Results 101 to 110 of about 81,297 (236)

Optimized zein nanospheres for improved oral bioavailability of atorvastatin

International Journal of Nanomedicine, 2015
Fahima M Hashem,1 Majid M Al-Sawahli,2 Mohamed Nasr,1 Osama AA Ahmed3,4 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 2Holding Company for Biological Products and Vaccines, Giza, Egypt; 3Department ...
Hashem FM, Al-Sawahli MM, Nasr M, Ahmed OA   +3 more
doaj  

SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects

Journal of Biomedical Science, 2012
Background The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on SDF-1α expression in rats with AMI.
Qiu Ruofeng, Cai Anping, Dong Yugang, Zhou Yingling, Yu Danqing, Huang Yuli, Zheng Dongdan, Rao Shaoqi, Feng Yingqing, Mai Weiyi   +9 more
doaj   +1 more source

The role of Coenzyme Q10 in statin-associated myopathy [PDF]

, 2009
Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors,\ud are cholesterol-lowering drugs which are frequently used in the primary and secondary\ud prevention of coronary artery disease. Current research and recommendations support\
Kalra, Dr Sanjay
core  

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, EarlyView.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

Recurrent Symptomatic Hemorrhage in Cerebral Cavernous Malformations After Discontinuation of Atorvastatin or Placebo

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A recent randomized prospective controlled trial demonstrated that atorvastatin for up to 2 years was safe but did not significantly alter rebleeding in cerebral cavernous malformations.
Bader Ali, Robert Shenkar, Justine Lee, Roberto J. Alcazar‐Felix, Richard E. Thompson, Agnieszka Stadnik, Georgio Sader, Sean P. Polster, Kelly D. Flemming, James K. Liao, Matthew Sorrentino, Romuald Girard, Daniel F. Hanley, Issam A. Awad   +13 more
doaj   +1 more source

Statin intensity and postoperative mortality following open repair of intact abdominal aortic aneurysm. [PDF]

, 2018
BackgroundThere is a lack of evidence for the association between intensive statin therapy and outcomes following vascular surgery. The aim of this study was to evaluate the association between perioperative statin intensity and in-hospital mortality ...
Alshaikh, HN, Bohsali, F, Gani, F, Malas, M, Nejim, B   +4 more
core  

A Statistical Model for Stroke Outcome Prediction and Treatment Planning

, 2016
Stroke is a major cause of mortality and long--term disability in the world. Predictive outcome models in stroke are valuable for personalized treatment, rehabilitation planning and in controlled clinical trials.
Bhattacharya, Sakyajit, Rajan, Vaibhav, Sarma, G R K, Sengupta, Abhishek   +3 more
core   +1 more source

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial. [PDF]

, 2015
OBJECTIVE: T-cell activation independently predicts mortality, poor immune recovery and non-AIDS illnesses during combination antiretroviral therapy (cART). Atorvastatin showed anti-immune activation effects among HIV-infected cART-naïve individuals.
Bayigga, Lois, Elliott, Alison, Joloba, Moses, Kaleebu, Pontiano, Kambugu, Andrew D, Kamya, Moses R, Kiragga, Agnes, Mayanja-Kizza, Harriet, Nabatanzi, Rose, Nakanjako, Damalie, Sekaly, Rafick, Ssinabulya, Isaac   +11 more
core   +1 more source

Catalytic Scalable Synthesis of Polyketides Enabled by Chiral Brønsted Acid‐Catalyzed Asymmetric Allylborations

The Chemical Record, EarlyView.
The scalable synthesis of target molecules is crucial for applications such as biological evaluation in medicinal chemistry and even industrial production. We described recent advances in chiral Brønsted acid–catalyzed asymmetric allylboration, which enables access to previously elusive chiral building blocks, and highlight its application to the ...
Shigenobu Umemiya, Masahiro Terada
wiley   +1 more source