Results 151 to 160 of about 1,971,906 (181)
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EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATES*
Annual Review of Genomics and Human Genetics, 2005▪ Abstract The ATP-binding cassette (ABC) superfamily of genes encode membrane proteins that transport a diverse set of substrates across membranes. Mutations in ABC transporters cause or contribute to many different Mendelian and complex disorders including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, hypercholesterolemia, and ...
Tarmo Annilo, Michael Dean
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ATP-binding cassette (ABC) transporters in atherosclerosis
Current Atherosclerosis Reports, 2002Macrophages play a central role in the initiation and progression of atherosclerotic lesions. In the nascent lesion, macrophages transform into foam cells through the excessive accumulation of cholesteryl esters. Dysfunctional lipid homeostasis in macrophages and foam cells ultimately results in the breakdown of membrane integrity and cell death ...
Gerd, Schmitz, Wolfgang E, Kaminski
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Interactions of organophosphorus pesticides with ATP-binding cassette (ABC) drug transporters
Xenobiotica, 2022Although pharmaceutical companies have to study drug-transporter interaction, environmental contaminant interactions with these transporters are not well characterised. In this study, we demonstrated using in vitro transfected cell line that some organophosphorus pesticides are able to interact with drug efflux transporters like P-glycoprotein, BCRP ...
Chedik, Lisa +4 more
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Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters [PDF]
International Journal of Molecular Sciences, 2017 The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1, ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids that allow their degradation inside the organelle. Defective ABCD1 leads to the accumulation of very long-chain fatty acids and is associated with a complex and severe neurodegenerative
Mustapha Cherkaoui-Malki +2 more
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ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
Journal of Evidence-Based Medicine, 2021AbstractThe ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane protein families existing in wide spectrum of organisms from prokaryotes to human. ABC transporters are also known as efflux pumps because they mediate the cross‐membrane transportation of various endo‐ and xenobiotic molecules energized by ATP hydrolysis ...
Jing‐Quan Wang +8 more
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International Journal of Molecular Sciences, 2019 ATP-binding cassette (ABC) transporters, a large class of transmembrane proteins, are widely found in organisms and play an important role in the transport of xenobiotics.
Swapan Chakrabarty +2 more
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Unravelling the folding and stability of an ABC (ATP-binding cassette) transporter
Biochemical Society Transactions, 2011Prokaryotic importers from the large family of ABC (ATP-binding cassette) transporters comprise four separate subunits: two membrane-embedded and two cytoplasmic ATP-binding subunits. This modular construction makes them ideal candidates for studies of the intersubunit interactions of membrane protein complexes that contain both hydrophobic and ...
Booth, PJ, Di bartolo, N
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ATP-binding cassette (ABC) transporters: structures and roles in bacterial pathogenesis
Journal of Zhejiang University: Science BAdenosine triphosphate (ATP)-binding cassette (ABC) transporter systems are divided into importers and exporters that facilitate the movement of diverse substrate molecules across the lipid bilayer, against the concentration gradient. These transporters comprise two highly conserved nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs).
Sheila Nathan +2 more
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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Advanced Drug Delivery Reviews, 2003Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of proteins have a major impact on the pharmacological behavior of most of the drugs in use today. Pharmacological properties affected by ABC transporters include the oral bioavailability, hepatobiliary, direct intestinal, and urinary excretion of drugs and drug ...
Johan W. Jonker, Alfred H Schinkel
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Availability and applications of ATP-binding cassette (ABC) transporter blockers
Applied Microbiology and Biotechnology, 2007ATP-binding cassette (ABC) transporters encompass membrane transport proteins that couple the energy derived from ATP hydrolysis to the translocation of solutes across biological membranes. The functions of these proteins include ancient and conserved mechanisms related to nutrition and pathogenesis in bacteria, spore formation in fungi, and signal ...
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