Results 121 to 130 of about 2,025,163 (218)

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

FXR-mediated down-regulation of CYP7A1 dominates LXRα in long-term cholesterol-fed NZW rabbits

Journal of Lipid Research, 2003
We investigated how cholesterol feeding regulates cholesterol 7α-hydroxylase (CYP7A1) via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor α (LXRα) in New Zealand white rabbits.
Guorong Xu, Hai Li, Lu-xing Pan, Quan Shang, Akira Honda, M. Ananthanarayanan, Sandra K. Erickson, Benjamin L. Shneider, Sarah Shefer, Jaya Bollineni, Barry M. Forman, Yasushi Matsuzaki, Frederick J. Suchy, G. Stephen Tint, Gerald Salen   +14 more
doaj   +1 more source

Impact of Methyl-β-Cyclodextrin and Apolipoprotein A-I on The Expression of ATP-Binding Cassette Transporter A1 and Cholesterol Depletion in C57BL/6 Mice Astrocytes. [PDF]

Cell J, 2021
Azizidoost SH, Babaahmadi-Rezaei H, Nazeri Z, Cheraghzadeh M, Kheirollah A.   +4 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

Journal of Lipid Research, 2003
Defects in the gene encoding for the ATP binding cassette (ABC) transporter A1 (ABCA1) were shown to be one of the genetic causes for familial hypoalphalipoproteinemia (FHA). We investigated the role of ABCA1-mediated cholesterol efflux in Dutch subjects
G. Kees Hovingh, Michel J.A. van Wijland, Alison Brownlie, Radjesh J. Bisoendial, Michael R. Hayden, John J.P. Kastelein, Albert K. Groen   +6 more
doaj   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Supplementary Data from Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

, 2009
Supplementary Data from Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette ...
Michelle A. Rudek (670366), Shuiying Hu (10268480), Ming Zhao (48501), Ryan Franke (14975605), Shelley Orwick (8371137), Alex Sparreboom (236030), Zhaoyuan Chen (11130801), Sharyn D. Baker (14918718)   +7 more
core   +1 more source

Molecular and Functional Interaction of the ATP-binding Cassette Transporter A1 with Fas-associated Death Domain Protein

, 2002
ATP-binding cassette transporter A1 (ABCA1) is a major regulator of cellular cholesterol and phospholipid homeostasis. Its function has not been fully characterized and may depend on the association with additional proteins. To identify ABCA1-interacting
Aslanidis, Charalampos, Drobnik, Wolfgang, Schmitz, Gerd, Ritter, Mirko, Bared, Salim Maa, Buechler, Christa   +5 more
core   +1 more source

Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.: BMP and LXRs/ABCs pathway in macrophages

, 2013
International audienceOBJECTIVE: Endosomal signature phospholipid bis(monoacylglycero)phosphate (BMP) has been involved in the regulation of cellular cholesterol homeostasis.
Arnal-Levron, Maud, Kobayashi, Toshihide, Sakaï, Shota, Moulin, Philippe, Luquain-Costaz, Céline, Lefai, Etienne, Makino, Asami, Guichardant, Michel, Lagarde, Michel, Markina, Daria, Yamashita, Shizuya, Euthine, Vanessa, Delton-Vandenbroucke, Isabelle   +12 more
core   +1 more source

Characterization of Oligomeric Human ATP Binding Cassette Transporter A1 [PDF]

Journal of Biological Chemistry, 2004
Maxime Denis, Bassam Haidar, Michel Marcil, Michel Bouvier, Larbi Krimbou, Jacques Genest   +5 more
openaire   +1 more source