Results 1 to 10 of about 1,799,367 (292)
The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework. [PDF]
Reprod Med BiolABSTRACT Purpose Mammalian sperm require a large amount of ATP to sustain motility. While glycolysis and oxidative phosphorylation (OXPHOS) are established ATP sources, they cannot fully explain motility maintenance under glucose‐deprived conditions.
Oishi K +9 more
europepmc +2 more sources
Searching for alternative toxicology testing systems: The response of isolated mitochondria from Saccharomyces cerevisiae, potato tuber, and mouse liver to a toxic insult [PDF]
Trends in Pharmaceutical Sciences, 2021 Mitochondria are cellular power plants known as essential organelles for energy (ATP) metabolism. However, today it is evident that various vital compounds are partially or exclusively synthesized in mitochondria. Moreover, this organelle plays a pivotal
Pouria Mobasher +5 more
doaj +1 more source
IGF-1 as a Potential Therapy for Spinocerebellar Ataxia Type 3
Biomedicines, 2022 Although the effects of growth hormone (GH) therapy on spinocerebellar ataxia type 3 (SCA3) have been examined in transgenic SCA3 mice, it still poses a nonnegligible risk of cancer when used for a long term. This study investigated the efficacy of IGF-1,
Yong-Shiou Lin +5 more
doaj +1 more source
A pilot study: handgrip as a predictor in the disease progression of SCA3
Orphanet Journal of Rare Diseases, 2023 Background Spinocerebellar ataxia type 3 (SCA3) is an inherited, autosomal, and rare neurodegenerative disease. Serum/plasma biomarkers or functional magnetic resonance imaging used to assess progression, except for neurological examinations, is either ...
Chungmin Chiu +8 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 2005 We present a mesoscopic model for ATP synthesis by F 1 F o ATPase. The model combines the existing experimental knowledge of the F 1 enzyme into a consistent mathematical model that illuminates how the stages in synthesis are related to the protein structure.
Jianhua, Xing +2 more
openaire +2 more sources
ATP‐induced ATP release from astrocytes [PDF]
Journal of Neurochemistry, 2003 AbstractPropagation of interastrocyte Ca2+waves is mediated by diffusion of extracellular adenosine triphosphate (ATP), and may require regenerative release of ATP. The ability of ATP to initiate release of intracellular ATP was assessed by labeling adenine nucleotide pools in astrocyte cultures with14C‐adenine.
Christopher M, Anderson +2 more
openaire +2 more sources
Immunity & Ageing, 2022 Background Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure of mitochondrial function in aging, with the temporal profile of serum high-sensitivity C-reactive protein and mortality ...
I-Chien Wu +9 more
doaj +1 more source
ATP and cancer immunosurveillance
EMBO Journal, 2021 While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic metabolism of all the cellular compartments that form the tumor microenvironment (TME), extracellular ATP operates as a potent signal transducer. The net effects
O. Kepp +6 more
semanticscholar +1 more source
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
bioRxiv, 2020 Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo +13 more
semanticscholar +1 more source
Optical ATP biosensor for extracellular ATP measurement [PDF]
Biosensors and Bioelectronics, 2013 Extracellular Adenosine-5'-triphosphate (ATP) is an important multi-functional molecule which can mediate numerous physiological activities by activating purinergic P2 receptors. The objective of this study was to develop a novel optical ATP sensor for in-situ extracellular ATP measurement in biological tissues.
C, Wang, C-Y C, Huang, W-C, Lin
openaire +2 more sources