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Lipoproteins and Atherosclerosis [PDF]
Author(s): Gofman, John W.; Lindgren, Frank T.; Jones, Hardin B.; Lyon, Thomas P.; Strisower, Beverly.
John W. Gofman+4 more
openalex +5 more sources
Pathophysiology of Atherosclerosis
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The
Shifa Jebari-Benslaiman+7 more
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Atherosclerosis in frailty: Not frailty in atherosclerosis [PDF]
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GUARALDI, Giovanni, Raggi, Paolo
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Atherosclerosis and Autoimmunity [PDF]
Abstract Despite a decline in mortality rates in several countries, cardiovascular disease remains the leading cause of death responsible for approximately half of all deaths on the continent. Coronary artery disease and stroke are often the result of acute complications of atherosclerosis (AS) and atherothrombosis.
Francesca Romana Spinelli+4 more
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Atherosclerosis, the formation of fibrofatty lesions in the artery wall, causes much morbidity and mortality worldwide, including most myocardial infarctions and many strokes, as well as disabling peripheral artery disease. Development of atherosclerotic lesions probably requires low-density lipoprotein, a particle that carries cholesterol through the ...
Peter, Libby+7 more
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A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients.
S Bertolini+9 more
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MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity [PDF]
Background—Plasmacytoid dendritic cells (pDCs) bridge innate and adaptive immune responses and are important regulators of immuno-inflammatory diseases. However, their role in atherosclerosis remains elusive.
Ait-Oufella, Hafid+16 more
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Is atherosclerosis a cellular or humoral mediated autoimmune disease?
Y, Sherer, Y, Shoenfeld
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The apolipoprotein (apo) E isoform is an important determinant of the plasma lipoprotein distribution of apoE and of the metabolism of apoE-containing lipoproteins.
LJ Martin+9 more
doaj +1 more source
PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F.+14 more
core +1 more source