Results 31 to 40 of about 969,519 (271)

Sympathetic nerve-derived ATP regulates renal medullary blood flow via vasa recta pericytes [PDF]

, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins. We have previously shown that exogenous ATP causes constriction of vasa
Peppiatt-Wildman, C. M., C. M. Peppiatt-Wildman, Scott S Wildman, C. Crawford, Wildman, Scott S.P., Kennedy-Lydon, T. M., M. C. Kelly, Wildman, S. S. P., Peppiatt-Wildman, Claire M., S. S. P. Wildman, T. M. Kennedy-Lydon, Kelly, M. C., Crawford, C.   +12 more
core   +1 more source

Extracellular ATP and Neurodegeneration

Current Drug Target -CNS & Neurological Disorders, 2003
ATP is a potent signaling molecule abundantly present in the CNS. It elicits a wide array of physiological effects and is regarded as the phylogenetically most ancient epigenetic factor playing crucial biological roles in several different tissues. These can range from neurotransmission, smooth muscle contraction, chemosensory signaling, secretion and ...
Volonté, Cinzia, Amadio, Susanna, Cavaliere, Fabio, D'Ambrosi, Nadia, Vacca, Fabrizio, Bernardi, Giorgio   +5 more
openaire   +3 more sources

Lecithin coenzyme Q10 restores mitochondrial dynamics and alleviates hepatic dysfunction in high-fat Diet-Fed db/db mice

Lipids in Health and Disease
Background/Objectives This study investigated the metabolic and pathological effects of a high-fat diet (HFD) in db/db mice and evaluated the therapeutic efficacy of various Coenzyme Q10 (CoQ10) products.
Chen-Ling Kuo, Chih-Chung Wu, Yu-Shan Cheng, Ching-Shan Huang, Chin-San Liu, Shih-Li Su   +5 more
doaj   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, EarlyView.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Zoltan Oltvai, Zoltan N. Oltvai   +2 more
core   +3 more sources

Changes in contractile characteristics of rat skeletal muscles associated with P2-receptor activation after spinal cord transection [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Traumatic spinal cord and peripheral-nerve injury is associated with release of proinflammatory cytokines and chemokines, which may stimulate neuronal activity.
Adel E. Khairullin, Dina V. Efimova, Marat A. Mukhamedyarov, Maxim E. Baltin, Tatiana V. Baltina, Sergey N. Grishin, Airat U. Ziganshin   +6 more
doaj   +1 more source

Selective recognition of ATP by multivalent nano-assemblies of bisimidazolium amphiphiles through “turn-on” fluorescence response

Beilstein Journal of Organic Chemistry, 2020
Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment.
Rakesh Biswas, Surya Ghosh, Shubhra Kanti Bhaumik, Supratim Banerjee   +3 more
doaj   +1 more source

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of UQCRC1 Mutation

Cells
The intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson’s disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability ...
Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu   +7 more
doaj   +1 more source