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Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol-Induced Heart Failure. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Vicente M +6 more
europepmc +2 more sources
Host Translational Control by Stress Granules Promotes <i>Mycobacterium tuberculosis</i> Pathogenesis. [PDF]
MedComm (2020)During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial complex I subunits (Ndufa12), leading to suppressed cap‐dependent translation, reduced mitochondrial activity, and impaired innate immune responses.
Kim J +9 more
europepmc +2 more sources
ATP Synthase: Structure, Function and Inhibition
Biomolecular Concepts, 2019 Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through ...
Neupane Prashant +3 more
doaj +2 more sources
Searching for alternative toxicology testing systems: The response of isolated mitochondria from Saccharomyces cerevisiae, potato tuber, and mouse liver to a toxic insult [PDF]
Trends in Pharmaceutical Sciences, 2021 Mitochondria are cellular power plants known as essential organelles for energy (ATP) metabolism. However, today it is evident that various vital compounds are partially or exclusively synthesized in mitochondria. Moreover, this organelle plays a pivotal
Pouria Mobasher +5 more
doaj +1 more source
IGF-1 as a Potential Therapy for Spinocerebellar Ataxia Type 3
Biomedicines, 2022 Although the effects of growth hormone (GH) therapy on spinocerebellar ataxia type 3 (SCA3) have been examined in transgenic SCA3 mice, it still poses a nonnegligible risk of cancer when used for a long term. This study investigated the efficacy of IGF-1,
Yong-Shiou Lin +5 more
doaj +1 more source
A pilot study: handgrip as a predictor in the disease progression of SCA3
Orphanet Journal of Rare Diseases, 2023 Background Spinocerebellar ataxia type 3 (SCA3) is an inherited, autosomal, and rare neurodegenerative disease. Serum/plasma biomarkers or functional magnetic resonance imaging used to assess progression, except for neurological examinations, is either ...
Chungmin Chiu +8 more
doaj +1 more source
ATP and cancer immunosurveillance
EMBO Journal, 2021 While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic metabolism of all the cellular compartments that form the tumor microenvironment (TME), extracellular ATP operates as a potent signal transducer. The net effects
O. Kepp +6 more
semanticscholar +1 more source
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
bioRxiv, 2020 Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo +13 more
semanticscholar +1 more source
Journal of Emergencies, Trauma and Shock, 2022 Introduction: Triage is a crucial process not only to identify sick patients and prioritize prompt management but also to foster efficient resource utilization.
Satish Kumar Singh +9 more
doaj +1 more source
Translating the Medieval Icelandic Romance-Sagas [PDF]
, 2014 This short note surveys recent work done on translating romances composed in medieval Iceland into English, focusing on translations produced at the University of Leeds.
Hall, ATP
core +1 more source