Results 51 to 60 of about 127,756 (395)

Transcriptional Profiling Identifies Two Members of the ATP-binding Cassette Transporter Superfamily Required for Sterol Uptake in Yeast*

Journal of Biological Chemistry, 2002
In contrast to lipoprotein-mediated sterol uptake, free sterol influx by eukaryotic cells is poorly understood. To identify components of non-lipoprotein-mediated sterol uptake, we utilized strains of Saccharomyces cerevisiae that accumulate exogenous ...
L. Wilcox, D. Balderes, B. Wharton, A. Tinkelenberg, G. Rao, S. Sturley   +5 more
semanticscholar   +1 more source

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

Frontiers in Oncology, 2019
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic.
Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source

A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity [PDF]

, 2011
We previously identified the lpa1 (low phytic acid) 280-10 line that carries a mutation conferring a 90% reduction in phytic acid (InsP6) content. In contrast to other lpa mutants, lpa1(280-10) does not display negative pleiotropic effects.
Bollini, Roberto, Brearley, Charles A., Campion, Bruno, Cassani, Elena, Doria, Enrico, Forti, Luca, Nielsen, Erik, Panzeri, Dario, Pilu, Roberto, Sparvoli, Francesca, Tagliabue, Giovanni   +10 more
core   +1 more source

Mechanistic diversity in ATP-binding cassette (ABC) transporters [PDF]

Nature Structural & Molecular Biology, 2016
Nature Structural & Molecular Biology, 23 (6)
Kaspar P. Locher
openalex   +4 more sources

Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis.

PLoS Biology, 2007
We measured the amplitude of conformational motion in the ATP-binding cassette (ABC) transporter MsbA upon lipopolysaccharide (LPS) binding and following ATP turnover by pulse double electron-electron resonance and fluorescence homotransfer. The distance
Peter P Borbat, Kavitha Surendhran, Marco Bortolus, Ping Zou, Jack H Freed, Hassane S Mchaourab   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Characterization of bacteriocin ABC transporter ATP-binding protein produced by a newly isolated Enterococcus casseliflavus MI001 strain

Beni-Suef University Journal of Basic and Applied Sciences, 2019
Background ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes.
Indira Mikkili, Venkateswarulu TC, Abraham Peele Karlapudi, Vidya Prabhakar Kodali, Krupanidhi Srirama   +4 more
doaj   +1 more source

A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]

, 2018
Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI, Cowan, Don A, Makhalanyane, Thulani P, Pierneef, Rian, Van de Peer, Yves, Van Goethem, Marc W   +5 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Single-molecule visualization of conformational changes and substrate transport in the vitamin B12 ABC importer BtuCD-F

Nature Communications, 2017
The vitamin B12 importer BtuCD-F is a type II ATP-binding cassette transporter. Here the authors use single-molecule fluorescence techniques to analyse ATP hydrolysis and substrate transport in individual BtuCD-F complexes embedded in liposomes, and ...
Joris M. H. Goudsmits, Dirk Jan Slotboom, Antoine M. van Oijen   +2 more
doaj   +1 more source