Results 151 to 160 of about 11,680 (184)

The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a β2-syntrophin/utrophin complex

Biochemical and Biophysical Research Communications, 2002
Recent work identified ABCA1 as the major regulator of plasma HDL-cholesterol responsible for the removal of excess choline-phospholipids and cholesterol from peripheral cells and tissues. ABCA1 function may depend on the association with heteromeric proteins and to identify these candidates a human liver yeast two-hybrid library was screened with the ...
Christa, Buechler, Alfred, Boettcher, Salim Maa, Bared, Mario C O, Probst, Gerd, Schmitz   +4 more
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[Screening and identification of the upregulators of ATP-binding cassette transporter A1].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
ATP-binding cassette transporter A1 (ABCA1) promotes cholesterol and phospholipid efflux from cells to lipid-poor apolipoprotein A-I (apoA-I), and plays a key role in the initial steps of the whole process of reverse cholesterol transport (RCT). Upregulation of ABCA1 is beneficial for atherosclerosis (AS) prevention and/or therapy, which indicated that
Yan-Ni, Xu, Jie, Gao, Yang, Xu, Ji-Kai, Liu, Fang-Fang, Lai, Ye-Xiang, Wu, Bin, Hong, Shu-Yi, Si   +7 more
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ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism

Gastroenterology, 2001
Members of the family of ABC transporters are involved in different processes of sterol metabolism, and ABCA1 was recently identified as a key regulator of high-density lipoprotein (HDL) metabolism. Our aim was to further analyze the role of ABCA1 in cholesterol metabolism.ABCA1-deficient mice (ABCA1-/-) and wild-type mice were compared for different ...
W, Drobnik, B, Lindenthal, B, Lieser, M, Ritter, T, Christiansen Weber, G, Liebisch, U, Giesa, M, Igel, H, Borsukova, C, Büchler, W P, Fung-Leung, K, Von Bergmann, G, Schmitz   +12 more
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Glycaemic Influences on the ATP-Binding Cassette Transporter A1 (ABCA1)

2010
Increased glucose levels are associated with increased risk of vascular disease. The risk is elevated 2-4 fold in type 2 diabetes and there is a positive relationship between glucose (or HbA1c) levels and vascular disease in the general population. We tested the hypothesis that there is a glycaemia-mediated impairment of reverse cholesterol transport ...
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Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux

Cardiovascular & Hematological Disorders-Drug Targets, 2014
Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
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Genetic variation of the ATP-binding cassette transporter A1 and susceptibility to coronary heart disease

Molecular Genetics and Metabolism, 2011
ATP-binding cassette transporter A1 (ABCA1) is a member of a superfamily of membrane proteins that has attracted considerable attention as a candidate gene for coronary heart disease (CHD) based on its enzyme function as a key factor in regulating plasma HDL-C and apo A-I metabolism.
Zhihui, Jiang, Rujuan, Zhou, Caixia, Xu, Guangzhi, Feng, Yafeng, Zhou   +4 more
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Associations of ATP-Binding Cassette Transporter A1 and G1 With Insulin Secretion in Human Insulinomas

Pancreas, 2012
Adenosine triphosphate-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) are 2 important cholesterol transporters in human pancreatic β-cells. The aim of this study was to investigate their alteration in insulinomas and their potential associations with abnormal insulin secretion in these patients.Six patients with insulinoma and 6 healthy ...
Huali, Zhou, Chengjiang, Li, Jun, Li, Hongtian, Yao, Rong, Su, Wenpeng, Li, Mingzhi, Xu   +6 more
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Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons

Journal of Alzheimer's Disease, 2010
ATP-binding cassette transporter A1 (ABCA1) reduces amyloid-β burden in transgenic mouse models of Alzheimer's disease (AD). Associations between ABCA1 polymorphisms and AD risk are also established. Little is known regarding the regulation of ABCA1 expression in the brain and how this may be affected by AD.
Garner, Brett, McCann, H, Halliday, Glenda, Barnham, K J, Elliott, David, Kim, Woojin Scott, Agholme, Lotta, Kgedal, Katarina, Bhatia, Surabhi   +8 more
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Ins and outs of the ATP-binding cassette transporter A1

Current Opinion in Lipidology, 2016
Dmitri, Sviridov, Yury I, Miller
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The ATP binding cassette transporter A1 gene : expression and role in hypoalphalipoproteinemia

2002
The present study was undertaken primarily to determine the prevalence of ABCA1 gene defects in a selected population with a HDL-C < 5 th percentile. The results showed that 30% of the selected patients had a lipid efflux defect and 16% (10/64) of those patients had a mutation in the ABCA1 gene.
openaire   +1 more source