Results 1 to 10 of about 613,802 (161)
Targeting inflammation in atherosclerosis — from experimental insights to the clinic
Nature Reviews Drug Discovery, 2021 Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves inflammation from its inception to the emergence of complications.
Oliver Soehnlein, Peter Libby
exaly +2 more sources
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Nature Reviews Immunology, 2021 Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in preclinical models and emerging evidence in humans have established the crucial roles of the innate and adaptive immune systems in driving atherosclerosis-associated
Payel Roy +2 more
exaly +2 more sources
T cell subsets and functions in atherosclerosis
Nature Reviews Cardiology, 2020 Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing and knockout studies in mice, as well as clinical interventional studies ...
Ryosuke Saigusa +2 more
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Immunity and Inflammation in Atherosclerosis
Circulation Research, 2019 There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical ...
Dennis Wolf, Klaus Ley
exaly +2 more sources
Macrophages in atherosclerosis: a dynamic balance
Nature Reviews Immunology, 2013 Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall.
Kathryn J Moore +2 more
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Atherosclerosis: Recent developments
Cell, 2022 Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to ...
J. Björkegren, A. Lusis
semanticscholar +1 more source
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Signal Transduction and Targeted Therapy, 2022 Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses
Peng Kong +5 more
semanticscholar +1 more source
Macrophage polarization and metabolism in atherosclerosis
Cell Death and Disease, 2023 Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke.
Pengbo Hou +15 more
semanticscholar +1 more source
GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Nature Communications, 2023 Macrophages have been shown to have an important function in atherosclerosis. Here the authors show that, in human atherosclerotic plaques and mouse models, GSDME and pyroptosis promote atherosclerosis and inhibition of these pathways could reduce ...
Yuanyuan Wei +8 more
semanticscholar +1 more source
Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes
International Journal of Molecular Sciences, 2023 Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from a general pathology perspective, particularly with regard to ...
Evgenii Gusev, Alexey Sarapultsev
semanticscholar +1 more source