Results 191 to 200 of about 26,668 (221)
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ATP-binding cassette transporter A1
Current Opinion in Lipidology, 2014ATP-binding cassette transporter A1 (ABCA1) facilitates cellular cholesterol efflux to lipid-poor apolipoprotein AI (apoAI) and plays a key role in the formation and function of HDL. This review summarizes the advances and new insights in the role of ABCA1 in cardiovascular and metabolic diseases from studies in genetically engineered mice.Recent ...
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ATP binding cassette transporter A1 - key roles in cellular lipid transport and atherosclerosis
Molecular and Cellular Biochemistry, 2002ATP-binding cassette transporter A1 (ABCA1) was recently recognized as the mutant molecule responsible for Tangier disease with low HDL levels, accumulation of cholesteryl esters in tissues, and increased risk of cardiovascular disease. Extensive studies for the past 2 years have recognized the critical role of ABCA1 in cholesterol and phospholipid ...
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Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux
Cardiovascular & Hematological Disorders-Drug Targets, 2014Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
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Current Opinion in Lipidology, 2005
The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development ...
Miranda, Van Eck +4 more
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The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development ...
Miranda, Van Eck +4 more
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The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol Efflux
Biochemistry, 2007ABCA1 is a key element of cholesterol efflux, but the mechanism of ABCA1-dependent cholesterol efflux is still unclear. Monoclonal antibodies against ABCA1 were used to map functional domains of ABCA1. Two antibodies were directed against a fragment of the first extracellular loop of ABCA1, and the third antibody was directed against a fragment of the ...
Nigora, Mukhamedova +4 more
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The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients
International Journal of Obesity, 2009ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux. We have investigated whether the expression of these transporters/receptor is altered in overweight and obese patients, and the potential association ...
M, Xu, H, Zhou, J, Wang, C, Li, Y, Yu
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Ins and outs of the ATP-binding cassette transporter A1
Current Opinion in Lipidology, 2016Dmitri, Sviridov, Yury I, Miller
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[Association of ATP-binding cassette transporter A1 R219K polymorphism with atrial fibrillation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010To investigate the association of ATP binding cassette transporter A1 (ABCA1) gene R219K polymorphisms with atrial fibrillation (AF) in Chinese population.A total of 250 patients with AF and 250 control subjects were selected. Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine the ABCA1 genotype, and the
Liang-Chuan, Chen +6 more
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[Screening and identification of the upregulators of ATP-binding cassette transporter A1].
Yao xue xue bao = Acta pharmaceutica Sinica, 2013ATP-binding cassette transporter A1 (ABCA1) promotes cholesterol and phospholipid efflux from cells to lipid-poor apolipoprotein A-I (apoA-I), and plays a key role in the initial steps of the whole process of reverse cholesterol transport (RCT). Upregulation of ABCA1 is beneficial for atherosclerosis (AS) prevention and/or therapy, which indicated that
Yan-Ni, Xu +7 more
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The human ATP‐binding cassette (ABC) transporter superfamily
Human Mutation, 2022Michael C Dean +2 more
exaly