Results 151 to 160 of about 55,691 (247)

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Atorvastatin Exerts Context-Dependent Metabolic and Beneficial Effects on Behavior and Apoptotic Signaling in a Cafeteria Diet-Induced Metabolic Dysfunction Model. [PDF]

Neurochem Res
Diogo ÍL, Maia GAS, Garcia IJP, de Lima Santos H, Cortes VF, Barbosa LA, Chaves VE, Carvalho LED.   +7 more
europepmc   +1 more source

Effect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials

, 2019
Mingfeng Ma,1,2 Lixia Bu,3 Li Shi,1 Renwei Guo,3 Bin Yang,2 Huili Cao,2 Liangping Luo,4 Ligong Lu5 1Department of Cardiology, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People’s Hospital), Zhuhai, Guangdong 519000, People’s ...
Bu L, Lu L, Shi L, Cao H, Ma M, Luo L, Yang B, Guo R   +7 more
core  

A Catalogue of Dispensation Lengths for Building Treatment Episodes—Application of the Waiting Time Distribution to All Commonly Prescribed Drugs in Denmark

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Background In pharmacoepidemiologic research, correct assignment of the length of single dispensation is critical to build treatment episodes. The parametric reverse waiting time distribution (rWTD) is a particularly attractive data‐driven method to estimate dispensation lengths.
Mette Reilev, Lotte Rasmussen, Jonas Kanstrup Olsen, Martin Thomsen Ernst, Saad Hanif Abbasi, Rikke Wesselhoeft, Mette Bliddal, Jesper Hallas, Henrik Støvring   +8 more
wiley   +1 more source

A cofactor‐promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The Lyme disease pathogen Borrelia burgdorferi contains a highly reduced genome lacking many primary metabolic pathways. However, B. burgdorferi retains the mevalonate pathway that synthesizes isopentenyl pyrophosphate (IPP), the precursor to the peptidoglycan carrier lipid.
Isaac A. Paddy, Joshua McCausland, Madelyn Frazier, Poulami Chatterjee, Mekedlawit Setegne, Oliv Eidam, Christine Jacobs‐Wagner, Laura M. K. Dassama   +7 more
wiley   +1 more source

The impact of concomitant use of rosuvastatin or atorvastatin plus clopidogrel on the platelet inhibition and clinical outcomes in acute large-vessel minor stroke or TIA: A randomized controlled multi-center trial, the ROCATIS-1 trial. [PDF]

Ther Adv Neurol Disord
Zeinhom MG, Sayed Ismaiel MG, Khalil MFE, Elmesallami AG, Khalil GAE, Akl AZO, Georgy SS, Abbas AA, Kerolos YSS, Abdeldayem SM, Khalil EHE, Mostafa E, Youssif TYO, Egila AAE, Alkhalefeh AG, Hassan AM, Zedan TS, Ghoname AE, Mahmoud ELA, Mushtaque A, Abdelkhalek AM, Ghazi EAA, Ahmed SR.   +22 more
europepmc   +1 more source

Comparative effects of atorvastatin and rosuvastatin on inflammatory biomarkers: a systematic review and meta-analysis of randomized head-to-head trials. [PDF]

BMC Cardiovasc Disord
Omayer A, Mohamed MI, Shahid M, Hoque SMH, Mohamed NEAM, Elsayed EMA, Nassar M, Ahmed T, Sattar Y.   +8 more
europepmc   +1 more source

Multicomponent Analysis of Antihyperlipidemic Drugs: Integrating Analytical Quality by Design and Multi‐Metric Green Liquid Chromatography

SEPARATION SCIENCE PLUS, Volume 9, Issue 9, September 2026.
Robust HPLC method quantifies four antihyperlipidemic drugs. Central composite design optimized the analytical conditions. Achieved complete isocratic separation in under 10 min. Multiple green metrics confirmed excellent environmental sustainability. Validated method successfully analyzed commercial binary formulations.
Venkatesh Bukkapatnam, Raja Sundararajan
wiley   +1 more source

Thermoresponsive Solid Dispersion to Enhance Dissolution Profile of Atorvastatin Calcium: An Industrially Sustainable Alternative to Conventional Approaches. [PDF]

Pharmaceutics
Sherif AY, Ibrahim MA.
europepmc   +1 more source