Results 141 to 150 of about 1,808,366 (209)

Proteomic Profiling of Xenobiotic and Nutrient Transporters in Human Placenta of Different Gestational Ages

Clinical Pharmacology &Therapeutics, EarlyView.
The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus. The placenta is also responsible for the uptake and/or exchange of xenobiotics, including medications, between the maternal and fetal bloodstreams. An estimated 40–80% of women take medications or drugs during pregnancy.
Eric M. Weaver, Ariel Topletz‐Erickson, Edward J. Kelly, Joanne Wang, Nina Isoherranen, Jashvant D. Unadkat, Samuel L.M. Arnold   +6 more
wiley   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Interactions between lactobacillus and yeast: A recent update

Food Biomacromolecules, EarlyView.
Abstract Lactobacillus and yeast are microorganisms widely distributed in nature. Their interactions significantly impact fermentation processes, human health, and medical care. However, there is a lack of a systematic summary of the characteristics of these interactions, and the mechanisms underlying these interactions remain unclear.
Yang Chen, Mengyuan Liu, Mengchen Li, Zhiyun Yue, Yang Mu, Chao Wang, Lusha Xia, Junjun Gao, Mingye Peng, Ran Wang, Mengzhou Zhou   +10 more
wiley   +1 more source

Detection of Mitochondrial Respiratory Chain Complexes by BN‐PAGE and Its Applications

Future Postharvest and Food, EarlyView.
Schematic workflow for the isolation and BN‐PAGE analysis of plant mitochondrial respiratory chain complexes. ABSTRACT Blue native polyacrylamide gel electrophoresis (BN‐PAGE) is a core technique for separating and characterizing plant mitochondrial respiratory chain complexes.
Jinghan Zhang, Jinyan Li, Hongliang Zhu
wiley   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus

, 2008
Leukocyte ATP-Binding Cassette Transporter G1 Gene Expression is Reduced in Type 2 Diabetes Mellitus Reverse cholesterol transport Reverse cholesterol transport is a pathway which transports cholesterol from extrahepatic cells and tissues to the liver ...
Wong, Y, Tan, KCB, Zhou, H, Shiu, SWM
core  

KLF15 as a Metabolic Gatekeeper Linking Drug Metabolism, Toxicity, and Precision Therapeutics

iNew Medicine, EarlyView.
KLF15‐mediated metabolic preconditioning links metabolic state to drug disposition, therapeutic efficacy, and adverse effects, extending classical xenobiotic sensing toward precision pharmacology. ABSTRACT Krüppel‐like factor 15 (KLF15) is emerging as a metabolic‐state‐sensitive regulator of hepatic endobiotic and xenobiotic metabolism.
Shilin Li, Xue Li, Zhengding Su, Shuxin Han   +3 more
wiley   +1 more source