Results 171 to 180 of about 2,025,163 (218)

Effects of Pravastatin on the Expression of ATP-Binding Cassette Transporter A1

The Journal of Pharmacology and Experimental Therapeutics, 2004
In vitro inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase causes the suppression of liver X receptor (LXR) activity. Because LXR regulates the expression of ATP-binding cassette transporter (ABC) A1, which is involved in the high-density lipoprotein-related reverse cholesterol transport pathway, we examined the effects of an HMG ...
Hitoshi, Ando, Shuichi, Tsuruoka, Hisashi, Yamamoto, Toshinari, Takamura, Shuichi, Kaneko, Akio, Fujimura   +5 more
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Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts

Biochemical and Biophysical Research Communications, 2003
The ATP-binding cassette transporter A1 (ABCA1) gene, a major regulator of high-density lipoprotein (HDL) metabolism, utilizes several transcriptional start sites. The pattern of transcripts among tissues and cells differed significantly. The longest (class 1) transcripts were abundant in adult brain and fetal tissues.
Jarkko, Huuskonen, Monika, Abedin, Meeta, Vishnu, Clive R, Pullinger, Sergio E, Baranzini, John P, Kane, Phoebe E, Fielding, Christopher J, Fielding   +7 more
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ATP-binding cassette transporter A1 and cholesterol trafficking

Current Opinion in Lipidology, 2002
Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway.
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The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients

International Journal of Obesity, 2009
ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux. We have investigated whether the expression of these transporters/receptor is altered in overweight and obese patients, and the potential association ...
M, Xu, H, Zhou, J, Wang, C, Li, Y, Yu
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ATP-binding cassette transporter A1: regulation of cholesterol efflux

Biochemical Society Transactions, 2004
The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells. Mutations in ABCA1 give rise to familial high-density lipoprotein (HDL) deficiency and Tangier disease, which is characterized by very low levels of HDL in plasma and cholesteryl ester accumulation in tonsils and other reticuloendothelial ...
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The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol Efflux

Biochemistry, 2007
ABCA1 is a key element of cholesterol efflux, but the mechanism of ABCA1-dependent cholesterol efflux is still unclear. Monoclonal antibodies against ABCA1 were used to map functional domains of ABCA1. Two antibodies were directed against a fragment of the first extracellular loop of ABCA1, and the third antibody was directed against a fragment of the ...
Nigora, Mukhamedova, Ying, Fu, Michael, Bukrinsky, Alan T, Remaley, Dmitri, Sviridov   +4 more
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The role of the ATP-binding cassette transporter A1 (ABCA1) in cholesterol metabolism

2021
The release of cellular cholesterol and phospholipid to apolipoproteins is thought to be the initial step in high density lipoprotein (HDL) formation. HDL is the lipid carrier of reverse cholesterol transport (RCT), the process by which cholesterol is mobilized from the periphery.
Anna E. Bortnick, George H. Rothblat
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Regulation of ATP-Binding Cassette Transporter A1 Transcription by Thyroid Hormone Receptor

Biochemistry, 2004
Transcriptional regulation of the ATP-binding cassette transporter (ABCA1) gene is complex. It involves multiple transcription start sites and the binding of several different transcription factors to the ABCA1 promoter region. Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and ...
Jarkko, Huuskonen, Meeta, Vishnu, Clive R, Pullinger, Phoebe E, Fielding, Christopher J, Fielding   +4 more
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ATP-binding cassette transporter A1, fatty acids, and cholesterol absorption

Current Opinion in Lipidology, 2003
A significant advance in our understanding of the reverse cholesterol transport pathway occurred in 1999 with the identification of defects in the ATP-binding cassette transporter A1 gene as the cause of Tangier disease. Since this discovery, an overwhelming number of experiments have been conducted to further define the function of this gene.
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Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages

Biochemical and Biophysical Research Communications, 2004
The ATP-binding-cassette transporter A1 (ABCA1) plays an essential role in cellular cholesterol efflux and helps prevent macrophages from becoming foam cells. The statins are widely used as cholesterol-lowering agents and have other anti-atherogenic actions.
Hirohito, Sone, Hitoshi, Shimano, Miao, Shu, Masanori, Nakakuki, Akimitsu, Takahashi, Masakazu, Sakai, Yuichiro, Sakamoto, Tomotaka, Yokoo, Ken, Matsuzaka, Hiroaki, Okazaki, Yoshimi, Nakagawa, Kaoruko Tada, Iida, Hiroaki, Suzuki, Hideo, Toyoshima, Seikoh, Horiuchi, Nobuhiro, Yamada   +15 more
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