Results 141 to 150 of about 59,687 (251)

Metrnl: A Novel Therapeutic Target in Atherosclerosis

open access: yesiNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

open access: yesInterdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang   +11 more
wiley   +1 more source

Repeated Ivermectin Treatment Induces Ivermectin Resistance in Strongyloides ratti by Upregulating the Expression of ATP-Binding Cassette Transporter Genes. [PDF]

open access: yesAm J Trop Med Hyg, 2021
Sengthong C   +11 more
europepmc   +1 more source

Diagnostic Performance of Direct PCR Assay for Candida auris Detection: A Comparison of Liquid Amies Transport Medium and Fungal Enrichment Broth

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study evaluated a direct PCR assay for rapid Candida auris screening from skin swabs using two transport media. The direct PCR assay demonstrated high sensitivity (92.0%–96.0%) and rapid turnaround time (~3 h). Liquid Amies medium showed a more favorable specificity profile, supporting its practical utility for screening.
Jung‐ah Kim   +4 more
wiley   +1 more source

Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export. [PDF]

open access: yesImmunity
Shinde O   +11 more
europepmc   +1 more source

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