Results 161 to 170 of about 156,745 (364)

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

open access: yesiMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu   +8 more
wiley   +1 more source

Investigation on Klebsiella pneumoniae in the field of extracellular vesicles

open access: yesInterdisciplinary Medicine, EarlyView.
The role of extracellular vesicles in the pathogenicity and antibiotic resistance, as well as treatment and prevention of Klebsiella pneumoniae. Abstract Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital‐acquired pneumonia.
Junwei Wu   +10 more
wiley   +1 more source

The insertion of Neomycin cassette impairs maternal and social behaviors in Arc/Arg3.1 knock-out mice [PDF]

open access: yesarXiv
The Neomycin resistance cassette (Neo+) is commonly inserted in the genome of mice to generate knock-out (KO) models. The effect of gene deletion on social behaviors in mice is controversial between studies using different Neo+ and Neo-mouse lines, particularly Arc/Arg3.1 KO lines.
arxiv  

Exploring the Role of T‐Cell Metabolism in Modulating Immunotherapy Efficacy for Non‐Small Cell Lung Cancer Based on Clustering

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
We conducted a comprehensive investigation of the metabolic profiles of infiltrating T cells in NSCLC tumors and found metabolic heterogeneity in three T‐cell subtypes, which are associated with the prognosis of ICB therapy. We defined these metabolic clusters as response‐dependent (R) clusters and non‐response‐dependent (NR) clusters, and elucidated ...
Hongzhe Guo   +7 more
wiley   +1 more source

ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis

open access: yesInternational Journal of Infectious Diseases
Leishmania spp. are intracellular protozoan parasites causative of visceral and cutaneous leishmaniasis. Recognized as a neglected tropical disease affecting millions of people around the world, this affliction represents a major public health problem ...
Marina B.R. de Santana   +2 more
doaj  

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats

open access: yesLipids, EarlyView.
Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley   +1 more source

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