Results 31 to 40 of about 39,511 (303)
Oncotarget, 2015 Senescence is a state of stable cell growth arrest that can be triggered by multiple stressors, including oncogene activation [1]. In normal diploid mammalian cells, activation of oncogenes such as oncogenic RAS or BRAF decreases dNTP levels, which leads to replication stress and ultimately senescence [2].
Katherine M, Aird, Rugang, Zhang
openaire +2 more sources
The demand for money, financial innovation, and the welfare cost of inflation: an analysis with household data [PDF]
, 2002 We use microeconomic data on households to estimate the parameters of the demand for currency derived from a generalized Baumol-Tobin model. Our data set contains information on average currency, deposits, and other interest-bearing assets; the number of
Attanasio, O.P., Guiso, L., Jappelli, T.
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Infinitely Complex Machines [PDF]
, 2007 Infinite machines (IMs) can do supertasks. A supertask is an infinite series of operations done in some finite time. Whether or not our universe contains any IMs, they are worthy of study as upper bounds on finite machines.
Steinhart, Eric
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Earth and Space Science, 2022 The National Oceanic and Atmospheric Administration (NOAA) Microwave Integrated Retrieval System (MiRS) algorithm has been producing retrieval products from NOAA‐20 Advanced Technology Microwave Sounder (ATMS) data since shortly after launch in late 2017.
Yong‐Keun Lee +4 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
ATM & Biometric Solutions: A Case Study
International Journal of Experiential Learning & Case Studies, 2019 The paper highlights security features for biometric systems along with application specific to a bank in Pakistan. Further, a comprehensive view of retinal scanning and application within the Internet of Things (IoT) paradigm is discussed.
Muhammad Imran Majid, Yamna Sheikh
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source