, 1993
The apolipoprotein (apo) E isoform is an important determinant of the plasma lipoprotein distribution of apoE and of the metabolism of apoE-containing lipoproteins.
LJ Martin, PW Connelly, D Nancoo, N Wood, ZJ Zhang, G Maguire, E Quinet, AR Tall, YL Marcel, R McPherson   +9 more
doaj   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

The Role of Oxidative Stress in Atherosclerosis

Cells, 2022
Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen species (ROS) leads to a state of oxidative stress which is a major risk ...
M. Batty, M. Bennett, E. Yu
semanticscholar   +1 more source