Results 21 to 30 of about 759,738 (176)

Lecithin coenzyme Q10 restores mitochondrial dynamics and alleviates hepatic dysfunction in high-fat Diet-Fed db/db mice

Lipids in Health and Disease
Background/Objectives This study investigated the metabolic and pathological effects of a high-fat diet (HFD) in db/db mice and evaluated the therapeutic efficacy of various Coenzyme Q10 (CoQ10) products.
Chen-Ling Kuo, Chih-Chung Wu, Yu-Shan Cheng, Ching-Shan Huang, Chin-San Liu, Shih-Li Su   +5 more
doaj   +1 more source

Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study

Immunity & Ageing, 2022
Background Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure of mitochondrial function in aging, with the temporal profile of serum high-sensitivity C-reactive protein and mortality ...
I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ling Chen, Pei-Fen Chen, Ray-Chin Wu, Chen-Wei Huang, Chao A. Hsiung, Chih-Cheng Hsu   +9 more
doaj   +1 more source

Targeting the Key Enzymes of Abnormal Fatty Acid β-oxidation as a Potential Strategy for Tumor Therapy

Frontiers in Bioscience-Landmark, 2022
Fatty acid metabolism has attracted extensive attention for its key role in the occurrence and development of tumors. Fatty acids not only participate in the biosynthesis of phospholipids in the membrane to overcome the demand for rapidly proliferating ...
Hongdan Chen, Zeyu Yang, Yiceng Sun, Supeng Yin, Mi Tang, Fan Zhang   +5 more
doaj   +1 more source

Diabetes‐Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high‐fat, high‐sucrose diet (HFHSD), conceivably leading to bladder underactivity.
Mahsa Borhani Peikani, Brian A. Perrino, Violeta N. Mutafova‐Yambolieva   +2 more
wiley   +1 more source

Extracellular ATP and Neurodegeneration

Current Drug Target -CNS & Neurological Disorders, 2003
ATP is a potent signaling molecule abundantly present in the CNS. It elicits a wide array of physiological effects and is regarded as the phylogenetically most ancient epigenetic factor playing crucial biological roles in several different tissues. These can range from neurotransmission, smooth muscle contraction, chemosensory signaling, secretion and ...
Volonté, Cinzia, Amadio, Susanna, Cavaliere, Fabio, D'Ambrosi, Nadia, Vacca, Fabrizio, Bernardi, Giorgio   +5 more
openaire   +3 more sources

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Simulated Microgravity Reprograms Host Cell Architecture and Mitochondrial Function, Altering Toxoplasma gondii Growth

FASEB BioAdvances, Volume 8, Issue 7, July 2026.
Simulated microgravity (SMG) induces host‐cell‐specific mitochondrial remodeling that differentially regulates T. gondii intracellular growth. Mitochondrial dysfunction with reduced ATP production is associated with impaired parasite invasion and growth in HFF, whereas mitochondrial adaptation with increased ATP production in Vero cells is associated ...
Musfika Tasnim Shirin, Takafumi Yamada, Daisuke Kondoh, Hiroki Bochimoto, Kentaro Kato   +4 more
wiley   +1 more source

Changes in contractile characteristics of rat skeletal muscles associated with P2-receptor activation after spinal cord transection [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Traumatic spinal cord and peripheral-nerve injury is associated with release of proinflammatory cytokines and chemokines, which may stimulate neuronal activity.
Adel E. Khairullin, Dina V. Efimova, Marat A. Mukhamedyarov, Maxim E. Baltin, Tatiana V. Baltina, Sergey N. Grishin, Airat U. Ziganshin   +6 more
doaj   +1 more source

Selective recognition of ATP by multivalent nano-assemblies of bisimidazolium amphiphiles through “turn-on” fluorescence response

Beilstein Journal of Organic Chemistry, 2020
Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment.
Rakesh Biswas, Surya Ghosh, Shubhra Kanti Bhaumik, Supratim Banerjee   +3 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, Volume 4, Issue 2, June 2026.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source