Results 31 to 40 of about 759,738 (176)

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults

Communications Medicine
Background As the population ages, a rising mortality burden is attributed to deaths in older adults, particularly deaths from inflammation-related chronic non-communicable diseases. The synergism between aging and inflammation remains unclear.
I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Pei-Fen Chen   +4 more
doaj   +1 more source

Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial–Neuronal Interactions in a Genetic Parkinson’s Disease Model of UQCRC1 Mutation

Cells
The intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson’s disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability ...
Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu   +7 more
doaj   +1 more source

Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines

Nutrition and Dietary Supplements, 2023
Mahendra Kumar Trivedi,1 Alice Branton,1 Dahryn Trivedi,1 Sambhu Mondal,2 Snehasis Jana2 1Trivedi Global, Inc, Research & Development, Henderson, Nevada, USA; 2Trivedi Science Research Laboratory Pvt.
Trivedi MK, Branton A, Trivedi D, Mondal S, Jana S   +4 more
doaj  

Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1

Journal of Immunotoxicology, 2020
Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immune suppression/
Sajad Najafi, Gholamreza Mohammadi, Mehrdad Mohri, Saman Hosseinkhani, Jalil Mehrzad   +4 more
doaj   +1 more source

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Formoterol Acting via β2-Adrenoreceptor Restores Mitochondrial Dysfunction Caused by Parkinson’s Disease-Related UQCRC1 Mutation and Improves Mitochondrial Homeostasis Including Dynamic and Transport

Biology
Formoterol, a β2-adrenergic receptor (β2AR) agonist, shows promise in various diseases, but its effectiveness in Parkinson’s disease (PD) is debated, with unclear regulation of mitochondrial homeostasis.
Jui-Chih Chang, Huei-Shin Chang, Yi-Chun Chao, Ching-Shan Huang, Chin-Hsien Lin, Zhong-Sheng Wu, Hui-Ju Chang, Chin-San Liu, Chieh-Sen Chuang   +8 more
doaj   +1 more source

KIAA0753 promotes glucose and energy metabolism in osteoblasts inhibited by diabetes

陆军军医大学学报
Objective To explore the effect of KIAA0753 on glucose and energy metabolism in mouse embryonic osteoblast precursor cell line MC3T3-E1. Methods The GSE182286 datasets of patients with Joubert syndrome acquired from the Gene Expression Comprehensive ...
LI Mengxue, LI Mengxue, WANG Jichun, WANG Jichun, LI Letai   +4 more
doaj   +1 more source

Closing a Key Gap in DSCSA Compliance with Credentialing

Blockchain in Healthcare Today, 2023
In this session, the Open Credentialing Initiative (OCI) introduces the concept and practical application of electronic credentials. The audience will learn about their use in the context of DSCSA and how they enable timely compliance with the DSCSA ...
Bob Celeste, David Kessler
doaj   +1 more source

A new electoral bottom-up model of institutional governance

Scientific Reports
The sustainable governance of Global Risky Commons (GRC)—global commons in the presence of a sizable risk of overall failure—is ubiquitous and requires a global solution. A prominent example is the mitigation of the adverse effects of global warming.
Carlos M. Garrido, Francisco C. Santos, Elias Fernández Domingos, Ana M. Nunes, Jorge M. Pacheco   +4 more
doaj   +1 more source