Results 111 to 120 of about 55,691 (247)

Effects of non‐surgical periodontal therapy on intrabony periodontal defects at different re‐evaluation time points: A systematic review of randomized controlled trials and clinical recommendations

Periodontology 2000, EarlyView.
Abstract Objective The aim of this systematic review and meta‐analysis was to evaluate the longitudinal temporal pattern of periodontal probing depth (PPD) reduction in intrabony periodontal defects following non‐surgical periodontal therapy (NSPT), both as a monotherapy and with adjunctive locally delivered pharmacological agents.
Luca Ramaglia, Vincenzo Iorio‐Siciliano, Leopoldo Mauriello, Andrea Blasi, Anton Sculean   +4 more
wiley   +1 more source

The effects of uninterrupted and interrupted sitting on blood pressure and arterial stiffness in patients with established coronary heart disease

Experimental Physiology, EarlyView.
Abstract Sedentary behaviour is an independent risk factor for cardiovascular disease. In healthy adults, prolonged uninterrupted sitting acutely increases blood pressure (BP) and aortic stiffness; however, these effects can be mitigated with light physical activity interruptions.
Simon Fryer, Eve Scarle, Louise Turner, Arsalan Moinuddin, James Faulkner, Hayley Legg, Craig Paterson, Keeron Stone   +7 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Atorvastatin blocks Sonic Hedgehog medulloblastoma progression through apoptosis

, 2017
Aberrant activation of Sonic Hedgehog signaling transduction leads to formation of numerous malignancies, including medulloblastoma (MB) – the most common malignant pediatric tumor.
Z.I. Abramova, R.E. Gordon
core  

Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug–Drug Interactions for Orforglipron, a Small Molecule Glucagon‐Like Peptide‐1 Receptor Agonist

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 979-990, October 2026.
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse, David E. Coutant, Xiaosu Ma, Sohini Raha, Keerthan Aithal, Clare Nicoll, Luc R. A. Rougée, Shobha Bhattachar   +7 more
wiley   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

[Atorvastatin in secondary prevention]. Ikincil korunmada atorvastatin.

, 2009
During the 10 years of atorvastatin availability in the Turkish market, the physicians have had the opportunity to observe the accumulation of data related to its beneficial effect on clinical endpoints.
Yilmaz, Yeşim, ÖNGEN, Zeki, KARADAĞ, Bilgehan   +2 more
core  

Effect of atorvastatin on phagocytosis of the blue mussels, Mytilus edulis

, 2019
Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms.
Sabrina Glufke (7884569), Udo Kragl (7884563), Stock, Marius, Falfushynska, Halina, Ruth, Wolfgang, Sokolova, Inna M, Fouzia Haider (7883918), Wolfgang Ruth (2325415), Oppermann, Christina, Eileen J Winkel (7884572), Glufke, Sabrina, Marius Stock (7884566), Inna M Sokolova (7398920), Christina Oppermann (7884560), Winkel, Eileen J, Kragl, Udo, Haider, Fouzia, Eugene P Sokolov (7884557), Halina Falfushynska (7398923), Sokolov, Eugene P   +19 more
core   +1 more source

Clinical management of clonal hematopoiesis

Cancer, Volume 132, Issue 18, 15 September 2026.
ABSTRACT Clonal hematopoiesis, particularly clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance, is an age‐related premalignant condition characterized by the expansion of hematopoietic clones carrying somatic mutations.
Kelly S. Chien, Guillermo Garcia‐Manero   +1 more
wiley   +1 more source

Recurrent Symptomatic Hemorrhage in Cerebral Cavernous Malformations After Discontinuation of Atorvastatin or Placebo

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A recent randomized prospective controlled trial demonstrated that atorvastatin for up to 2 years was safe but did not significantly alter rebleeding in cerebral cavernous malformations.
Bader Ali, Robert Shenkar, Justine Lee, Roberto J. Alcazar‐Felix, Richard E. Thompson, Agnieszka Stadnik, Georgio Sader, Sean P. Polster, Kelly D. Flemming, James K. Liao, Matthew Sorrentino, Romuald Girard, Daniel F. Hanley, Issam A. Awad   +13 more
doaj   +1 more source