Results 21 to 30 of about 55,691 (247)
Atorvastatin-loaded peptide amphiphiles against corneal neovascularization - supplementary material
, 2023 Background: Corneal neovascularization is a sight-threatening disease. It can be treated using antiangiogenic and anti-inflammatory compounds. Therefore, atorvastatin (ATV) constitutes a suitable candidate to be administered topically. To attain suitable
Elena Sanchez-Lopez (16870506) +2 more
core +1 more source
The Korean Journal of Gastroenterology, 2021 Backgrounds/Aims: PPARγ, farnesoid X receptor (FXR) and CYP7A1 are associated with solubility of bile. This study was performed to understand a mechanism and interactions of statin-induced PPARγ, PGC-1α and HNF-4α related to the statin-induced activation
Jin Lee +7 more
doaj +1 more source
Medical Laboratory Journal, 2022 Background and objectives: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by the accumulation of large amounts of fat in the hepatocytes.
Zahra Eslami +8 more
doaj
Pharmacokinetics and Genetic Factors of Atorvastatin in Healthy Korean Subjects
Frontiers in Genetics, 2022 Background: Statins are the most popular agents for the primary and secondary prevention of cardiovascular disease; however, the pharmacokinetic parameters and associated genetic factors in the Korean population have not been fully elucidated. This study
Serim Kim +11 more
doaj +1 more source
Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1+/− Mice
Translational Oncology, 2017 Atorvastatin is widely used to lower blood cholesterol and to reduce risk of cardiovascular disease–associated complications. Epidemiological investigations and preclinical studies suggest that statins such as atorvastatin have antitumor activity for ...
Ming Hong Shen +5 more
doaj +1 more source
Add-on effect of probucol in atherosclerotic, cholesterol-fed rabbits treated with atorvastatin. [PDF]
PLoS ONE, 2014 OBJECTIVE: Lowering the blood concentration of low-density lipoprotein (LDL) cholesterol is the primary strategy employed in treating atherosclerotic disorders; however, most commonly prescribed statins prevent cardiovascular events in just 30% to 40% of
Yuka Keyamura +9 more
doaj +1 more source
Combined Beneficial Effect of Genistein and Atorvastatin on Adipogenesis in 3T3-L1 Adipocytes
Biomolecules, 2021 Genistein (4,5,7-trihydroxyisoflavone) is abundant in various dietary vegetables, especially soybeans, and is known to have not only an estrogenic effect but also an antiadipogenic effect.
Dahae Lee +4 more
doaj +1 more source
Deciphering the Mechanisms of Statin-Ezetimibe Drug Combinations Using Boolean Logical Modeling and Transcriptomic Data. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Drug Combinations offer increased therapeutic efficacy and reduced toxicity compared with single agents. Understanding a drug combination's mechanisms of action (MoA) can provide important insights into therapeutic efficacy. The MoA of many FDA‐approved drugs, however, often remains unclear.
Wang RS +5 more
europepmc +2 more sources
A placebo-controlled trial examining atorvastatin in dyslipidemic patients undergoing CAPD [PDF]
, 2002 A placebo-controlled trial examining atorvastatin in dyslipidemic patients undergoing CAPD.BackgroundIndividuals with chronic renal disease are at high risk of cardiovascular morbidity and mortality, and therefore the management of dyslipidemia is ...
Harris, Kevin P.G. +3 more
core +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2019 The drug–drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs).
Bridget L. Morse +9 more
doaj +1 more source